HitPredict

Interactor 1: PP2AA (P67775)
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C)
Gene: PPP2CA

Interactor 2: AKT3 (Q9Y243)
RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2)
Gene: AKT3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	27563096, 18160256
Identification Methods	affinity chromatography technology, pull down, phosphatase assay
Interaction Type	physical association, direct interaction, dephosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0035556 - intracellular signal transduction
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 309 Hs			1 479
+	Mm
		728515 PP2AA_MOUSE (1-309): 0: 528: 99.68		AKT1_MOUSE (1-477): 0: 566: 82.08
+	Hs
		728574 PP2AA_HUMAN (1-309): 0: 529: 100.00		AKT2_HUMAN (1-479): 0: 564: 75.78
+	Hs
		728156 PP2AA_HUMAN (1-309): 0: 529: 100.00		AKT1_HUMAN (1-477): 0: 563: 82.29
+	Mm
		728514 PP1A_MOUSE (5-296): 0: 503: 46.84		AKT1_MOUSE (1-477): 0: 566: 82.08
+	Hs
		728070 PP1G_HUMAN (7-306): 0: 505: 45.96		AKT1_HUMAN (1-477): 0: 563: 82.29
+	Hs
		728144 PP1A_HUMAN (5-296): 0: 503: 46.51		AKT1_HUMAN (1-477): 0: 563: 82.29
+	Dm
		661944 PP2A_DROME (1-309): 0: 524: 93.85		AKT1_DROME (3-473): 0: 530: 62.50
+	Hs
		994407 PP2AA_HUMAN (1-309): 0: 529: 100.00		KS6B2_HUMAN (114-477): 6.8e-150: 437: 41.03
+	Hs
		122943 PP2AA_HUMAN (1-309): 0: 529: 100.00		SGK1_HUMAN (102-477): 5.73e-149: 433: 47.48
+	Hs
		436642 PP1A_HUMAN (5-296): 0: 503: 46.51		KPCB_HUMAN (13-476): 1.22e-151: 448: 36.63
+	Sp
		661365 PP2A2_SCHPO (5-309): 0: 504: 79.02		GAD8_SCHPO (121-477): 1.86e-147: 434: 41.74