HitPredict

Interactor 1: SRSF4 (Q08170)
Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4)
Gene: SRSF4

Interactor 2: DYR1A (Q13627)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB)
Gene: DYRK1A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	14623875
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016607 - nuclear speck GO:0048025 - negative regulation of mRNA splicing, via spliceosome
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 494 Hs			1 763
+	Hs
		992764 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		1028900 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		1028543 SRSF9_HUMAN (3-216): 2.36e-52: 178: 36.53		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		1028649 SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		516508 PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		1031320 PABP4_HUMAN (100-185): 3.19e-11: 67.7: 19.78		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		681823 SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85		AKT1_HUMAN (38-466): 4.44e-117: 363: 19.42
+	Hs
		516362 PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50		CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85
+	At
		621700 RB45A_ARATH (4-175): 1.59e-20: 95.4: 17.02		CDKA1_ARATH (156-482): 1.46e-122: 370: 26.65
+	Zm
		11850 A0A1D6II08_MAIZE (2-370): 2.75e-16: 83.5: 11.43		A0A1D6FHK3_MAIZE (103-525): 7.64e-118: 362: 22.50
+	Sc
		376610 PABP_YEAST (72-188): 2.61e-10: 64.6: 14.75		YAK1_YEAST (19-586): 3.53e-116: 371: 29.05
+	At
		51039 RSZ33_ARATH (3-75): 5.24e-09: 59.3: 53.43		A1L4Y9_ARATH (129-483): 3.59e-56: 199: 32.90
+	At
		847177 RSZ33_ARATH (3-75): 5.24e-09: 59.3: 53.43		AFC3_ARATH (129-483): 3.59e-56: 199: 32.90
+	Zm
		33400 A0A1D6M1U3_MAIZE (100-205): 2e-12: 70.4: 17.59		A0A1D6L2E7_MAIZE (129-479): 1.14e-46: 181: 33.24