HitPredict

Interactor 1: SYNJ2 (O15056)
Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2)
Gene: SYNJ2

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.654

Property	Details
Experiments	20936779, 17474147, unassigned3799
Identification Methods	two hybrid, peptide array, two hybrid pooling approach, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1496 Hs			1 217
+	Hs
		176246 SYNJ2_HUMAN (1-1496): 0: 1390: 100.00		NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14
+	Hs
		176239 SYNJ2_HUMAN (1-1496): 0: 1390: 100.00		ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46
+	Hs
		176277 SYNJ2_HUMAN (1-1496): 0: 1390: 100.00		ITSN2_HUMAN (108-216): 6.53e-13: 69.2: 18.92
+	Hs
		176240 SYNJ2_HUMAN (1-1496): 0: 1390: 100.00		FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58
+	Hs
		176266 SYNJ2_HUMAN (1-1496): 0: 1390: 100.00		ITSN1_HUMAN (122-216): 3.21e-11: 64.2: 23.53
+	Dm
		1061418 Q5U0V7_DROME (1-1138): 0: 1050: 42.23		GRAP_DROME (1-215): 1.24e-56: 180: 62.33
+	Hs
		987815 SHIP1_HUMAN (449-1315): 6.48e-146: 479: 20.55		GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00
+	Mm
		1221257 SHIP1_MOUSE (449-1311): 1.22e-144: 476: 20.44		GRB2_MOUSE (1-217): 5.96e-71: 217: 99.54
+	Hs
		187330 SHIP2_HUMAN (454-1318): 4.81e-139: 462: 19.82		GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00
+	Hs
		594067 SHIP1_HUMAN (449-1315): 6.48e-146: 479: 20.55		NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14
+	Mm
		362455 SHIP1_MOUSE (449-1311): 1.22e-144: 476: 20.44		ABL1_MOUSE (4-139): 4.08e-22: 95.9: 35.46
+	Hs
		187238 SHIP2_HUMAN (454-1318): 4.81e-139: 462: 19.82		ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46
+	Hs
		72376 SHIP2_HUMAN (454-1318): 4.81e-139: 462: 19.82		A9UF07_HUMAN (4-139): 1.63e-21: 94: 35.46
+	Hs
		463184 SHIP1_HUMAN (449-1315): 6.48e-146: 479: 20.55		YES_HUMAN (71-215): 7.5e-12: 65.8: 16.33
+	Hs
		473456 SHIP1_HUMAN (449-1315): 6.48e-146: 479: 20.55		HCK_HUMAN (92-215): 4.76e-11: 63.5: 18.90
+	Hs
		463691 SHIP1_HUMAN (449-1315): 6.48e-146: 479: 20.55		LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47
+	Mm
		1242567 SHIP2_MOUSE (454-1318): 5.34e-143: 473: 19.96		ITSN1_MOUSE (149-216): 4.51e-11: 63.9: 27.94
+	Mm
		431370 SHIP1_MOUSE (449-1311): 1.22e-144: 476: 20.44		SRC_MOUSE (161-215): 3.32e-10: 60.8: 31.58
+	Hs
		187354 SHIP2_HUMAN (454-1318): 4.81e-139: 462: 19.82		ITSN1_HUMAN (122-216): 3.21e-11: 64.2: 23.53
+	Hs
		187257 SHIP2_HUMAN (454-1318): 4.81e-139: 462: 19.82		LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47