Protein: SET3
SET domain-containing protein 3

Gene: SET3
Organism: Saccharomyces cerevisiae S288C
Interactions: 159
UniProt ID: P36124

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0006355 - regulation of DNA-templated transcription
GO:0006974 - DNA damage response
GO:0008270 - zinc ion binding
GO:0009267 - cellular response to starvation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

781735

SIF2
SIR4-interacting protein SIF2

8

20

Small-scale

0.965

High

781781

H3
Histone H3

3

20

Small-scale

0.830

High

382034

H4
Histone H4

2

12

Small-scale

0.759

High

672762

SNT1
Probable DNA-binding protein SNT1

7

12

Small-scale

0.742

High

781750

HOS4
Protein HOS4

7

3

Small-scale

0.742

High

781769

HOS2
Probable histone deacetylase HOS2

6

20

Small-scale

0.727

High

781776

HST1
NAD-dependent protein deacetylase HST1

5

11

Small-scale

0.706

High

575925

CYPH
Peptidyl-prolyl cis-trans isomerase

5

6

Small-scale

0.699

High

567719

MSI1
Histone-binding protein MSI1

1

20

High-throughput

0.691

High

781731

GBLP
Small ribosomal subunit protein RACK1

1

20

High-throughput

0.618

High

781744

SWD1
COMPASS component SWD1

1

20

Small-scale

0.618

High

781804

IMB1
Importin subunit beta-1

2

2

High-throughput

0.601

High

381491

H2B2
Histone H2B.2

1

20

High-throughput

0.575

High

419701

H2A2
Histone H2A.2

1

11

High-throughput

0.575

High

781729

SET3
SET domain-containing protein 3

1

18

High-throughput

0.575

High

781733

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

20

High-throughput

0.575

High

781823

CMR1
DNA damage-binding protein CMR1

1

20

High-throughput

0.575

High

781824

H2AZ
Histone H2A.Z

1

11

High-throughput

0.575

High

781764

ZDS1
Protein ZDS1

2

5

High-throughput

0.567

High

523628

HSP71
Heat shock protein SSA1

2

4

High-throughput

0.552

High

544490

SSB1
Ribosome-associated molecular chaperone SSB1

2

8

High-throughput

0.552

High

781789

IMA1
Importin subunit alpha

2

5

High-throughput

0.552

High

721851

XPO1
Exportin-1

1

5

High-throughput

0.536

High

739600

SPT16
FACT complex subunit SPT16

2

2

High-throughput

0.521

High

781751

LST8
Target of rapamycin complex subunit LST8

1

20

High-throughput

0.514

High

646372

RAD53
Serine/threonine-protein kinase RAD53

1

2

Small-scale

0.501

High

763054

RRP1
Ribosomal RNA-processing protein 1

1

0

High-throughput

0.493

High

706804

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

709356

HRR25
Casein kinase I homolog HRR25

1

1

Small-scale

0.479

High

734936

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

763873

SPT10
Protein SPT10

1

1

High-throughput

0.479

High

781732

ANM1
Protein arginine N-methyltransferase 1

1

4

High-throughput

0.479

High

781743

UME6
Transcriptional regulatory protein UME6

1

1

High-throughput

0.479

High

781798

LRS4
Monopolin complex subunit LRS4

1

0

Small-scale

0.458

High

781809

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.458

High

781816

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

440840

KIN28
Serine/threonine-protein kinase KIN28

1

5

High-throughput

0.445

High

444765

SIR2
NAD-dependent histone deacetylase SIR2

1

11

High-throughput

0.445

High

449453

SPT3
SAGA complex subunit SPT3

1

1

High-throughput

0.445

High

561465

TBP
TATA-box-binding protein

1

1

High-throughput

0.445

High

614819

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

9

High-throughput

0.445

High

622929

CSK22
Casein kinase II subunit alpha'

1

10

High-throughput

0.445

High

661161

SPT6
Transcription elongation factor SPT6

1

4

High-throughput

0.445

High

664431

MCM3
DNA replication licensing factor MCM3

1

5

High-throughput

0.445

High

670581

SIS1
Protein SIS1

1

3

High-throughput

0.445

High

675909

MAS5
Mitochondrial protein import protein MAS5

1

2

High-throughput

0.445

High

678315

RSC6
Chromatin structure-remodeling complex protein RSC6

1

2

High-throughput

0.445

High

682913

MSH2
DNA mismatch repair protein MSH2

1

1

High-throughput

0.445

High

694527

SPT5
Transcription elongation factor SPT5

1

3

High-throughput

0.445

High

708717

TF3B
Transcription factor IIIB 70 kDa subunit

1

3

High-throughput

0.445

High

712971

MCM2
DNA replication licensing factor MCM2

1

7

High-throughput

0.445

High

713261

MCM5
Minichromosome maintenance protein 5

1

5

High-throughput

0.445

High

734415

BTAF1
TATA-binding protein-associated factor MOT1

1

20

High-throughput

0.445

High

737629

HIR1
Protein HIR1

1

20

High-throughput

0.445

High

737667

HIR2
Protein HIR2

1

15

High-throughput

0.445

High

743080

STH1
Nuclear protein STH1/NPS1

1

14

High-throughput

0.445

High

744285

CHD1
Chromo domain-containing protein 1

1

12

High-throughput

0.445

High

750062

MRT4
Ribosome assembly factor MRT4

1

3

High-throughput

0.445

High

751894

TFC4
Transcription factor tau 131 kDa subunit

1

7

High-throughput

0.445

High

757757

SAS3
Histone acetyltransferase SAS3

1

10

High-throughput

0.445

High

781734

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

1

16

High-throughput

0.445

High

781738

RSC30
Chromatin structure-remodeling complex protein RSC30

1

1

High-throughput

0.445

High

781739

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit TRA1

1

5

High-throughput

0.445

High

781741

KOG1
Target of rapamycin complex 1 subunit KOG1

1

17

High-throughput

0.445

High

781742

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

2

High-throughput

0.445

High

781747

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.445

High

781756

RSC8
Chromatin structure-remodeling complex protein RSC8

1

8

High-throughput

0.445

High

781757

CSK2B
Casein kinase II subunit beta

1

4

High-throughput

0.445

High

781758

SUM1
Suppressor of mar1-1 protein

1

1

High-throughput

0.445

High

781767

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

1

1

High-throughput

0.445

High

781768

MCM6
DNA replication licensing factor MCM6

1

6

High-throughput

0.445

High

781771

INO80
Chromatin-remodeling ATPase INO80

1

17

High-throughput

0.445

High

781773

ITC1
Imitation switch two complex protein 1

1

1

High-throughput

0.445

High

781777

ARP5
Actin-related protein 5

1

3

High-throughput

0.445

High

781778

ORC1
Origin recognition complex subunit 1

1

2

High-throughput

0.445

High

781779

ORC4
Origin recognition complex subunit 4

1

2

High-throughput

0.445

High

781780

ACT
Actin

1

2

High-throughput

0.445

High

781782

ARP4
Actin-related protein 4

1

5

High-throughput

0.445

High

781783

RAD25
General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2

1

1

High-throughput

0.445

High

781784

CDC14
Tyrosine-protein phosphatase CDC14

1

7

High-throughput

0.445

High

781787

ADA2
SAGA complex subunit ADA2

1

8

High-throughput

0.445

High

781791

HOS3
Histone deacetylase HOS3

1

20

High-throughput

0.445

High

781794

GCN5
Histone acetyltransferase GCN5

1

20

High-throughput

0.445

High

781795

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

1

7

High-throughput

0.445

High

781796

MSH6
DNA mismatch repair protein MSH6

1

1

High-throughput

0.445

High

781797

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.445

High

781799

DPB4
DNA polymerase epsilon subunit D

1

2

High-throughput

0.445

High

781801

TRI1
Protein TRI1

1

2

High-throughput

0.445

High

781802

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

1

High-throughput

0.445

High

781803

ARP9
Actin-like protein ARP9

1

2

High-throughput

0.445

High

781805

SFH1
Chromatin structure-remodeling complex subunit SFH1

1

4

High-throughput

0.445

High

781806

FKBP4
FK506-binding protein 4

1

2

High-throughput

0.445

High

781810

RSC3
Chromatin structure-remodeling complex protein RSC3

1

1

High-throughput

0.445

High

781811

BRE1
E3 ubiquitin-protein ligase BRE1

1

8

High-throughput

0.445

High

781814

ISW2
ISWI chromatin-remodeling complex ATPase ISW2

1

18

High-throughput

0.445

High

781818

ARP8
Actin-like protein ARP8

1

3

High-throughput

0.445

High

781819

ARP7
Actin-related protein 7

1

4

High-throughput

0.445

High

781821

EAF3
Chromatin modification-related protein EAF3

1

6

High-throughput

0.445

High

781822

RUVB2
RuvB-like protein 2

1

2

High-throughput

0.445

High

149697

RS9A
Small ribosomal subunit protein uS4A

1

4

High-throughput

0.437

High

383636

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.437

High

410060

RL25
Large ribosomal subunit protein uL23

1

5

High-throughput

0.437

High

433573

RL26A
Large ribosomal subunit protein uL24A

1

3

High-throughput

0.437

High

435896

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.437

High

454995

RS19A
Small ribosomal subunit protein eS19A

1

3

High-throughput

0.437

High

512944

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

514578

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.437

High

674550

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.437

High

747295

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

753301

RS3A1
Small ribosomal subunit protein eS1A

1

3

High-throughput

0.437

High

781737

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.437

High

781813

RS10A
Small ribosomal subunit protein eS10A

1

7

High-throughput

0.437

High

149209

FOB1
DNA replication fork-blocking protein FOB1

1

0

High-throughput

0.426

High

397494

REP1
Partitioning protein REP1

1

0

High-throughput

0.426

High

550047

RAP1
DNA-binding protein RAP1

1

0

High-throughput

0.426

High

553530

PDR1
Transcription factor PDR1

1

0

High-throughput

0.426

High

743184

PP12
Serine/threonine-protein phosphatase PP1-2

1

0

High-throughput

0.426

High

745577

RSC7
Chromatin structure-remodeling complex subunit RSC7

1

0

High-throughput

0.426

High

781740

ORC6
Origin recognition complex subunit 6

1

0

High-throughput

0.426

High

781746

VHR2
Transcription factor VHR2

1

0

High-throughput

0.426

High

781748

IES2
Ino eighty subunit 2

1

0

High-throughput

0.426

High

781749

ATAD2
ATPase histone chaperone YTA7

1

0

High-throughput

0.426

High

781752

MOB2
CBK1 kinase activator protein MOB2

1

0

High-throughput

0.426

High

781753

EPL1
Enhancer of polycomb-like protein 1

1

0

High-throughput

0.426

High

781754

IES1
Ino eighty subunit 1

1

0

High-throughput

0.426

High

781755

IOC3
ISWI one complex protein 3

1

0

High-throughput

0.426

High

781759

TFC5
Transcription factor TFIIIB component B''

1

0

High-throughput

0.426

High

781760

RRP41
Exosome complex component SKI6

1

0

High-throughput

0.426

High

781763

TAF4
Transcription initiation factor TFIID subunit 4

1

0

High-throughput

0.426

High

781765

ORC5
Origin recognition complex subunit 5

1

0

High-throughput

0.426

High

781766

SPT20
SAGA complex subunit SPT20

1

0

High-throughput

0.426

High

781770

MED5
Mediator of RNA polymerase II transcription subunit 5

1

0

High-throughput

0.426

High

781774

RT102
Regulator of Ty1 transposition protein 102

1

0

High-throughput

0.426

High

781775

H1
Histone H1

1

0

High-throughput

0.426

High

781788

TBF1
Protein TBF1

1

0

High-throughput

0.426

High

781792

DIG1
Down-regulator of invasive growth 1

1

0

High-throughput

0.426

High

781793

RSC9
Chromatin structure-remodeling complex subunit RSC9

1

0

High-throughput

0.426

High

781807

TOS4
Protein TOS4

1

0

High-throughput

0.426

High

781812

RSC58
Chromatin structure-remodeling complex protein RSC58

1

0

High-throughput

0.426

High

781815

IOC2
ISWI one complex protein 2

1

0

High-throughput

0.426

High

781817

IES3
Ino eighty subunit 3

1

0

High-throughput

0.426

High

781820

TFC7
Transcription factor tau 55 kDa subunit

1

0

High-throughput

0.426

High

394452

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.407

High

781006

VPS24
Vacuolar protein-sorting-associated protein 24

1

2

High-throughput

0.407

High

781315

DID4
DOA4-independent degradation protein 4

1

2

High-throughput

0.407

High

781745

HSP7E
Heat shock protein SSC3, mitochondrial

1

3

High-throughput

0.407

High

781761

NET1
Nucleolar protein NET1

1

2

High-throughput

0.407

High

781785

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

20

High-throughput

0.407

High

781786

TOF2
Topoisomerase 1-associated factor 2

1

2

High-throughput

0.407

High

781790

TFB2
General transcription and DNA repair factor IIH subunit TFB2

1

1

High-throughput

0.407

High

781800

POB3
FACT complex subunit POB3

1

5

High-throughput

0.407

High

781808

RSC2
Chromatin structure-remodeling complex subunit RSC2

1

20

High-throughput

0.407

High

689385

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

781736

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.249

Low

781762

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

781772

YGO0
Uncharacterized membrane protein YGL140C

1

0

High-throughput

0.249

Low

361480

SODM
Superoxide dismutase [Mn], mitochondrial

1

0

High-throughput

0.232

Low

781730

STT4
Phosphatidylinositol 4-kinase STT4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025