HitPredict

Interactor 1: KPCZ (Q05513)
Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)
Gene: PRKCZ

Interactor 2: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.989

Property	Details
Experiments	25852190, 28514442, 27143478, 29491746, 31980649, 32354117, 33961781, 32707033, 15143057, 23023376, 26187466, 10747026, 34079125, 11755531, 12887891, 15870274, 20979579, 20974803, 9566925, 19850933 and 1 others more... unassigned2173
Identification Methods	affinity chromatography technology, pull down, unspecified method, proximity labelling technology, anti tag coimmunoprecipitation, two hybrid
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PB1~PB1, PB1~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0035556 - intracellular signal transduction GO:0044877 - protein-containing complex binding and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 592 Hs			1 440
+	Rn
		139612 KPCZ_RAT (1-592): 0: 686: 95.95		SQSTM_RAT (1-440): 0: 746: 90.95
+	Hs
		784001 KPCI_HUMAN (1-592): 0: 654: 69.87		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Mm
		973811 KPCZ_MOUSE (1-592): 0: 681: 95.61		SQSTM_MOUSE (1-440): 0: 731: 90.72
+	Rn
		94344 KPCI_RAT (1-592): 0: 655: 69.87		SQSTM_RAT (1-440): 0: 746: 90.95
+	Hs
		984491 KPCD_HUMAN (85-585): 1.92e-177: 519: 36.26		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Rn
		139610 KPCD_RAT (63-583): 3.17e-180: 526: 34.48		SQSTM_RAT (1-440): 0: 746: 90.95
+	Mm
		661009 KPCD_MOUSE (63-585): 9.16e-180: 525: 34.35		SQSTM_MOUSE (1-440): 0: 731: 90.72
+	Hs
		616709 KS6B1_HUMAN (227-590): 1.48e-144: 430: 35.60		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		568653 KAPCA_HUMAN (219-578): 5.07e-143: 419: 33.06		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Rn
		139624 KPCL_RAT (6-200): 4.92e-34: 139: 20.67		SQSTM_RAT (1-440): 0: 746: 90.95
+	Rn
		139611 KPCE_RAT (6-190): 3.1e-27: 118: 18.91		SQSTM_RAT (1-440): 0: 746: 90.95
+	Rn
		139620 KPCB_RAT (101-181): 2.68e-17: 87.6: 30.86		SQSTM_RAT (1-440): 0: 746: 90.95
+	Rn
		139619 KPCG_RAT (116-180): 1.79e-10: 65.9: 36.92		SQSTM_RAT (1-440): 0: 746: 90.95
+	Hs
		784009 KPCI_HUMAN (1-592): 0: 654: 69.87		NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78
+	Dm
		54642 APKC_DROME (3-592): 0: 615: 61.99		REF2P_DROME (107-170): 7.35e-20: 94: 36.92
+	Hs
		568669 KAPCA_HUMAN (219-578): 5.07e-143: 419: 33.06		NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78