HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: MLXPL (Q9NP71)
Carbohydrate-responsive element-binding protein (ChREBP) (Class D basic helix-loop-helix protein 14) (bHLHd14) (MLX interactor) (MLX-interacting protein-like) (WS basic-helix-loop-helix leucine zipper protein) (WS-bHLH) (Williams-Beuren syndrome chromosomal region 14 protein)
Gene: MLXIPL

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	21988832
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 852
+	Hs
		590268 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		MUC1_HUMAN (189-842): 5.99e-32: 136: 11.76
+	Hs
		987935 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		PTN23_HUMAN (182-645): 8.67e-21: 100: 15.78
+	Hs
		987833 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		PRG4_HUMAN (136-678): 5.68e-12: 71.8: 11.31
+	Hs
		215914 GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00		SYNJ1_HUMAN (473-851): 8.2e-11: 68.3: 13.72
+	Hs
		439935 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		MUC1_HUMAN (189-842): 5.99e-32: 136: 11.76
+	Hs
		362149 ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46		MUC1_HUMAN (189-842): 5.99e-32: 136: 11.76
+	Hs
		557066 SRC_HUMAN (161-215): 3.49e-10: 60.8: 31.58		MUC1_HUMAN (189-842): 5.99e-32: 136: 11.76
+	Hs
		215893 LCK_HUMAN (3-202): 7.98e-34: 128: 28.44		SYNJ1_HUMAN (473-851): 8.2e-11: 68.3: 13.72
+	Hs
		463316 LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47		MUC1_HUMAN (189-842): 5.99e-32: 136: 11.76
+	Hs
		1205170 SH319_HUMAN (8-215): 6.01e-18: 83.5: 17.14		PTN23_HUMAN (182-645): 8.67e-21: 100: 15.78
+	Hs
		319045 LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47		K0754_HUMAN (403-851): 9.95e-26: 116: 10.77
+	Hs
		215903 NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14		SYNJ1_HUMAN (473-851): 8.2e-11: 68.3: 13.72
+	Hs
		1154169 ITSN1_HUMAN (122-216): 3.21e-11: 64.2: 23.53		PTN23_HUMAN (182-645): 8.67e-21: 100: 15.78
+	Hs
		292868 GRAP2_HUMAN (3-55): 1.97e-10: 61.3: 39.62		PTN23_HUMAN (182-645): 8.67e-21: 100: 15.78
+	Hs
		557470 SRC_HUMAN (161-215): 3.49e-10: 60.8: 31.58		PTN23_HUMAN (182-645): 8.67e-21: 100: 15.78
+	Hs
		215927 SH319_HUMAN (8-215): 6.01e-18: 83.5: 17.14		SYNJ1_HUMAN (473-851): 8.2e-11: 68.3: 13.72
+	Hs
		440738 FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58		MAGE1_HUMAN (299-648): 1.42e-13: 76.9: 18.72
+	Hs
		215925 ITSN1_HUMAN (122-216): 3.21e-11: 64.2: 23.53		SYNJ1_HUMAN (473-851): 8.2e-11: 68.3: 13.72
+	Hs
		440773 FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58		MAGL2_HUMAN (140-774): 2.76e-09: 63.3: 10.71
+	Hs
		913671 VAV2_HUMAN (3-56): 4.85e-11: 63.5: 38.18		TITIN_HUMAN (374-544): 3.36e-10: 66.5: 20.20