HitPredict

Interactor 1: ISU1 (Q03020)
Iron sulfur cluster assembly protein 1, mitochondrial (Iron sulfur cluster scaffold protein 1)
Gene: ISU1

Interactor 2: HSP7Q (Q05931)
Iron-sulfur cluster biogenesis chaperone, mitochondrial (EC 3.6.4.10) (Heat shock protein SSQ1, mitochondrial) (Stress-seventy subfamily Q protein 1) (mtHSP70 homolog)
Gene: SSQ1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.714

Property	Details
Experiments	37968396, 25228696, 22306468, 12947415, 12756240
Identification Methods	affinity chromatography technology, pull down, surface plasmon resonance, cosedimentation in solution
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005759 - mitochondrial matrix GO:0006879 - intracellular iron ion homeostasis GO:0016226 - iron-sulfur cluster assembly
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 165 Sc			1 657
+	Sc
		985290 ISU2_YEAST (4-164): 6.63e-76: 225: 73.91		HSP7Q_YEAST (1-657): 0: 857: 100.00
+	Sc
		478466 ISU1_YEAST (1-165): 9.08e-86: 250: 100.00		HSP77_YEAST (13-651): 0: 587: 52.17
+	Sc
		478599 ISU2_YEAST (4-164): 6.63e-76: 225: 73.91		HSP77_YEAST (13-651): 0: 587: 52.17
+	Hs
		751822 ISCU_HUMAN (10-159): 1.42e-64: 196: 64.67		GRP75_HUMAN (30-655): 0: 566: 49.53
+	Ec
		459112 ISCU_ECOLI (35-160): 6.82e-63: 191: 71.43		DNAK_ECOLI (29-614): 9.98e-178: 521: 50.08
+	Sc
		495233 ISU2_YEAST (4-164): 6.63e-76: 225: 73.91		HSP72_YEAST (29-569): 6.45e-162: 481: 49.09