HitPredict

Interactor 1: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Interactor 2: USF2 (Q15853)
Upstream stimulatory factor 2 (Class B basic helix-loop-helix protein 12) (bHLHb12) (FOS-interacting protein) (FIP) (Major late transcription factor 2) (Upstream transcription factor 2)
Gene: USF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	10434034
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2414 Hs			1 346
+	Hs
		607813 EP300_HUMAN (1-2414): 0: 1113: 100.00		USF1_HUMAN (22-340): 2.39e-74: 233: 48.81
+	Mm
		70922 EP300_MOUSE (1-2414): 0: 1090: 93.01		USF1_MOUSE (22-340): 8.55e-73: 229: 50.78
+	Hs
		999115 EP300_HUMAN (1-2414): 0: 1113: 100.00		MLXPL_HUMAN (88-346): 3.5e-38: 146: 17.79
+	Hs
		252921 EP300_HUMAN (1-2414): 0: 1113: 100.00		MITF_HUMAN (102-338): 1.95e-31: 125: 18.21
+	Hs
		346630 EP300_HUMAN (1-2414): 0: 1113: 100.00		MYC_HUMAN (115-326): 5.58e-30: 120: 19.54
+	Hs
		738960 EP300_HUMAN (1-2414): 0: 1113: 100.00		SRBP1_HUMAN (101-345): 3.08e-27: 114: 17.11
+	Hs
		998613 EP300_HUMAN (1-2414): 0: 1113: 100.00		SRBP2_HUMAN (47-315): 1.31e-25: 110: 20.73
+	Hs
		379333 EP300_HUMAN (1-2414): 0: 1113: 100.00		MYCN_HUMAN (136-324): 9.83e-22: 97.5: 15.87
+	Hs
		898111 EP300_HUMAN (1-2414): 0: 1113: 100.00		MAX_HUMAN (223-335): 3.67e-22: 93.1: 31.86
+	Hs
		348397 NCOA3_HUMAN (1849-2386): 7.64e-52: 204: 21.89		MYC_HUMAN (115-326): 5.58e-30: 120: 19.54
+	Hs
		347993 BAZ1A_HUMAN (889-1176): 3.58e-51: 202: 21.31		MYC_HUMAN (115-326): 5.58e-30: 120: 19.54
+	Hs
		348006 BRWD1_HUMAN (1007-1168): 2.52e-44: 180: 32.93		MYC_HUMAN (115-326): 5.58e-30: 120: 19.54
+	Hs
		348246 TRI33_HUMAN (604-1201): 1.37e-44: 180: 14.50		MYC_HUMAN (115-326): 5.58e-30: 120: 19.54
+	Hs
		898207 BAZ1A_HUMAN (889-1176): 3.58e-51: 202: 21.31		MAX_HUMAN (223-335): 3.67e-22: 93.1: 31.86
+	Mm
		348442 BRD8_MOUSE (442-1175): 6.73e-37: 154: 14.71		MYC_MOUSE (115-326): 7.07e-31: 123: 18.61
+	Hs
		345960 BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20		MYC_HUMAN (115-326): 5.58e-30: 120: 19.54
+	Hs
		346831 BRD3_HUMAN (1055-1159): 9.06e-30: 130: 30.48		MYC_HUMAN (115-326): 5.58e-30: 120: 19.54
+	Mm
		659352 BRD8_MOUSE (442-1175): 6.73e-37: 154: 14.71		MAX_MOUSE (223-335): 2.05e-22: 93.9: 31.86
+	Hs
		347855 BRD8_HUMAN (965-1183): 9.91e-16: 86: 19.18		MYC_HUMAN (115-326): 5.58e-30: 120: 19.54
+	Hs
		898192 BRD8_HUMAN (965-1183): 9.91e-16: 86: 19.18		MAX_HUMAN (223-335): 3.67e-22: 93.1: 31.86