HitPredict

Interactor 1: NOTC1 (Q01705)
Neurogenic locus notch homolog protein 1 (Notch 1) (Motch A) (mT14) (p300) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
Gene: Notch1

Interactor 2: DLL1 (Q61483)
Delta-like protein 1 (Drosophila Delta homolog 1) (Delta1) [Cleaved into: Dll1-soluble form (Dll1-EC) (Shed form); Dll1-derived cell-associated form (Dll1-TMIC) (Membrane-associated fragment); Dll1-intracellular form (Dll1-IC)]
Gene: DLL1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.41 1.00 0.647

The method score is based on:

Property Details
Experiments 21985982
Identification Methods pull down
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains EGF~EGF, DSL~EGF_CA, EGF~EGF_CA, EGF_CA~MNNL
Common GO terms GO:0001701 - in utero embryonic development
GO:0001947 - heart looping
GO:0002085 - inhibition of neuroepithelial cell differentiation
GO:0005112 - Notch binding
GO:0005509 - calcium ion binding
and 23 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 2531
Mm

1 722
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+ Mm
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024