HitPredict

Interactor 1: ACVR1 (Q04771)
Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I)
Gene: ACVR1

Interactor 2: BMPR2 (Q13873)
Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)
Gene: BMPR2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.75 1.00 0.868

The method score is based on:

Property Details
Experiments 28514442, 7791754, 7890683
Identification Methods affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Activin_recp~Activin_recp, PK_Tyr_Ser-Thr~Pkinase, Pkinase~TGF_beta_GS
Common GO terms GO:0001707 - mesoderm formation
GO:0003183 - mitral valve morphogenesis
GO:0005524 - ATP binding
GO:0005886 - plasma membrane
GO:0016310 - phosphorylation
and 12 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 509
Hs

1 1038
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024