HitPredict

Interactor 1: TMOD1 (P28289)
Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod)
Gene: TMOD1

Interactor 2: ACTA (P62736)
Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form]
Gene: ACTA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37071682
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~Tropomodulin
Common GO terms	GO:0005829 - cytosol
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 359 Hs			1 377
+	Hs
		1201077 TMOD3_HUMAN (1-345): 1.44e-153: 437: 62.14		ACTBL_HUMAN (4-377): 0: 712: 87.97
+	Hs
		701965 TMOD1_HUMAN (1-359): 1.53e-167: 473: 100.00		ACTB_HUMAN (4-377): 0: 594: 94.12
+	Hs
		701969 TMOD1_HUMAN (1-359): 1.53e-167: 473: 100.00		ACTG_HUMAN (4-377): 0: 594: 94.39
+	Hs
		995853 TMOD3_HUMAN (1-345): 1.44e-153: 437: 62.14		ACTC_HUMAN (1-377): 0: 595: 98.41
+	Hs
		953144 TMOD3_HUMAN (1-345): 1.44e-153: 437: 62.14		ACTB_HUMAN (4-377): 0: 594: 94.12
+	Hs
		977843 TMOD3_HUMAN (1-345): 1.44e-153: 437: 62.14		ACTA_HUMAN (1-377): 0: 593: 100.00
+	Hs
		995859 TMOD2_HUMAN (1-345): 8.94e-146: 417: 59.54		ACTC_HUMAN (1-377): 0: 595: 98.41
+	Hs
		953148 TMOD2_HUMAN (1-345): 8.94e-146: 417: 59.54		ACTB_HUMAN (4-377): 0: 594: 94.12
+	Hs
		993360 TMOD2_HUMAN (1-345): 8.94e-146: 417: 59.54		ACTG_HUMAN (4-377): 0: 594: 94.39
+	Dm
		69056 A8JRH3_DROME (3-354): 1.95e-119: 357: 36.87		ACT1_DROME (1-377): 0: 594: 93.90
+	Mm
		1295881 NLRP3_MOUSE (185-347): 3.59e-11: 66.7: 17.37		ACTBL_MOUSE (4-377): 0: 721: 89.04
+	Hs
		995664 NLRC3_HUMAN (182-309): 4.84e-18: 87.8: 24.22		ACTC_HUMAN (1-377): 0: 595: 98.41
+	Hs
		947337 NAL12_HUMAN (180-323): 7.15e-12: 69: 19.18		ACTB_HUMAN (4-377): 0: 594: 94.12