HitPredict

Interactor 1: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Interactor 2: ARF (Q8N726)
Tumor suppressor ARF (Alternative reading frame) (ARF) (Cyclin-dependent kinase inhibitor 2A) (p14ARF)
Gene: CDKN2A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.737

The method score is based on:

Property	Details
Experiments	11223036, 9529249, 9724636, 17909018, 18583933, 20713054, 19166854
Identification Methods	coimmunoprecipitation, experimental interaction detection, two hybrid, anti bait coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000209 - protein polyubiquitination GO:0002039 - p53 binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus and 10 others more... GO:0005829 - cytosol GO:0010628 - positive regulation of gene expression GO:0016925 - protein sumoylation GO:0019789 - SUMO transferase activity GO:0031648 - protein destabilization GO:0032991 - protein-containing complex GO:0034504 - protein localization to nucleus GO:0051726 - regulation of cell cycle GO:0097718 - disordered domain specific binding GO:1990000 - amyloid fibril formation
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	491
Hs

1	132

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024