Protein: ACK1
Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Non-receptor protein tyrosine kinase Ack) (Tyrosine kinase non-receptor protein 2)

Gene: ACK1, Tnk2
Organism: Mus musculus
Interactions: 76
UniProt ID: O54967

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

236875

ACK1
Activated CDC42 kinase 1

2

20

Small-scale

0.754

High

236878

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related 1; Ubiquitin-related 2]

2

11

Small-scale

0.727

High

236934

NCK1
SH2/SH3 adapter protein Nck1

1

20

Small-scale

0.665

High

236879

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

11

Small-scale

0.618

High

236884

MPRIP
Myosin phosphatase Rho-interacting protein

1

20

Small-scale

0.618

High

236892

LIMC1
LIM and calponin homology domains-containing protein 1

1

8

Small-scale

0.618

High

236895

TAOK1
Serine/threonine-protein kinase TAO1

1

20

Small-scale

0.618

High

236902

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

20

Small-scale

0.618

High

236904

SRBS1
Sorbin and SH3 domain-containing protein 1

1

20

Small-scale

0.618

High

236909

RHG21
Rho GTPase-activating protein 21

1

20

Small-scale

0.618

High

236915

LRRC7
Leucine-rich repeat-containing protein 7

1

12

Small-scale

0.618

High

236919

MYPT2
Protein phosphatase 1 regulatory subunit 12B

1

14

Small-scale

0.618

High

236921

FRM4A
FERM domain-containing protein 4A

1

20

Small-scale

0.618

High

236925

ANK2
Ankyrin-2

1

11

Small-scale

0.618

High

236927

MICA3
[F-actin]-monooxygenase MICAL3

1

20

Small-scale

0.618

High

236932

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

20

Small-scale

0.618

High

236935

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

17

Small-scale

0.618

High

236939

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.618

High

236942

DREB
Drebrin

1

20

Small-scale

0.618

High

236945

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

1

20

Small-scale

0.618

High

236946

ZO2
Tight junction protein 2

1

20

Small-scale

0.618

High

236905

CLH1
Clathrin heavy chain 1

2

7

Small-scale

0.584

High

236898

LCP2
Lymphocyte cytosolic protein 2

1

20

Small-scale

0.553

High

236918

AFAP1
Actin filament-associated protein 1

1

2

Small-scale

0.553

High

236920

SH2D7
SH2 domain-containing protein 7

1

20

Small-scale

0.553

High

236936

RAI14
Ankycorbin

1

20

Small-scale

0.553

High

236888

KCMA1
Calcium-activated potassium channel subunit alpha-1

1

12

Small-scale

0.536

High

236891

PSMD1
26S proteasome non-ATPase regulatory subunit 1

2

2

Small-scale

0.533

High

205670

CTND2
Catenin delta-2

1

20

Small-scale

0.479

High

236876

DNM3A
DNA

1

1

Small-scale

0.479

High

236877

NFM
Neurofilament medium polypeptide

1

20

Small-scale

0.479

High

236880

MAP1B
Microtubule-associated protein 1B

1

20

Small-scale

0.479

High

236881

MAP4
Microtubule-associated protein 4

1

20

Small-scale

0.479

High

236882

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

20

Small-scale

0.479

High

236885

ARVC
Splicing regulator ARVCF

1

20

Small-scale

0.479

High

236886

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

7

Small-scale

0.479

High

236889

STING
Stimulator of interferon genes protein

1

3

High-throughput

0.479

High

236893

GRIN1
G protein-regulated inducer of neurite outgrowth 1

1

20

Small-scale

0.479

High

236899

SC6A4
Sodium-dependent serotonin transporter

1

8

High-throughput

0.479

High

236900

CTNA2
Catenin alpha-2

1

8

Small-scale

0.479

High

236901

MYH10
Myosin-10

1

9

Small-scale

0.479

High

236903

TIF1B
Transcription intermediary factor 1-beta

1

19

Small-scale

0.479

High

236906

PKP4
Plakophilin-4

1

20

Small-scale

0.479

High

236907

RHG23
Rho GTPase-activating protein 23

1

20

Small-scale

0.479

High

236913

DLGP3
Disks large-associated protein 3

1

13

Small-scale

0.479

High

236914

MAP6
Microtubule-associated protein 6

1

19

Small-scale

0.479

High

236916

CAMP3
Calmodulin-regulated spectrin-associated protein 3

1

20

Small-scale

0.479

High

236928

MATR3
Matrin-3

1

4

Small-scale

0.479

High

236929

SVIL
Supervillin

1

7

Small-scale

0.479

High

236930

SGIP1
SH3-containing GRB2-like protein 3-interacting protein 1

1

20

Small-scale

0.479

High

236931

MYH9
Myosin-9

1

9

Small-scale

0.479

High

236937

LIMA1
LIM domain and actin-binding protein 1

1

17

Small-scale

0.479

High

236938

MY18A
Unconventional myosin-XVIIIa

1

13

Small-scale

0.479

High

236940

SRCN1
SRC kinase signaling inhibitor 1

1

10

Small-scale

0.479

High

236941

KI21B
Kinesin-like protein KIF21B

1

7

Small-scale

0.479

High

236944

AFAD
Afadin

1

20

Small-scale

0.479

High

59382

AJM1
Apical junction component 1 homolog

1

0

Small-scale

0.458

High

236890

MAP9
Microtubule-associated protein 9

1

0

Small-scale

0.458

High

236917

DDHD1
Phospholipase DDHD1

1

0

Small-scale

0.458

High

236922

PPR18
Phostensin

1

0

Small-scale

0.458

High

236926

AMER2
APC membrane recruitment protein 2

1

0

Small-scale

0.458

High

59177

A2A9M5
Dedicator of cytokinesis 7

1

11

Small-scale

0.437

High

236883

CAD10
Cadherin-10

1

20

Small-scale

0.437

High

236887

ENAH
Protein enabled homolog

1

20

Small-scale

0.437

High

236894

Q3UPB2
Cytospin-B

1

14

Small-scale

0.437

High

236896

CRACD
Capping protein-inhibiting regulator of actin dynamics

1

20

Small-scale

0.437

High

236897

LEO1
RNA polymerase-associated protein LEO1

1

1

Small-scale

0.437

High

236908

CE170
Centrosomal protein of 170 kDa

1

20

Small-scale

0.437

High

236911

MTCL3
Microtubule cross-linking factor 3

1

20

Small-scale

0.437

High

236912

SMRC2
SWI/SNF complex subunit SMARCC2

1

16

Small-scale

0.437

High

236923

NLGN3
Neuroligin-3

1

2

Small-scale

0.437

High

236924

DEN2A
DENN domain-containing protein 2A

1

15

Small-scale

0.437

High

236933

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

1

Small-scale

0.437

High

236943

ADDB
Beta-adducin

1

10

Small-scale

0.437

High

236910

FBX41
F-box only protein 41

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025