HitPredict

Interactor 1: 1433F (Q04917)
14-3-3 protein eta (Protein AS1)
Gene: YWHAH

Interactor 2: KKCC1 (Q8N5S9)
Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha)
Gene: CAMKK1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.681

Property	Details
Experiments	32707033, 36931259, 18242179
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 246 Hs			1 505
+	Hs
		909813 1433E_HUMAN (1-244): 1.37e-141: 398: 62.71		KKCC1_HUMAN (1-505): 2.94e-159: 463: 100.00
+	Hs
		904856 1433G_HUMAN (1-246): 9.38e-138: 388: 86.99		KKCC1_HUMAN (1-505): 2.94e-159: 463: 100.00
+	Rn
		910354 1433E_RAT (1-244): 1.37e-141: 398: 62.71		KKCC1_RAT (1-505): 3.01e-153: 448: 93.66
+	Rn
		905365 1433G_RAT (1-246): 9.38e-138: 388: 86.99		KKCC1_RAT (1-505): 3.01e-153: 448: 93.66
+	Rn
		935723 1433F_RAT (1-246): 6.15e-136: 383: 99.19		KKCC1_RAT (1-505): 3.01e-153: 448: 93.66
+	At
		1280891 14337_ARATH (2-244): 2.9e-141: 398: 59.18		CIPKC_ARATH (103-501): 1.35e-132: 395: 23.47
+	At
		788672 14333_ARATH (1-244): 1.01e-141: 398: 61.38		CIPKC_ARATH (103-501): 1.35e-132: 395: 23.47
+	Dm
		90534 1433E_DROME (1-243): 7.96e-141: 396: 63.37		E1JGN0_DROME (20-415): 1.71e-125: 395: 28.29
+	At
		965360 14332_ARATH (4-244): 8.72e-141: 396: 60.91		CIPKC_ARATH (103-501): 1.35e-132: 395: 23.47
+	Hs
		681770 1433E_HUMAN (1-244): 1.37e-141: 398: 62.71		AKT1_HUMAN (60-474): 9.07e-130: 387: 21.33
+	Hs
		681766 1433G_HUMAN (1-246): 9.38e-138: 388: 86.99		AKT1_HUMAN (60-474): 9.07e-130: 387: 21.33
+	Hs
		683541 1433B_HUMAN (3-245): 2.7e-107: 311: 75.51		KKCC1_HUMAN (1-505): 2.94e-159: 463: 100.00
+	Hs
		647107 1433T_HUMAN (3-245): 7.19e-106: 307: 71.43		KKCC1_HUMAN (1-505): 2.94e-159: 463: 100.00
+	Rn
		716562 1433B_RAT (3-245): 9.89e-106: 307: 74.69		KKCC1_RAT (1-505): 3.01e-153: 448: 93.66
+	Hs
		684209 1433S_HUMAN (3-245): 2.76e-96: 283: 64.20		KKCC1_HUMAN (1-505): 2.94e-159: 463: 100.00
+	Hs
		681776 1433Z_HUMAN (3-245): 1.27e-107: 312: 74.49		AKT1_HUMAN (60-474): 9.07e-130: 387: 21.33
+	Hs
		684282 1433S_HUMAN (3-245): 2.76e-96: 283: 64.20		KKCC2_HUMAN (31-504): 7.59e-134: 401: 59.49
+	Hs
		681682 1433S_HUMAN (3-245): 2.76e-96: 283: 64.20		AKT1_HUMAN (60-474): 9.07e-130: 387: 21.33
+	Zm
		31741 A0A1D6KKP0_MAIZE (4-246): 2.26e-135: 383: 58.13		B4FIX4_MAIZE (125-439): 2.04e-54: 190: 38.41