HitPredict

Interactor 1: NMDE2 (Q01097)
Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B)
Gene: Grin2b

Interactor 2: ACTN2 (Q9JI91)
Alpha-actinin-2 (Alpha-actinin skeletal muscle isoform 2) (F-actin cross-linking protein)
Gene: ACTN2

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	10862698, 16710293
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0030018 - Z disc GO:0098839 - postsynaptic density membrane GO:0098978 - glutamatergic synapse GO:0099092 - postsynaptic density, intracellular component
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1482 Mm			1 894
+	Hs
		725650 NMDE2_HUMAN (1-1482): 0: 1855: 98.38		ACTN2_HUMAN (1-894): 0: 666: 99.22
+	Rn
		723638 NMDZ1_RAT (14-940): 0: 683: 23.52		ACTN1_RAT (10-894): 0: 677: 80.00
+	Mm
		723613 NMDZ1_MOUSE (14-940): 0: 681: 23.41		ACTN2_MOUSE (1-894): 0: 667: 100.00
+	Hs
		725646 NMDZ1_HUMAN (14-940): 0: 678: 23.52		ACTN2_HUMAN (1-894): 0: 666: 99.22
+	Hs
		211568 NMDZ1_HUMAN (14-940): 0: 678: 23.52		ACTN4_HUMAN (18-894): 0: 635: 78.23
+	Rn
		585223 GRIA4_RAT (17-852): 0: 652: 21.12		ACTN4_RAT (18-894): 0: 632: 77.78
+	Mm
		723587 NMDZ1_MOUSE (14-940): 0: 681: 23.41		SPTB2_MOUSE (228-770): 9.31e-15: 81.2: 12.48
+	Hs
		786728 GRIA2_HUMAN (8-871): 0: 677: 21.16		SPTB2_HUMAN (228-770): 8.77e-15: 81.2: 12.48
+	Rn
		585221 GRIA4_RAT (17-852): 0: 652: 21.12		SPTN2_RAT (249-770): 2.26e-13: 76.6: 12.21