HitPredict

Interactor 1: ACTC (P68032)
Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
Gene: ACTC1

Interactor 2: FMN2 (Q9NZ56)
Formin-2
Gene: FMN2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30890647
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~FH2
Common GO terms	GO:0005829 - cytosol GO:0015629 - actin cytoskeleton GO:0043066 - negative regulation of apoptotic process
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 1722
+	Hs
		953147 ACTB_HUMAN (4-377): 0: 598: 94.12		FMN2_HUMAN (1-1722): 1.11e-164: 547: 100.00
+	Hs
		993358 ACTG_HUMAN (4-377): 0: 598: 94.39		FMN2_HUMAN (1-1722): 1.11e-164: 547: 100.00
+	Hs
		252442 ACTC_HUMAN (1-377): 0: 599: 100.00		DIAP1_HUMAN (1105-1720): 1.12e-110: 385: 21.81
+	Hs
		252430 ACTB_HUMAN (4-377): 0: 598: 94.12		DIAP1_HUMAN (1105-1720): 1.12e-110: 385: 21.81
+	Hs
		953134 ACTB_HUMAN (4-377): 0: 598: 94.12		DIAP3_HUMAN (1269-1720): 1.7e-107: 374: 22.65
+	Hs
		977747 ACTA_HUMAN (1-377): 0: 597: 98.41		FMNL3_HUMAN (1290-1721): 5.45e-107: 369: 17.89
+	Hs
		953207 ACTB_HUMAN (4-377): 0: 598: 94.12		DAAM1_HUMAN (1270-1718): 3.45e-103: 359: 21.32
+	Hs
		993299 ACTG_HUMAN (4-377): 0: 598: 94.39		FMNL2_HUMAN (1290-1721): 8.44e-95: 334: 19.41
+	Hs
		953218 ACTB_HUMAN (4-377): 0: 598: 94.12		FHOD1_HUMAN (1035-1708): 4.57e-84: 303: 18.85
+	Hs
		993405 ACTG_HUMAN (4-377): 0: 598: 94.39		FHOD1_HUMAN (1035-1708): 4.57e-84: 303: 18.85
+	Dm
		386985 ACT2_DROME (1-377): 0: 596: 94.16		Q8SY43_DROME (1271-1708): 8.18e-75: 276: 20.54