HitPredict

Interactor 1: SRSF4 (Q08170)
Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4)
Gene: SRSF4

Interactor 2: DOT1L (Q8TEK3)
Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4)
Gene: DOT1L

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35850772
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 494 Hs			1 1537
+	Hs
		992856 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		DOT1L_HUMAN (1-1537): 0: 2441: 100.00
+	Hs
		1029013 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		DOT1L_HUMAN (1-1537): 0: 2441: 100.00
+	Hs
		1028584 SRSF9_HUMAN (3-216): 2.36e-52: 178: 36.53		DOT1L_HUMAN (1-1537): 0: 2441: 100.00
+	Hs
		1028749 SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85		DOT1L_HUMAN (1-1537): 0: 2441: 100.00
+	Hs
		516603 PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50		DOT1L_HUMAN (1-1537): 0: 2441: 100.00
+	Hs
		1031399 PABP4_HUMAN (100-185): 3.19e-11: 67.7: 19.78		DOT1L_HUMAN (1-1537): 0: 2441: 100.00
+	Hs
		680470 TIA1_HUMAN (98-188): 6.06e-10: 63.1: 17.02		DOT1L_HUMAN (1-1537): 0: 2441: 100.00