Protein: RNF6
E3 ubiquitin-protein ligase RNF6 (EC 2.3.2.27)

Gene: RNF6
Organism: Homo sapiens
Interactions: 76
UniProt ID: Q9Y252

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006355 - regulation of DNA-templated transcription

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

906829

UB2D1
Ubiquitin-conjugating enzyme E2 D1

2

20

Small-scale

0.778

High

971304

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

High-throughput

0.698

High

144204

UBE2C
Ubiquitin-conjugating enzyme E2 C

1

20

Small-scale

0.647

High

1490496

RNF6
E3 ubiquitin-protein ligase RNF6

1

18

Small-scale

0.647

High

488271

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

2

5

High-throughput

0.628

High

520466

ANDR
Androgen receptor

1

9

Small-scale

0.604

High

587260

ITF2
Transcription factor 4

2

1

Small-scale

0.586

High

711206

PTN6
Tyrosine-protein phosphatase non-receptor type 6

2

9

Small-scale

0.584

High

1048138

TLE3
Transducin-like enhancer protein 3

2

5

Small-scale

0.584

High

857365

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

1

Small-scale

0.578

High

1093209

STK4
Serine/threonine-protein kinase 4

1

3

Small-scale

0.561

High

1108818

ASAH1
Acid ceramidase

1

1

High-throughput

0.536

High

414874

P53
Cellular tumor antigen p53

1

6

Small-scale

0.501

High

1418706

LOXE3
Hydroperoxide isomerase ALOXE3

1

5

High-throughput

0.489

High

1439081

CPNE5
Copine-5

1

3

High-throughput

0.489

High

230140

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

3

High-throughput

0.481

High

283573

TAD2A
Transcriptional adapter 2-alpha

1

2

High-throughput

0.481

High

323615

TRI37
E3 ubiquitin-protein ligase TRIM37

1

12

High-throughput

0.481

High

343827

LDOC1
Protein LDOC1

1

1

High-throughput

0.481

High

572286

TRI27
Zinc finger protein RFP

1

9

High-throughput

0.481

High

618131

K1C15
Keratin, type I cytoskeletal 15

1

12

High-throughput

0.481

High

783457

TRI23
E3 ubiquitin-protein ligase TRIM23

1

20

High-throughput

0.481

High

894251

MEOX2
Homeobox protein MOX-2

1

3

High-throughput

0.481

High

1049061

REL
Proto-oncogene c-Rel

1

2

High-throughput

0.481

High

1104705

IKZF1
DNA-binding protein Ikaros

1

4

High-throughput

0.481

High

1180044

CCD57
Coiled-coil domain-containing protein 57

1

8

High-throughput

0.481

High

1206035

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

8

High-throughput

0.481

High

1224937

TENS2
Tensin-2

1

3

High-throughput

0.481

High

1350374

MIPO1
Mirror-image polydactyly gene 1 protein

1

1

High-throughput

0.481

High

1388885

HOOK2
Protein Hook homolog 2

1

11

High-throughput

0.481

High

1396199

RPGR1
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1

1

11

High-throughput

0.481

High

1407138

MDFI
MyoD family inhibitor

1

2

High-throughput

0.481

High

1420318

TSG10
Testis-specific gene 10 protein

1

11

High-throughput

0.481

High

1458251

TFP11
Tuftelin-interacting protein 11

1

1

High-throughput

0.481

High

1460662

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

15

High-throughput

0.481

High

1461229

IKZF3
Zinc finger protein Aiolos

1

4

High-throughput

0.481

High

1490498

MAGD1
Melanoma-associated antigen D1

1

12

High-throughput

0.481

High

159281

ABLM1
Actin-binding LIM protein 1

1

1

High-throughput

0.479

High

179416

ARPC2
Actin-related protein 2/3 complex subunit 2

1

1

High-throughput

0.479

High

228005

MYO1B
Unconventional myosin-Ib

1

12

High-throughput

0.479

High

325384

ZO3
Tight junction protein ZO-3

1

3

High-throughput

0.479

High

397250

ESR1
Estrogen receptor

1

9

Small-scale

0.479

High

404554

GCR
Glucocorticoid receptor

1

9

Small-scale

0.479

High

418764

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

6

High-throughput

0.479

High

476062

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

6

High-throughput

0.479

High

639417

5NTD
5'-nucleotidase

1

1

High-throughput

0.479

High

716063

GNA11
Guanine nucleotide-binding protein subunit alpha-11

1

6

High-throughput

0.479

High

765132

CTNB1
Catenin beta-1

1

3

High-throughput

0.479

High

799588

BRCA1
Breast cancer type 1 susceptibility protein

1

9

High-throughput

0.479

High

1115153

CUL4A
Cullin-4A

1

3

High-throughput

0.479

High

1117532

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

6

High-throughput

0.479

High

1287940

LDB1
LIM domain-binding protein 1

1

4

Small-scale

0.479

High

1291010

TAXB1
Tax1-binding protein 1

1

16

High-throughput

0.479

High

1359466

LMO7
LIM domain only protein 7

1

8

High-throughput

0.479

High

1371573

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

9

Small-scale

0.479

High

1371790

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

10

Small-scale

0.479

High

1387125

REPS1
RalBP1-associated Eps domain-containing protein 1

1

3

High-throughput

0.479

High

1394535

PAWR
PRKC apoptosis WT1 regulator protein

1

1

High-throughput

0.479

High

1490499

LRRF2
Leucine-rich repeat flightless-interacting protein 2

1

9

High-throughput

0.479

High

1490497

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.460

High

937976

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

Small-scale

0.458

High

1458704

RNF14
E3 ubiquitin-protein ligase RNF14

1

5

Small-scale

0.445

High

286742

STX11
Syntaxin-11

1

6

High-throughput

0.439

High

1063708

GOGA2
Golgin subfamily A member 2

1

9

High-throughput

0.439

High

1178034

MOONR
Protein moonraker

1

3

High-throughput

0.439

High

1230316

K1C40
Keratin, type I cytoskeletal 40

1

13

High-throughput

0.439

High

1238631

RINT1
RAD50-interacting protein 1

1

1

High-throughput

0.439

High

1332455

CBY2
Protein chibby homolog 2

1

1

High-throughput

0.439

High

1340387

CEP70
Centrosomal protein of 70 kDa

1

1

High-throughput

0.439

High

1461431

PNMA2
Paraneoplastic antigen Ma2

1

1

High-throughput

0.439

High

323805

AP2A2
AP-2 complex subunit alpha-2

1

10

High-throughput

0.437

High

569229

CD59
CD59 glycoprotein

1

1

High-throughput

0.437

High

1461770

COR1C
Coronin-1C

1

4

High-throughput

0.437

High

1232150

VASN
Vasorin

2

0

High-throughput

0.328

High

1328423

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025