HitPredict

Interactor 1: TRA2B (P62995)
Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B)
Gene: TRA2B

Interactor 2: YTDC1 (Q96MU7)
YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B)
Gene: YTHDC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.654

Property	Details
Experiments	32296183, 21988832, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000381 - regulation of alternative mRNA splicing, via spliceosome GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0005634 - nucleus and 1 others more... GO:0005654 - nucleoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 288 Hs			1 727
+	Hs
		1111845 TRA2A_HUMAN (1-237): 9.37e-36: 131: 62.06		YTDC1_HUMAN (1-673): 0: 567: 100.00
+	Hs
		1398460 PPIE_HUMAN (118-201): 7.9e-27: 107: 36.91		YTDC1_HUMAN (1-673): 0: 567: 100.00
+	Hs
		1090279 ELAV2_HUMAN (52-244): 5.96e-24: 101: 20.00		YTDC1_HUMAN (1-673): 0: 567: 100.00
+	Zm
		28184 O48554_MAIZE (121-194): 3.03e-29: 110: 41.89		A0A1D6JP38_MAIZE (264-551): 6.24e-107: 346: 21.36
+	Hs
		1280756 RBM22_HUMAN (2-287): 1.83e-33: 128: 15.91		YTHD3_HUMAN (300-503): 4.26e-83: 276: 22.48
+	Hs
		1418741 RBM22_HUMAN (2-287): 1.83e-33: 128: 15.91		YTHD1_HUMAN (300-521): 7.8e-81: 270: 22.55
+	Hs
		1102144 PABP4_HUMAN (109-246): 1.66e-22: 99.2: 21.28		YTHD2_HUMAN (300-520): 2.51e-88: 290: 23.71
+	Hs
		550545 PABP1_HUMAN (109-246): 3.02e-22: 98.4: 21.99		YTHD2_HUMAN (300-520): 2.51e-88: 290: 23.71
+	Hs
		1432517 PABP3_HUMAN (109-246): 4.58e-20: 91.8: 19.86		YTHD2_HUMAN (300-520): 2.51e-88: 290: 23.71
+	Hs
		1127287 RBM39_HUMAN (15-248): 1.55e-18: 87.2: 21.83		YTHD2_HUMAN (300-520): 2.51e-88: 290: 23.71
+	Hs
		1102005 PABP4_HUMAN (109-246): 1.66e-22: 99.2: 21.28		YTHD3_HUMAN (300-503): 4.26e-83: 276: 22.48
+	Hs
		550345 PABP1_HUMAN (109-246): 3.02e-22: 98.4: 21.99		YTHD3_HUMAN (300-503): 4.26e-83: 276: 22.48
+	Hs
		1102082 PABP4_HUMAN (109-246): 1.66e-22: 99.2: 21.28		YTHD1_HUMAN (300-521): 7.8e-81: 270: 22.55
+	Hs
		550452 PABP1_HUMAN (109-246): 3.02e-22: 98.4: 21.99		YTHD1_HUMAN (300-521): 7.8e-81: 270: 22.55
+	Hs
		1029006 TIAR_HUMAN (73-272): 5.49e-20: 90.6: 14.00		YTHD3_HUMAN (300-503): 4.26e-83: 276: 22.48
+	Hs
		1418724 PABP3_HUMAN (109-246): 4.58e-20: 91.8: 19.86		YTHD1_HUMAN (300-521): 7.8e-81: 270: 22.55
+	Hs
		1127139 RBM39_HUMAN (15-248): 1.55e-18: 87.2: 21.83		YTHD1_HUMAN (300-521): 7.8e-81: 270: 22.55