HitPredict

Interactor 1: ACTN3 (Q08043)
Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein)
Gene: ACTN3

Interactor 2: ABI3 (Q9P2A4)
ABI gene family member 3 (New molecule including SH3) (Nesh)
Gene: ABI3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	25416956
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0030036 - actin cytoskeleton organization GO:0051015 - actin filament binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 901 Hs			1 366
+	Hs
		70406 B2R8Y4_HUMAN (1-901): 0: 684: 99.45		ABI3_HUMAN (1-366): 1.12e-87: 270: 100.00
+	Hs
		70397 B2R8Y4_HUMAN (1-901): 0: 684: 99.45		NEBL_HUMAN (13-363): 2.92e-35: 139: 14.13
+	Hs
		282325 ACTN3_HUMAN (1-901): 0: 680: 100.00		NEBL_HUMAN (13-363): 2.92e-35: 139: 14.13
+	Hs
		211580 ACTN4_HUMAN (25-901): 0: 651: 74.26		SRC8_HUMAN (40-363): 2.07e-42: 157: 16.12
+	Hs
		521521 ACTN1_HUMAN (19-901): 0: 687: 77.82		GRB2_HUMAN (312-363): 4.03e-14: 72.7: 28.30
+	Hs
		725677 ACTN2_HUMAN (13-901): 0: 663: 79.98		ABI1_HUMAN (124-363): 7.31e-21: 95.5: 24.49
+	Hs
		211557 ACTN4_HUMAN (25-901): 0: 651: 74.26		GRB2_HUMAN (312-363): 4.03e-14: 72.7: 28.30
+	Hs
		963325 SPTB2_HUMAN (227-791): 2.62e-11: 70: 10.78		SRC8_HUMAN (40-363): 2.07e-42: 157: 16.12
+	Hs
		963409 SPTB2_HUMAN (227-791): 2.62e-11: 70: 10.78		PACN1_HUMAN (11-363): 5.47e-37: 140: 12.67
+	Hs
		924482 SPTB2_HUMAN (227-791): 2.62e-11: 70: 10.78		GRB2_HUMAN (312-363): 4.03e-14: 72.7: 28.30
+	Hs
		963335 SPTB2_HUMAN (227-791): 2.62e-11: 70: 10.78		ITSN1_HUMAN (205-363): 8.02e-10: 62.8: 15.85