Protein: SYPH
Synaptophysin (Major synaptic vesicle protein p38)

Gene: SYPH, SYP
Organism: Homo sapiens
Interactions: 128
UniProt ID: P08247

Gene Ontology (top 5):
GO:0006897 - endocytosis
GO:0008021 - synaptic vesicle
GO:0015485 - cholesterol binding
GO:0016188 - synaptic vesicle maturation
GO:0030672 - synaptic vesicle membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

439191

NUFP1
FMR1-interacting protein NUFIP1

3

0

High-throughput

0.638

High

229618

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

2

1

High-throughput

0.628

High

254318

ATP9A
Probable phospholipid-transporting ATPase IIA

2

0

High-throughput

0.602

High

439108

HD
Huntingtin

2

1

High-throughput

0.588

High

439157

STAR4
StAR-related lipid transfer protein 4

2

0

High-throughput

0.580

High

439099

GDC
Solute carrier family 25 member 16

2

2

High-throughput

0.574

High

439116

S20A2
Sodium-dependent phosphate transporter 2

2

1

High-throughput

0.574

High

439166

SCMC3
Mitochondrial adenyl nucleotide antiporter SLC25A23

2

1

High-throughput

0.574

High

439168

SFXN3
Sideroflexin-3

2

1

High-throughput

0.574

High

439179

S38AA
Solute carrier family 38 member 10

2

1

High-throughput

0.574

High

439101

PPIF
Peptidyl-prolyl cis-trans isomerase F, mitochondrial

2

1

High-throughput

0.553

High

439112

ARFP2
Arfaptin-2

2

1

High-throughput

0.553

High

439144

RBFA
Putative ribosome-binding factor A, mitochondrial

2

1

High-throughput

0.553

High

439156

MID49
Mitochondrial dynamics protein MID49

2

1

High-throughput

0.553

High

439170

LNP
Endoplasmic reticulum junction formation protein lunapark

2

1

High-throughput

0.553

High

439182

MID51
Mitochondrial dynamics protein MIEF1

2

1

High-throughput

0.553

High

439113

VAMP2
Vesicle-associated membrane protein 2

1

6

High-throughput

0.536

High

439153

LPAR1
Lysophosphatidic acid receptor 1

1

1

High-throughput

0.536

High

212586

AP1G1
AP-1 complex subunit gamma-1

1

0

Small-scale

0.529

High

393957

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.515

High

255275

HIP1R
Huntingtin-interacting protein 1-related protein

1

0

High-throughput

0.513

High

439111

GPM6A
Neuronal membrane glycoprotein M6-a

1

0

High-throughput

0.513

High

439117

CLN3
Battenin

1

0

High-throughput

0.513

High

439098

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.493

High

217127

EXTL3
Exostosin-like 3

1

1

High-throughput

0.489

High

439124

EXT1
Exostosin-1

1

1

High-throughput

0.489

High

439136

S27A4
Long-chain fatty acid transport protein 4

1

1

High-throughput

0.489

High

439137

S27A1
Long-chain fatty acid transport protein 1

1

1

High-throughput

0.489

High

439139

PCAT2
Lysophosphatidylcholine acyltransferase 2

1

1

High-throughput

0.489

High

439141

GPAT4
Glycerol-3-phosphate acyltransferase 4

1

1

High-throughput

0.489

High

439150

S20A1
Sodium-dependent phosphate transporter 1

1

1

High-throughput

0.489

High

439163

SFXN2
Sideroflexin-2

1

1

High-throughput

0.489

High

439180

TPC
Mitochondrial thiamine pyrophosphate carrier

1

2

High-throughput

0.489

High

439187

MTCH1
Mitochondrial carrier homolog 1

1

3

High-throughput

0.489

High

439200

ORNT1
Mitochondrial ornithine transporter 1

1

3

High-throughput

0.489

High

439176

DNJC5
DnaJ homolog subfamily C member 5

1

0

High-throughput

0.480

High

46644

A0A384ME17
Elongation factor Tu

1

1

High-throughput

0.470

High

439120

TBB2A
Tubulin beta-2A chain

1

1

High-throughput

0.470

High

439154

Q96AL5
PBX3 protein

1

3

High-throughput

0.470

High

439125

STX1A
Syntaxin-1A

1

0

Small-scale

0.458

High

439194

RAB26
Ras-related protein Rab-26

1

0

Small-scale

0.458

High

439142

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

2

Small-scale

0.457

High

439106

PBX3
Pre-B-cell leukemia transcription factor 3

1

3

High-throughput

0.439

High

439110

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.439

High

235465

VINEX
Vinexin

1

1

Small-scale

0.437

High

439171

SRCN1
SRC kinase signaling inhibitor 1

1

1

Small-scale

0.437

High

439097

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

439126

DGUOK
Deoxyguanosine kinase, mitochondrial

3

0

High-throughput

0.347

High

120808

APBB1
Amyloid beta precursor protein binding family B member 1

3

0

High-throughput

0.345

High

439197

SHLB1
Endophilin-B1

3

0

High-throughput

0.344

High

439102

GLPK
Glycerol kinase

2

0

High-throughput

0.328

High

439114

PTPS
6-pyruvoyl tetrahydrobiopterin synthase

2

0

High-throughput

0.328

High

439115

RN5A
2-5A-dependent ribonuclease

2

0

High-throughput

0.328

High

439131

TMTC4
Protein O-mannosyl-transferase TMTC4

2

0

High-throughput

0.328

High

439143

T183A
Transmembrane protein 183A

2

0

High-throughput

0.328

High

439146

TM87A
Transmembrane protein 87A

2

0

High-throughput

0.328

High

439148

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

2

0

High-throughput

0.328

High

439169

SGPP1
Sphingosine-1-phosphate phosphatase 1

2

0

High-throughput

0.328

High

439174

ARV1
Protein ARV1

2

0

High-throughput

0.328

High

439181

MRS2
Magnesium transporter MRS2 homolog, mitochondrial

2

0

High-throughput

0.328

High

224685

SSX5
Protein SSX5

2

0

High-throughput

0.316

High

238135

PLIN3
Perilipin-3

2

0

High-throughput

0.316

High

254662

PTCD1
Pentatricopeptide repeat-containing protein 1, mitochondrial

2

0

High-throughput

0.316

High

256722

CAND2
Cullin-associated NEDD8-dissociated protein 2

2

0

High-throughput

0.316

High

311881

SYFM
Phenylalanine--tRNA ligase, mitochondrial

2

0

High-throughput

0.316

High

328249

BY55
CD160 antigen

2

0

High-throughput

0.316

High

439105

GDNF
Glial cell line-derived neurotrophic factor

2

0

High-throughput

0.316

High

439109

PTN9
Tyrosine-protein phosphatase non-receptor type 9

2

0

High-throughput

0.316

High

439119

SNX1
Sorting nexin-1

2

0

High-throughput

0.316

High

439134

MRM1
rRNA methyltransferase 1, mitochondrial

2

0

High-throughput

0.316

High

439147

JOS2
Josephin-2

2

0

High-throughput

0.316

High

439151

THAP4
Peroxynitrite isomerase THAP4

2

0

High-throughput

0.316

High

439158

RRFM
Ribosome-recycling factor, mitochondrial

2

0

High-throughput

0.316

High

439159

MTEF3
Transcription termination factor 3, mitochondrial

2

0

High-throughput

0.316

High

439164

WDFY2
WD repeat and FYVE domain-containing protein 2

2

0

High-throughput

0.316

High

439165

PNKP
Bifunctional polynucleotide phosphatase/kinase

2

0

High-throughput

0.316

High

439173

SMG9
Nonsense-mediated mRNA decay factor SMG9

2

0

High-throughput

0.316

High

439183

DBLOH
Diablo IAP-binding mitochondrial protein

2

0

High-throughput

0.316

High

439186

SPG21
Maspardin

2

0

High-throughput

0.316

High

439190

HSFX1
Heat shock transcription factor, X-linked

2

0

High-throughput

0.316

High

439192

PITC1
Cytoplasmic phosphatidylinositol transfer protein 1

2

0

High-throughput

0.316

High

439193

NDRG4
Protein NDRG4

2

0

High-throughput

0.316

High

439198

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

2

0

High-throughput

0.316

High

121408

HYAS3
Hyaluronan synthase 3

1

0

High-throughput

0.279

Low

197463

NDUS4
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

1

0

High-throughput

0.279

Low

212198

ERD23
ER lumen protein-retaining receptor 3

1

0

High-throughput

0.279

Low

282178

NCTR1
Natural cytotoxicity triggering receptor 1

1

0

High-throughput

0.279

Low

295706

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

0

High-throughput

0.279

Low

438666

SRPRA
Signal recognition particle receptor subunit alpha

1

0

High-throughput

0.279

Low

439100

AOFB
Amine oxidase [flavin-containing] B

1

0

High-throughput

0.279

Low

439103

S10A3
Protein S100-A3

1

0

High-throughput

0.279

Low

439104

FDFT
Squalene synthase

1

0

High-throughput

0.279

Low

439107

ETV3
ETS translocation variant 3

1

0

High-throughput

0.279

Low

439121

LBR
Delta(14)-sterol reductase LBR

1

0

High-throughput

0.279

Low

439122

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.279

Low

439123

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.279

Low

439127

ALG11
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

1

0

High-throughput

0.279

Low

439129

MTX3
Metaxin-3

1

0

High-throughput

0.279

Low

439130

SYRM
Probable arginine--tRNA ligase, mitochondrial

1

0

High-throughput

0.279

Low

439132

TM164
Transmembrane protein 164

1

0

High-throughput

0.279

Low

439133

ECM29
Proteasome adapter and scaffold protein ECM29

1

0

High-throughput

0.279

Low

439135

HPHL1
Ferroxidase HEPHL1

1

0

High-throughput

0.279

Low

439138

DHR13
Dehydrogenase/reductase SDR family member 13

1

0

High-throughput

0.279

Low

439140

DSG4
Desmoglein-4

1

0

High-throughput

0.279

Low

439145

MACOI
Macoilin

1

0

High-throughput

0.279

Low

439149

LRC15
Leucine-rich repeat-containing protein 15

1

0

High-throughput

0.279

Low

439152

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

1

0

High-throughput

0.279

Low

439155

TM186
Transmembrane protein 186

1

0

High-throughput

0.279

Low

439160

BSCL2
Seipin

1

0

High-throughput

0.279

Low

439161

ARL5B
ADP-ribosylation factor-like protein 5B

1

0

High-throughput

0.279

Low

439162

MBOA7
Lysophospholipid acyltransferase 7

1

0

High-throughput

0.279

Low

439167

PTSS2
Phosphatidylserine synthase 2

1

0

High-throughput

0.279

Low

439172

TSYL1
Testis-specific Y-encoded-like protein 1

1

0

High-throughput

0.279

Low

439175

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.279

Low

439177

S61A2
Protein transport protein Sec61 subunit alpha isoform 2

1

0

High-throughput

0.279

Low

439184

DJC11
DnaJ homolog subfamily C member 11

1

0

High-throughput

0.279

Low

439188

NDUF4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

1

0

High-throughput

0.279

Low

439189

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.279

Low

439195

TMCO1
Calcium load-activated calcium channel

1

0

High-throughput

0.279

Low

439196

SPG7
Mitochondrial inner membrane m-AAA protease component paraplegin

1

0

High-throughput

0.279

Low

439199

T184B
Transmembrane protein 184B

1

0

High-throughput

0.279

Low

439178

MYG1
MYG1 exonuclease

1

0

High-throughput

0.268

Low

439118

GAB1
GRB2-associated-binding protein 1

1

0

Small-scale

0.261

Low

100402

APRIO
Alternative prion protein

1

0

Small-scale

0.249

Low

118171

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.249

Low

439128

BOREA
Borealin

1

0

High-throughput

0.249

Low

439185

KTU
Protein kintoun

1

0

High-throughput

0.249

Low

439096

VSIG8
V-set and immunoglobulin domain-containing protein 8

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024