Interactor 1: PRS4 (P62191)
26S proteasome regulatory subunit 4 (P26s4) (26S proteasome AAA-ATPase subunit RPT2) (Proteasome 26S subunit ATPase 1)
Gene: PSMC1

Interactor 2: PSMD1 (Q99460)
26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112)
Gene: PSMD1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 0.60 0.754

The method score is based on:

Property Details
Experiments 26496610, 28514442, 33961781, 38334954, 31839598, 28292943, 35271311, 19589775, unassigned3799
Identification Methods affinity chromatography technology, cross-linking study, pull down, biochemical, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000502 - proteasome complex
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0008540 - proteasome regulatory particle, base subcomplex
and 3 others

more...

Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 440
Hs

1 953
+ At
+ At
+ Hs
+ Dm
+ Dm
+ Sp
+ Sc
+ Hs
+ Hs
+ Hs
+ At
+ At
+ At
+ At
+ At
+ Dm
+ Dm
+ Sp
+ Sc
+ Ce

Service provided by Combinatics, Japan

Last updated: 11Aug2025