HitPredict

Interactor 1: TLE3 (Q04726)
Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)
Gene: TLE3

Interactor 2: CIC (Q96RK0)
Protein capicua homolog
Gene: CIC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37689310
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 772 Hs			1 2517
+	Hs
		817955 TLE3_HUMAN (1-772): 0: 583: 100.00		SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05
+	Hs
		817954 TLE1_HUMAN (1-772): 0: 538: 77.42		SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05
+	Hs
		727851 TLE3_HUMAN (1-772): 0: 583: 100.00		SOX6_HUMAN (887-1289): 5.1e-35: 148: 16.28
+	Hs
		980850 TLE3_HUMAN (1-772): 0: 583: 100.00		MINT_HUMAN (730-2515): 3e-28: 127: 9.45
+	Hs
		727850 TLE1_HUMAN (1-772): 0: 538: 77.42		SOX6_HUMAN (887-1289): 5.1e-35: 148: 16.28
+	Hs
		980665 TLE1_HUMAN (1-772): 0: 538: 77.42		LEF1_HUMAN (929-1200): 1.93e-32: 134: 21.82
+	Hs
		727732 TLE1_HUMAN (1-772): 0: 538: 77.42		SOX5_HUMAN (833-1211): 2.27e-29: 129: 17.71
+	Hs
		980923 TLE3_HUMAN (1-772): 0: 583: 100.00		NCOR2_HUMAN (290-1816): 8.11e-14: 80.2: 8.06
+	Hs
		980914 TLE3_HUMAN (1-772): 0: 583: 100.00		SRRM2_HUMAN (291-1369): 4.76e-10: 67.9: 8.34
+	Hs
		818792 TLE1_HUMAN (1-772): 0: 538: 77.42		SOX9_HUMAN (1031-1201): 1.04e-24: 112: 23.08
+	Hs
		980825 TLE3_HUMAN (1-772): 0: 583: 100.00		TITIN_HUMAN (609-1544): 3.51e-09: 65.2: 9.85
+	Dm
		558392 GROU_DROME (1-772): 4.17e-136: 421: 57.20		CIC_DROME (1108-2440): 7.04e-49: 195: 17.66
+	Dm
		558368 GROU_DROME (1-772): 4.17e-136: 421: 57.20		PANG1_DROME (911-1183): 2.87e-46: 182: 21.74
+	Hs
		980723 TLE2_HUMAN (1-772): 4.46e-145: 445: 62.10		LEF1_HUMAN (929-1200): 1.93e-32: 134: 21.82
+	Dm
		558375 GROU_DROME (1-772): 4.17e-136: 421: 57.20		DICH_DROME (1092-1203): 9.61e-31: 128: 31.25
+	Hs
		817967 TLE5_HUMAN (1-200): 1.22e-100: 310: 62.19		SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05
+	Hs
		727734 TLE5_HUMAN (1-200): 1.22e-100: 310: 62.19		SOX5_HUMAN (833-1211): 2.27e-29: 129: 17.71
+	Ce
		137672 UNC37_CAEEL (18-686): 7.48e-82: 275: 17.09		POP1_CAEEL (959-1182): 1.17e-34: 141: 22.17
+	Hs
		993473 TLE5_HUMAN (1-200): 1.22e-100: 310: 62.19		ANR11_HUMAN (1833-2514): 2.6e-11: 72.1: 12.66
+	Mm
		1142008 TBL1R_MOUSE (560-771): 3.94e-46: 174: 15.28		Q60I23_MOUSE (1102-1308): 2.84e-56: 201: 27.40