HitPredict

Interactor 1: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Interactor 2: TF65 (Q04206)
Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
Gene: RELA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.55	0.613

The method score is based on:

Property	Details
Experiments	23839035, 21988832
Identification Methods	affinity chromatography technology, pull down, two hybrid, two hybrid array
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol and 8 others more... GO:0008284 - positive regulation of cell population proliferation GO:0009410 - response to xenobiotic stimulus GO:0010628 - positive regulation of gene expression GO:0019899 - enzyme binding GO:0031625 - ubiquitin protein ligase binding GO:0043066 - negative regulation of apoptotic process GO:0045892 - negative regulation of DNA-templated transcription GO:0070301 - cellular response to hydrogen peroxide
Homologous interactions	0

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Last updated: 15 Jul 2024