HitPredict

Interactor 1: SRSF4 (Q08170)
Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4)
Gene: SRSF4

Interactor 2: PRP4K (Q13523)
Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 kinase) (PRP4 pre-mRNA-processing factor 4 homolog)
Gene: PRP4K

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 494 Hs			1 1007
+	Hs
		992756 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		PRP4K_HUMAN (1-1007): 1.03e-174: 538: 100.00
+	Hs
		1028893 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		PRP4K_HUMAN (1-1007): 1.03e-174: 538: 100.00
+	Hs
		1028642 SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85		PRP4K_HUMAN (1-1007): 1.03e-174: 538: 100.00
+	Hs
		992970 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		CDK12_HUMAN (31-1005): 5.97e-121: 405: 15.92
+	Hs
		1029138 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		CDK12_HUMAN (31-1005): 5.97e-121: 405: 15.92
+	Hs
		993856 SRSF4_HUMAN (1-468): 4.56e-48: 174: 100.00		CDK12_HUMAN (31-1005): 5.97e-121: 405: 15.92
+	Hs
		1028854 SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85		CDK12_HUMAN (31-1005): 5.97e-121: 405: 15.92
+	Hs
		516362 PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50		CDK2_HUMAN (684-955): 5.29e-121: 373: 23.45
+	At
		621700 RB45A_ARATH (4-175): 1.59e-20: 95.4: 17.02		CDKA1_ARATH (684-1005): 2.47e-125: 384: 24.70
+	Zm
		11850 A0A1D6II08_MAIZE (2-370): 2.75e-16: 83.5: 11.43		A0A1D6FHK3_MAIZE (687-1005): 7.94e-119: 371: 27.69
+	Hs
		833870 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		CLK2_HUMAN (670-1002): 2.93e-38: 152: 31.05
+	Hs
		992764 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		DYR1A_HUMAN (677-1005): 2.55e-37: 152: 32.65
+	Hs
		1028900 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		DYR1A_HUMAN (677-1005): 2.55e-37: 152: 32.65
+	Hs
		833875 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		CLK2_HUMAN (670-1002): 2.93e-38: 152: 31.05
+	Hs
		1028543 SRSF9_HUMAN (3-216): 2.36e-52: 178: 36.53		DYR1A_HUMAN (677-1005): 2.55e-37: 152: 32.65
+	Hs
		833871 SRSF4_HUMAN (1-468): 4.56e-48: 174: 100.00		CLK2_HUMAN (670-1002): 2.93e-38: 152: 31.05
+	Hs
		993712 SRSF4_HUMAN (1-468): 4.56e-48: 174: 100.00		DYR1A_HUMAN (677-1005): 2.55e-37: 152: 32.65
+	Hs
		1028649 SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85		DYR1A_HUMAN (677-1005): 2.55e-37: 152: 32.65
+	Hs
		516416 PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50		CLK2_HUMAN (670-1002): 2.93e-38: 152: 31.05
+	Hs
		516508 PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50		DYR1A_HUMAN (677-1005): 2.55e-37: 152: 32.65