HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: WIPF2 (Q8TF74)
WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein)
Gene: WIPF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.750

Property	Details
Experiments	28514442, 31980649, 33961781, 20936779, 21706016, 21988832, unassigned2173, unassigned3799
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, two hybrid pooling approach
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 440
+	Hs
		176259 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		SYNJ2_HUMAN (6-410): 2.47e-30: 126: 12.59
+	Hs
		987773 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		MINK1_HUMAN (78-414): 1.1e-28: 121: 16.76
+	Hs
		65442 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		WIPF3_HUMAN (24-435): 4.63e-21: 97.2: 29.33
+	Hs
		215914 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		SYNJ1_HUMAN (103-438): 2.35e-18: 90.3: 17.19
+	Hs
		590268 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		MUC1_HUMAN (142-437): 6.38e-11: 66.8: 11.15
+	Hs
		987833 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		PRG4_HUMAN (4-436): 1.76e-09: 62.2: 13.14
+	Hs
		67103 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		CP096_HUMAN (141-373): 4.03e-09: 61: 21.26
+	Hs
		440144 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		MINK1_HUMAN (78-414): 1.1e-28: 121: 16.76
+	Hs
		594056 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		WIPF2_HUMAN (1-440): 4.29e-32: 128: 100.00
+	Hs
		176246 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		SYNJ2_HUMAN (6-410): 2.47e-30: 126: 12.59
+	Hs
		176239 ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46		SYNJ2_HUMAN (6-410): 2.47e-30: 126: 12.59
+	Hs
		215893 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		SYNJ1_HUMAN (103-438): 2.35e-18: 90.3: 17.19
+	Hs
		594048 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		MINK1_HUMAN (78-414): 1.1e-28: 121: 16.76
+	Hs
		176277 ITSN2_HUMAN (108-216): 6.53e-13: 69.2: 18.92		SYNJ2_HUMAN (6-410): 2.47e-30: 126: 12.59
+	Hs
		439935 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		MUC1_HUMAN (142-437): 6.38e-11: 66.8: 11.15
+	Hs
		65439 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		WIPF3_HUMAN (24-435): 4.63e-21: 97.2: 29.33
+	Hs
		215903 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		SYNJ1_HUMAN (103-438): 2.35e-18: 90.3: 17.19
+	Hs
		215927 SH319_HUMAN (8-215): 6.01e-18: 83.5: 17.14		SYNJ1_HUMAN (103-438): 2.35e-18: 90.3: 17.19
+	Hs
		65447 ITSN2_HUMAN (108-216): 6.53e-13: 69.2: 18.92		WIPF3_HUMAN (24-435): 4.63e-21: 97.2: 29.33
+	Hs
		362149 ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46		MUC1_HUMAN (142-437): 6.38e-11: 66.8: 11.15