HitPredict

Interactor 1: SRSF4 (Q08170)
Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4)
Gene: SRSF4

Interactor 2: LARP7 (Q4G0J3)
La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S)
Gene: LARP7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	26725010, 29845934, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	La~RRM_1, RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006397 - mRNA processing GO:0008380 - RNA splicing
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 494 Hs			1 582
+	Hs
		992797 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		1028941 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Mm
		985651 SRSF1_MOUSE (3-166): 2.36e-57: 192: 41.42		LARP7_MOUSE (8-582): 1.3e-120: 370: 79.20
+	Hs
		516478 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	Hs
		992823 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		LARP4_HUMAN (22-216): 3.23e-40: 157: 21.32
+	Hs
		403211 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		LA_HUMAN (24-365): 5.96e-44: 163: 18.83
+	Hs
		992916 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		MK67I_HUMAN (93-358): 1.25e-39: 148: 19.42
+	Hs
		992864 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		LAR4B_HUMAN (2-216): 8.48e-36: 145: 17.02
+	Hs
		516493 SRSF9_HUMAN (3-216): 2.36e-52: 178: 36.53		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	Hs
		1029076 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		MK67I_HUMAN (93-358): 1.25e-39: 148: 19.42
+	Sc
		376750 NOP4_YEAST (1-492): 1.19e-52: 190: 11.82		PABP_YEAST (9-243): 8.44e-33: 134: 13.47
+	Hs
		992875 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		PABP5_HUMAN (12-206): 7.64e-32: 128: 14.15
+	Hs
		474020 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		PAB4L_HUMAN (1-203): 9.24e-35: 136: 11.85
+	Mm
		857340 SRSF1_MOUSE (3-166): 2.36e-57: 192: 41.42		TIA1_MOUSE (120-325): 5.06e-24: 106: 13.94
+	Hs
		992961 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		RBM28_HUMAN (40-343): 2.97e-23: 106: 13.84
+	Mm
		857324 Q542V3_MOUSE (1-468): 2.02e-54: 191: 80.38		TIA1_MOUSE (120-325): 5.06e-24: 106: 13.94
+	Hs
		1029129 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		RBM28_HUMAN (40-343): 2.97e-23: 106: 13.84
+	Hs
		992815 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		LARP1_HUMAN (29-114): 6.35e-13: 73.8: 40.23
+	Hs
		1028964 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		LARP1_HUMAN (29-114): 6.35e-13: 73.8: 40.23
+	Hs
		1028557 SRSF9_HUMAN (3-216): 2.36e-52: 178: 36.53		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50