HitPredict

Interactor 1: TLE3 (Q04726)
Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)
Gene: TLE3

Interactor 2: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.892

Property	Details
Experiments	17353931, 24981860, 33961781, 37689310
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	TLE_N~TLE_N
Common GO terms	GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005667 - transcription regulator complex GO:0016055 - Wnt signaling pathway GO:0090090 - negative regulation of canonical Wnt signaling pathway
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 772 Hs			1 197
+	Hs
		980730 TLE3_HUMAN (1-772): 0: 583: 100.00		TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59
+	Hs
		980585 TLE3_HUMAN (1-772): 0: 583: 100.00		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		980729 TLE3_HUMAN (1-772): 0: 583: 100.00		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		980586 TLE1_HUMAN (1-772): 0: 538: 77.42		TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59
+	Hs
		980583 TLE1_HUMAN (1-772): 0: 538: 77.42		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		980772 TLE3_HUMAN (1-772): 0: 583: 100.00		Q5T3G3_HUMAN (2-197): 1.07e-99: 290: 61.43
+	Mm
		1143962 TLE4_MOUSE (1-772): 6.16e-179: 533: 80.77		TLE4_MOUSE (2-191): 3.77e-112: 338: 68.59
+	Hs
		980770 TLE3_HUMAN (1-772): 0: 583: 100.00		Q5JSZ1_HUMAN (2-192): 7.66e-95: 277: 63.11
+	Hs
		980673 TLE3_HUMAN (1-772): 0: 583: 100.00		TLE2_HUMAN (2-149): 6.71e-80: 253: 71.62
+	Mm
		1143956 TLE1_MOUSE (1-772): 1.82e-174: 522: 78.22		TLE1_MOUSE (2-197): 2.15e-101: 310: 63.00
+	Hs
		980590 TLE1_HUMAN (1-772): 0: 538: 77.42		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Mm
		925830 TLE4_MOUSE (1-772): 6.16e-179: 533: 80.77		TLE5_MOUSE (1-197): 2.66e-101: 292: 99.49
+	Hs
		980928 TLE4_HUMAN (1-772): 9.37e-179: 533: 80.65		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Mm
		925829 TLE1_MOUSE (1-772): 1.82e-174: 522: 78.22		TLE5_MOUSE (1-197): 2.66e-101: 292: 99.49
+	Hs
		980584 TLE1_HUMAN (1-772): 0: 538: 77.42		TLE2_HUMAN (2-149): 6.71e-80: 253: 71.62
+	Hs
		980674 TLE4_HUMAN (1-772): 9.37e-179: 533: 80.65		TLE2_HUMAN (2-149): 6.71e-80: 253: 71.62