HitPredict

Interactor 1: ACTC (P68032)
Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
Gene: ACTC1

Interactor 2: TMOD3 (Q9NYL9)
Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod)
Gene: TMOD3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.867

Property	Details
Experiments	30890647, 28514442, 33961781
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Tropomodulin
Common GO terms	GO:0007015 - actin filament organization
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 352
+	Hs
		953144 ACTB_HUMAN (4-377): 0: 598: 94.12		TMOD3_HUMAN (1-352): 1.8e-139: 401: 100.00
+	Hs
		977843 ACTA_HUMAN (1-377): 0: 597: 98.41		TMOD3_HUMAN (1-352): 1.8e-139: 401: 100.00
+	Hs
		995859 ACTC_HUMAN (1-377): 0: 599: 100.00		TMOD2_HUMAN (1-352): 1.27e-131: 381: 75.85
+	Hs
		953148 ACTB_HUMAN (4-377): 0: 598: 94.12		TMOD2_HUMAN (1-352): 1.27e-131: 381: 75.85
+	Hs
		993360 ACTG_HUMAN (4-377): 0: 598: 94.39		TMOD2_HUMAN (1-352): 1.27e-131: 381: 75.85
+	Hs
		701965 ACTB_HUMAN (4-377): 0: 598: 94.12		TMOD1_HUMAN (3-348): 1.35e-127: 371: 62.14
+	Hs
		701969 ACTG_HUMAN (4-377): 0: 598: 94.39		TMOD1_HUMAN (3-348): 1.35e-127: 371: 62.14
+	Hs
		701967 ACTA_HUMAN (1-377): 0: 597: 98.41		TMOD1_HUMAN (3-348): 1.35e-127: 371: 62.14
+	Dm
		69056 ACT1_DROME (1-377): 0: 598: 94.43		A8JRH3_DROME (5-350): 8.27e-101: 308: 31.82
+	Hs
		995664 ACTC_HUMAN (1-377): 0: 599: 100.00		NLRC3_HUMAN (189-312): 2.92e-23: 103: 21.77
+	Hs
		947337 ACTB_HUMAN (4-377): 0: 598: 94.12		NAL12_HUMAN (215-351): 6.87e-10: 62.5: 15.71