HitPredict

Interactor 1: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Interactor 2: RNF11 (Q9Y3C5)
RING finger protein 11
Gene: RNF11

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.956

Property	Details
Experiments	19690564, 19549727, 32296183, 14562029, 15231748, unassigned1304
Identification Methods	two hybrid, pull down, two hybrid array, two hybrid prey pooling approach, enzymatic study, validated two hybrid
Interaction Type	direct interaction, physical association, ubiquitination reaction

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0005634 - nucleus GO:0006511 - ubiquitin-dependent protein catabolic process GO:0051865 - protein autoubiquitination GO:0061630 - ubiquitin protein ligase activity GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 154
+	Hs
		1490987 UB2D4_HUMAN (1-147): 3.4e-83: 242: 93.20		RNF11_HUMAN (1-154): 3.84e-43: 141: 100.00
+	Hs
		906832 UB2D1_HUMAN (1-147): 1.1e-82: 241: 89.12		RNF11_HUMAN (1-154): 3.84e-43: 141: 100.00
+	Hs
		220521 UB2D4_HUMAN (1-147): 3.4e-83: 242: 93.20		RNF13_HUMAN (77-146): 8.83e-27: 104: 33.80
+	Hs
		1294294 UB2D4_HUMAN (1-147): 3.4e-83: 242: 93.20		GOLI_HUMAN (64-146): 5.88e-26: 103: 25.30
+	Hs
		1490989 UB2D4_HUMAN (1-147): 3.4e-83: 242: 93.20		RN115_HUMAN (10-154): 1.54e-26: 103: 19.08
+	Hs
		220481 UB2D1_HUMAN (1-147): 1.1e-82: 241: 89.12		RNF13_HUMAN (77-146): 8.83e-27: 104: 33.80
+	Hs
		220490 UB2D2_HUMAN (1-147): 1.58e-82: 240: 100.00		RNF13_HUMAN (77-146): 8.83e-27: 104: 33.80
+	Hs
		906695 UB2D1_HUMAN (1-147): 1.1e-82: 241: 89.12		GOLI_HUMAN (64-146): 5.88e-26: 103: 25.30
+	Hs
		906835 UB2D1_HUMAN (1-147): 1.1e-82: 241: 89.12		RN115_HUMAN (10-154): 1.54e-26: 103: 19.08
+	Zm
		77732 B4FC97_MAIZE (1-147): 6.64e-83: 241: 79.59		B6U926_MAIZE (52-153): 1.08e-25: 101: 29.52
+	Zm
		83048 B6SZE0_MAIZE (1-147): 7.5e-83: 241: 79.59		B6U926_MAIZE (52-153): 1.08e-25: 101: 29.52
+	Hs
		906718 UB2D1_HUMAN (1-147): 1.1e-82: 241: 89.12		RN128_HUMAN (57-153): 3.1e-25: 101: 25.77
+	Hs
		1461632 UB2D4_HUMAN (1-147): 3.4e-83: 242: 93.20		RN150_HUMAN (57-146): 1.03e-24: 99: 26.67
+	Hs
		906829 UB2D1_HUMAN (1-147): 1.1e-82: 241: 89.12		RNF6_HUMAN (1-149): 1.1e-24: 100: 22.02
+	Hs
		906823 UB2D1_HUMAN (1-147): 1.1e-82: 241: 89.12		RN150_HUMAN (57-146): 1.03e-24: 99: 26.67
+	Hs
		982225 UB2D2_HUMAN (1-147): 1.58e-82: 240: 100.00		SYVN1_HUMAN (72-152): 1.78e-24: 99: 28.40
+	Hs
		1450919 UB2D4_HUMAN (1-147): 3.4e-83: 242: 93.20		RNF12_HUMAN (91-146): 1.14e-21: 91.8: 39.29
+	Hs
		906796 UB2D1_HUMAN (1-147): 1.1e-82: 241: 89.12		RNF12_HUMAN (91-146): 1.14e-21: 91.8: 39.29
+	Hs
		1435277 UB2D4_HUMAN (1-147): 3.4e-83: 242: 93.20		RN167_HUMAN (77-143): 4.98e-21: 89.1: 36.77
+	Hs
		906783 UB2D1_HUMAN (1-147): 1.1e-82: 241: 89.12		RN167_HUMAN (77-143): 4.98e-21: 89.1: 36.77