Protein: RABX5
Rab5 GDP/GTP exchange factor (RAP1) (Rabaptin-5-associated exchange factor for Rab5) (Rabex-5)

Gene: RABX5, RABGEF1
Organism: Homo sapiens
Interactions: 170
UniProt ID: Q9UJ41

Gene Ontology (top 5):
GO:0002686 - negative regulation of leukocyte migration
GO:0003677 - DNA binding
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005730 - nucleolus
GO:0005769 - early endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

508796

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

13

7

Small-scale

0.977

High

1144893

RABE1
Rab GTPase-binding effector protein 1

11

6

Small-scale

0.977

High

1460534

RAB21
Ras-related protein Rab-21

4

20

Small-scale

0.906

High

631545

RAB5A
Ras-related protein Rab-5A

4

20

Small-scale

0.878

High

1434693

RABE2
Rab GTPase-binding effector protein 2

3

6

High-throughput

0.855

High

1460530

RABX5
Rab5 GDP/GTP exchange factor

3

7

Small-scale

0.850

High

631012

RAB4A
Ras-related protein Rab-4A

2

10

High-throughput

0.789

High

931615

RD23A
UV excision repair protein RAD23 homolog A

2

4

High-throughput

0.783

High

987495

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

2

4

High-throughput

0.783

High

976643

RB11A
Ras-related protein Rab-11A

2

3

High-throughput

0.754

High

730335

1433B
14-3-3 protein beta/alpha

5

20

High-throughput

0.712

High

966990

1433G
14-3-3 protein gamma

5

20

High-throughput

0.712

High

507411

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

7

Small-scale

0.692

High

1419257

TRI54
Tripartite motif-containing protein 54

3

12

High-throughput

0.675

High

990844

1433Z
14-3-3 protein zeta/delta

3

20

High-throughput

0.662

High

1090969

TRAF2
TNF receptor-associated factor 2

3

4

High-throughput

0.662

High

1107502

BIRC2
Baculoviral IAP repeat-containing protein 2

3

1

High-throughput

0.662

High

1291004

TAXB1
Tax1-binding protein 1

3

3

High-throughput

0.662

High

1389415

RNF31
E3 ubiquitin-protein ligase RNF31

3

1

High-throughput

0.662

High

1418834

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

3

1

High-throughput

0.662

High

1429998

SHRPN
Sharpin

3

1

High-throughput

0.662

High

1350741

CCHCR
Coiled-coil alpha-helical rod protein 1

3

2

High-throughput

0.653

High

1049886

1433F
14-3-3 protein eta

3

20

High-throughput

0.650

High

375001

RASH
GTPase HRas

1

17

Small-scale

0.647

High

906817

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

1

Small-scale

0.647

High

957231

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

1

Small-scale

0.647

High

1460536

BL1S6
Biogenesis of lysosome-related organelles complex 1 subunit 6

3

0

High-throughput

0.646

High

333412

SNAPN
SNARE-associated protein Snapin

3

0

High-throughput

0.639

High

1135399

SLMAP
Sarcolemmal membrane-associated protein

4

3

High-throughput

0.638

High

171780

GAK
Cyclin-G-associated kinase

2

1

High-throughput

0.628

High

1048277

HGFA
Hepatocyte growth factor activator serine protease

2

2

High-throughput

0.628

High

1129905

EPN4
Clathrin interactor 1

2

1

High-throughput

0.628

High

1153229

HERC1
Probable E3 ubiquitin-protein ligase HERC1

2

3

High-throughput

0.628

High

1391428

OTUD5
OTU domain-containing protein 5

2

1

High-throughput

0.628

High

1432568

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

2

3

High-throughput

0.628

High

1460532

GGA1
ADP-ribosylation factor-binding protein GGA1

2

2

Small-scale

0.625

High

363995

EGFR
Epidermal growth factor receptor

2

10

Small-scale

0.621

High

1460538

RNF11
RING finger protein 11

2

2

High-throughput

0.620

High

376072

RASK
GTPase KRas

1

18

High-throughput

0.618

High

901093

RAB5C
Ras-related protein Rab-5C

1

20

High-throughput

0.618

High

958046

RAB14
Ras-related protein Rab-14

1

10

High-throughput

0.618

High

1460535

RB22A
Ras-related protein Rab-22A

1

20

Small-scale

0.618

High

1213049

CC183
Coiled-coil domain-containing protein 183

3

3

High-throughput

0.609

High

1295621

RASL3
RAS protein activator like-3

2

2

High-throughput

0.606

High

1322323

SPART
Spartin

2

2

High-throughput

0.606

High

1388880

HOOK2
Protein Hook homolog 2

2

4

High-throughput

0.606

High

1413284

TCHP
Trichoplein keratin filament-binding protein

2

6

High-throughput

0.606

High

1452518

ABI2
Abl interactor 2

2

7

High-throughput

0.606

High

1460531

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

12

High-throughput

0.606

High

1390829

CPNE2
Copine-2

3

1

High-throughput

0.604

High

622704

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

0

High-throughput

0.602

High

1311128

UBR1
E3 ubiquitin-protein ligase UBR1

2

0

High-throughput

0.602

High

1450284

EXOC1
Exocyst complex component 1

2

0

High-throughput

0.602

High

1459040

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

2

0

High-throughput

0.602

High

1385478

Q96C32
UBC protein

1

7

High-throughput

0.594

High

517299

ZTRF1
Zinc finger TRAF-type-containing protein 1

3

0

High-throughput

0.585

High

1110757

DCTN2
Dynactin subunit 2

2

0

High-throughput

0.580

High

1158595

CDC37
Hsp90 co-chaperone Cdc37

2

0

High-throughput

0.580

High

1384150

ARRD3
Arrestin domain-containing protein 3

2

0

High-throughput

0.580

High

1386972

GASP2
G-protein coupled receptor-associated sorting protein 2

2

0

High-throughput

0.580

High

1439079

CPNE5
Copine-5

2

1

High-throughput

0.574

High

1407209

THIOM
Thioredoxin, mitochondrial

1

4

High-throughput

0.573

High

1420533

TRI15
E3 ubiquitin-protein ligase TRIM15

1

7

High-throughput

0.573

High

1291747

SESD1
SEC14 domain and spectrin repeat-containing protein 1

2

3

High-throughput

0.553

High

1329231

ANR29
Ankyrin repeat domain-containing protein 29

2

2

High-throughput

0.553

High

1460540

EMIL1
EMILIN-1

2

1

High-throughput

0.553

High

1198868

ZC21C
Zinc finger C2HC domain-containing protein 1C

1

0

High-throughput

0.549

High

1390994

THOC1
THO complex subunit 1

1

0

High-throughput

0.549

High

1420873

CIPC
CLOCK-interacting pacemaker

1

0

High-throughput

0.549

High

156368

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

1

1

High-throughput

0.536

High

92356

D3DUQ6
TEA domain family member 4 isoform 1

1

1

High-throughput

0.515

High

1123862

DCTN1
Dynactin subunit 1

1

3

High-throughput

0.515

High

252795

AP180
Clathrin coat assembly protein AP180

1

0

High-throughput

0.513

High

1041358

CAV1
Caveolin-1

1

0

High-throughput

0.513

High

1460541

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.513

High

1291805

MON1A
Vacuolar fusion protein MON1 homolog A

1

2

Small-scale

0.501

High

1432995

DNJC5
DnaJ homolog subfamily C member 5

1

3

High-throughput

0.501

High

791817

SYUA
Alpha-synuclein

1

0

High-throughput

0.493

High

137516

BT3A1
Butyrophilin subfamily 3 member A1

1

5

High-throughput

0.489

High

388022

FIBG
Fibrinogen gamma chain

1

1

High-throughput

0.489

High

682648

S100P
Protein S100-P

1

2

High-throughput

0.489

High

1399073

TMM74
Transmembrane protein 74

1

1

High-throughput

0.489

High

128488

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

1

High-throughput

0.479

High

132774

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

4

High-throughput

0.479

High

192969

CLOCK
Circadian locomoter output cycles protein kaput

1

4

High-throughput

0.479

High

397172

ESR1
Estrogen receptor

1

3

Small-scale

0.479

High

412772

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.479

High

462019

HS90A
Heat shock protein HSP 90-alpha

1

5

High-throughput

0.479

High

468892

HS90B
Heat shock protein HSP 90-beta

1

5

High-throughput

0.479

High

691520

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

703738

MK01
Mitogen-activated protein kinase 1

1

4

Small-scale

0.479

High

730944

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

831609

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

942946

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

5

High-throughput

0.479

High

959677

MAX
Protein max

1

3

High-throughput

0.479

High

1111497

IQGA2
Ras GTPase-activating-like protein IQGAP2

1

2

High-throughput

0.479

High

1122459

GIT2
ARF GTPase-activating protein GIT2

1

1

High-throughput

0.479

High

1142007

EEA1
Early endosome antigen 1

1

4

Small-scale

0.479

High

1201171

CCD93
Coiled-coil domain-containing protein 93

1

1

High-throughput

0.479

High

1212876

UBR4
E3 ubiquitin-protein ligase UBR4

1

2

High-throughput

0.479

High

1243065

PKN3
Serine/threonine-protein kinase N3

1

1

High-throughput

0.479

High

1256006

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.479

High

1276362

ATG9A
Autophagy-related protein 9A

1

1

High-throughput

0.479

High

1294587

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

3

High-throughput

0.479

High

1348357

GOGA5
Golgin subfamily A member 5

1

2

High-throughput

0.479

High

1384470

PF21A
PHD finger protein 21A

1

1

High-throughput

0.479

High

1403145

CRBN
Protein cereblon

1

1

Small-scale

0.479

High

1419607

NUF2
Kinetochore protein Nuf2

1

6

High-throughput

0.479

High

1445908

HM20A
High mobility group protein 20A

1

1

High-throughput

0.479

High

69416

WASH1
WASH complex subunit 1

1

0

High-throughput

0.460

High

503676

TFPT
TCF3 fusion partner

1

0

High-throughput

0.458

High

731943

L1CAM
Neural cell adhesion molecule L1

1

0

Small-scale

0.458

High

844070

HD
Huntingtin

1

0

High-throughput

0.458

High

1196338

GRAP1
GRIP1-associated protein 1

1

0

High-throughput

0.458

High

1217294

VPS53
Vacuolar protein sorting-associated protein 53 homolog

1

0

High-throughput

0.458

High

1239972

CAVN1
Caveolae-associated protein 1

1

0

High-throughput

0.458

High

1278459

HAUS6
HAUS augmin-like complex subunit 6

1

0

High-throughput

0.458

High

1389087

THA11
THAP domain-containing protein 11

1

0

High-throughput

0.458

High

1394943

VPS50
Syndetin

1

0

High-throughput

0.458

High

1432911

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

0

Small-scale

0.458

High

1271339

MON1B
Vacuolar fusion protein MON1 homolog B

1

2

Small-scale

0.457

High

208584

PJA2
E3 ubiquitin-protein ligase Praja-2

1

2

High-throughput

0.445

High

326084

UBR5
E3 ubiquitin-protein ligase UBR5

1

3

High-throughput

0.445

High

861830

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

2

High-throughput

0.445

High

922526

CLH2
Clathrin heavy chain 2

1

3

High-throughput

0.445

High

1026270

CLH1
Clathrin heavy chain 1

1

3

High-throughput

0.445

High

1199052

KLH12
Kelch-like protein 12

1

2

High-throughput

0.445

High

1199742

KLH22
Kelch-like protein 22

1

2

High-throughput

0.445

High

1256911

TM1L2
TOM1-like protein 2

1

2

High-throughput

0.445

High

1273823

NIPA1
Magnesium transporter NIPA1

1

1

High-throughput

0.445

High

1400048

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

2

High-throughput

0.445

High

1429767

BTBD1
BTB/POZ domain-containing protein 1

1

3

High-throughput

0.445

High

1450913

RNF12
E3 ubiquitin-protein ligase RLIM

1

2

High-throughput

0.445

High

1460539

RN115
E3 ubiquitin-protein ligase RNF115

1

1

High-throughput

0.445

High

1120890

DGCR6
Protein DGCR6

1

1

High-throughput

0.439

High

1150224

TEAD4
Transcriptional enhancer factor TEF-3

1

1

High-throughput

0.439

High

1237932

PHLB3
Pleckstrin homology-like domain family B member 3

1

2

High-throughput

0.437

High

483250

CLCA
Clathrin light chain A

1

0

High-throughput

0.426

High

1381249

WBP2
WW domain-binding protein 2

1

0

High-throughput

0.426

High

1402265

WRIP1
ATPase WRNIP1

1

0

High-throughput

0.426

High

1429876

TOLIP
Toll-interacting protein

1

0

High-throughput

0.426

High

1447788

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.426

High

1460537

MYO6
Unconventional myosin-VI

1

0

High-throughput

0.426

High

1460542

X5DP20
DiGeorge syndrome critical region 6 isoform D

1

1

High-throughput

0.417

High

1256364

AN13D
Ankyrin repeat domain-containing protein 13D

1

2

High-throughput

0.407

High

1338003

ZNT7
Zinc transporter 7

1

1

High-throughput

0.407

High

1139158

DAZP2
DAZ-associated protein 2

3

0

High-throughput

0.352

High

217222

MS18B
Protein Mis18-beta

3

0

High-throughput

0.340

High

1314621

IHO1
Interactor of HORMAD1 protein 1

2

0

High-throughput

0.316

High

1408104

SSX3
Protein SSX3

2

0

High-throughput

0.316

High

1410546

KXDL1
KxDL motif-containing protein 1

1

0

High-throughput

0.304

High

1010545

EREP3
Protein ENTREP3

1

0

High-throughput

0.279

Low

1179879

INSY1
Inhibitory synaptic factor 1

1

0

High-throughput

0.279

Low

1207787

TMM31
Transmembrane protein 31

1

0

High-throughput

0.279

Low

1253843

TLCD5
TLC domain-containing protein 5

1

0

High-throughput

0.279

Low

1254053

R9BP
Regulator of G-protein signaling 9-binding protein

1

0

High-throughput

0.279

Low

1316008

NRSN1
Neurensin-1

1

0

High-throughput

0.279

Low

1400309

CC85A
Coiled-coil domain-containing protein 85A

1

0

High-throughput

0.279

Low

85319

RBG10
Rab GTPase-activating protein 1-like, isoform 10

1

0

High-throughput

0.249

Low

340424

YETS4
YEATS domain-containing protein 4

1

0

High-throughput

0.249

Low

855283

GPR4
G-prodeshotein coupled receptor 4

1

0

Small-scale

0.249

Low

1399378

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

0

High-throughput

0.249

Low

1439066

NCK5L
Nck-associated protein 5-like

1

0

High-throughput

0.249

Low

1445781

TUFT1
Tuftelin

1

0

High-throughput

0.249

Low

1460533

RCOR1
REST corepressor 1

1

0

High-throughput

0.249

Low

1254149

CA122
Uncharacterized protein C1orf122

1

0

High-throughput

0.232

Low

1333516

GOLM1
Golgi membrane protein 1

1

0

Small-scale

0.232

Low

1451226

CUED1
CUE domain-containing protein 1

1

0

High-throughput

0.232

Low

1460007

DPOG2
DNA polymerase subunit gamma-2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025