Protein: PRPS2
Ribose-phosphate pyrophosphokinase 2 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase II) (PRS-II)

Gene: PRPS2
Organism: Homo sapiens
Interactions: 236
UniProt ID: P11908

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0002189 - ribose phosphate diphosphokinase complex
GO:0004749 - ribose phosphate diphosphokinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

515827

PRPS1
Ribose-phosphate pyrophosphokinase 1

9

18

High-throughput

0.978

High

515854

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

7

17

Small-scale

0.969

High

225834

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

5

17

High-throughput

0.926

High

515792

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

17

High-throughput

0.740

High

515802

PRPS3
Ribose-phosphate pyrophosphokinase 3

1

18

High-throughput

0.691

High

236606

NMT2
Glycylpeptide N-tetradecanoyltransferase 2

3

2

High-throughput

0.667

High

455033

PARP1
Poly [ADP-ribose] polymerase 1

2

4

High-throughput

0.611

High

515798

NCK1
SH2/SH3 adapter protein NCK1

2

14

High-throughput

0.611

High

515914

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

2

2

High-throughput

0.611

High

515921

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.601

High

181782

SOCS1
Suppressor of cytokine signaling 1

2

14

High-throughput

0.571

High

235039

DOK2
Docking protein 2

2

4

High-throughput

0.571

High

261069

SH3L1
Adapter SH3BGRL

2

3

High-throughput

0.571

High

397131

KPCG
Protein kinase C gamma type

2

15

High-throughput

0.571

High

411967

FYN
Tyrosine-protein kinase Fyn

2

10

High-throughput

0.571

High

442769

HCK
Tyrosine-protein kinase HCK

2

10

High-throughput

0.571

High

454793

FGR
Tyrosine-protein kinase Fgr

2

10

High-throughput

0.571

High

515796

VAV
Proto-oncogene vav

2

3

High-throughput

0.571

High

515799

KPCA
Protein kinase C alpha type

2

10

High-throughput

0.571

High

515800

RAB5A
Ras-related protein Rab-5A

2

3

High-throughput

0.571

High

515801

RASA1
Ras GTPase-activating protein 1

2

3

High-throughput

0.571

High

515804

ELK4
ETS domain-containing protein Elk-4

2

5

High-throughput

0.571

High

515815

PAXI
Paxillin

2

4

High-throughput

0.571

High

515819

CAV2
Caveolin-2

2

7

High-throughput

0.571

High

515820

BMX
Cytoplasmic tyrosine-protein kinase BMX

2

11

High-throughput

0.571

High

515828

CDC42
Cell division control protein 42 homolog

2

8

High-throughput

0.571

High

515831

RAC1
Ras-related C3 botulinum toxin substrate 1

2

7

High-throughput

0.571

High

515835

KPCE
Protein kinase C epsilon type

2

10

High-throughput

0.571

High

515839

PTN12
Tyrosine-protein phosphatase non-receptor type 12

2

3

High-throughput

0.571

High

515850

PAK1
Serine/threonine-protein kinase PAK 1

2

4

High-throughput

0.571

High

515851

MK07
Mitogen-activated protein kinase 7

2

9

High-throughput

0.571

High

515860

KPCD1
Serine/threonine-protein kinase D1

2

14

High-throughput

0.571

High

515900

ABI1
Abl interactor 1

2

3

High-throughput

0.571

High

515903

SH2D3
SH2 domain-containing protein 3C

2

15

High-throughput

0.571

High

515972

GAB2
GRB2-associated-binding protein 2

2

4

High-throughput

0.571

High

515891

NT2NA
Notch homolog 2 N-terminal-like protein A

1

0

High-throughput

0.549

High

49918

ARH37
Rho guanine nucleotide exchange factor 37

1

4

High-throughput

0.536

High

127910

EMAL1
Echinoderm microtubule-associated protein-like 1

1

2

High-throughput

0.536

High

145970

SH2B2
SH2B adapter protein 2

1

15

High-throughput

0.536

High

165618

SET1A
Histone-lysine N-methyltransferase SETD1A

1

2

High-throughput

0.536

High

199034

PAPS1
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

1

1

High-throughput

0.536

High

232774

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

4

High-throughput

0.536

High

253308

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

3

High-throughput

0.536

High

269516

SKAP2
Src kinase-associated phosphoprotein 2

1

11

High-throughput

0.536

High

309434

MTMR5
Myotubularin-related protein 5

1

1

High-throughput

0.536

High

311407

PAPS2
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2

1

1

High-throughput

0.536

High

311466

SMC2
Structural maintenance of chromosomes protein 2

1

1

High-throughput

0.536

High

456253

IFIT1
Interferon-induced protein with tetratricopeptide repeats 1

1

2

High-throughput

0.536

High

508305

TOP1
DNA topoisomerase 1

1

2

High-throughput

0.536

High

515807

NMT1
Glycylpeptide N-tetradecanoyltransferase 1

1

2

High-throughput

0.536

High

515808

KINH
Kinesin-1 heavy chain

1

3

High-throughput

0.536

High

515813

CAPZB
F-actin-capping protein subunit beta

1

2

High-throughput

0.536

High

515841

KLC1
Kinesin light chain 1

1

3

High-throughput

0.536

High

515844

DMWD
Dystrophia myotonica WD repeat-containing protein

1

1

High-throughput

0.536

High

515845

KIF1A
Kinesin-like protein KIF1A

1

4

High-throughput

0.536

High

515846

ARHG5
Rho guanine nucleotide exchange factor 5

1

4

High-throughput

0.536

High

515849

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

4

High-throughput

0.536

High

515853

PEX6
Peroxisomal ATPase PEX6

1

2

High-throughput

0.536

High

515864

ELF2
ETS-related transcription factor Elf-2

1

5

High-throughput

0.536

High

515868

INAVA
Innate immunity activator protein

1

1

High-throughput

0.536

High

515874

MRCKA
Serine/threonine-protein kinase MRCK alpha

1

1

High-throughput

0.536

High

515883

PKN3
Serine/threonine-protein kinase N3

1

11

High-throughput

0.536

High

515885

DUSTY
Dual serine/threonine and tyrosine protein kinase

1

4

High-throughput

0.536

High

515890

POGZ
Pogo transposable element with ZNF domain

1

2

High-throughput

0.536

High

515893

SRGP1
SLIT-ROBO Rho GTPase-activating protein 1

1

3

High-throughput

0.536

High

515894

KAISO
Transcriptional regulator Kaiso

1

3

High-throughput

0.536

High

515904

CE112
Centrosomal protein of 112 kDa

1

1

High-throughput

0.536

High

515908

NEDD1
Protein NEDD1

1

1

High-throughput

0.536

High

515916

TAF4B
Transcription initiation factor TFIID subunit 4B

1

1

High-throughput

0.536

High

515919

DDX11
ATP-dependent DNA helicase DDX11

1

2

High-throughput

0.536

High

515924

ASPP1
Apoptosis-stimulating of p53 protein 1

1

2

High-throughput

0.536

High

515926

NEK1
Serine/threonine-protein kinase Nek1

1

4

High-throughput

0.536

High

515927

CK5P2
CDK5 regulatory subunit-associated protein 2

1

2

High-throughput

0.536

High

515932

AFG2B
ATPase family gene 2 protein homolog B

1

2

High-throughput

0.536

High

515933

FANCJ
Fanconi anemia group J protein

1

2

High-throughput

0.536

High

515934

EIF2A
Eukaryotic translation initiation factor 2A

1

1

High-throughput

0.536

High

515936

TRIM7
E3 ubiquitin-protein ligase TRIM7

1

1

High-throughput

0.536

High

515938

KLC2
Kinesin light chain 2

1

3

High-throughput

0.536

High

515943

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

3

High-throughput

0.536

High

515947

ELP3
Elongator complex protein 3

1

1

High-throughput

0.536

High

515949

EMAL4
Echinoderm microtubule-associated protein-like 4

1

2

High-throughput

0.536

High

515950

BRMS1
Breast cancer metastasis-suppressor 1

1

1

High-throughput

0.536

High

515956

KLC4
Kinesin light chain 4

1

3

High-throughput

0.536

High

515957

PDS5B
Sister chromatid cohesion protein PDS5 homolog B

1

3

High-throughput

0.536

High

515960

RTEL1
Regulator of telomere elongation helicase 1

1

2

High-throughput

0.536

High

515962

GMIP
GEM-interacting protein

1

2

High-throughput

0.536

High

515964

DIP2B
Disco-interacting protein 2 homolog B

1

2

High-throughput

0.536

High

515965

E2AK4
eIF-2-alpha kinase GCN2

1

1

High-throughput

0.536

High

515971

TBD2B
TBC1 domain family member 2B

1

5

High-throughput

0.536

High

515976

HBS1L
HBS1-like protein

1

1

High-throughput

0.536

High

515837

CAV1
Caveolin-1

2

7

High-throughput

0.521

High

231440

KIF1B
Kinesin-like protein KIF1B

1

4

High-throughput

0.515

High

388187

HSPB1
Heat shock protein beta-1

1

2

High-throughput

0.515

High

62869

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

0

High-throughput

0.513

High

155983

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

0

High-throughput

0.513

High

157824

IRF6
Interferon regulatory factor 6

1

0

High-throughput

0.513

High

215516

CF410
Cilia- and flagella-associated protein 410

1

0

High-throughput

0.513

High

224283

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.513

High

256876

NPHP4
Nephrocystin-4

1

0

High-throughput

0.513

High

295583

RMP
Unconventional prefoldin RPB5 interactor 1

1

0

High-throughput

0.513

High

300877

HAUS5
HAUS augmin-like complex subunit 5

1

0

High-throughput

0.513

High

305125

ARK73
Aflatoxin B1 aldehyde reductase member 3

1

0

High-throughput

0.513

High

317205

PCNT
Pericentrin

1

0

High-throughput

0.513

High

330226

BCL10
B-cell lymphoma/leukemia 10

1

0

High-throughput

0.513

High

471553

TFPT
TCF3 fusion partner

1

0

High-throughput

0.513

High

515795

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.513

High

515805

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.513

High

515809

GLYC
Serine hydroxymethyltransferase, cytosolic

1

0

High-throughput

0.513

High

515812

EIF2D
Eukaryotic translation initiation factor 2D

1

0

High-throughput

0.513

High

515817

PRI1
DNA primase small subunit

1

0

High-throughput

0.513

High

515822

PMS1
PMS1 protein homolog 1

1

0

High-throughput

0.513

High

515834

AMPD2
AMP deaminase 2

1

0

High-throughput

0.513

High

515847

TROAP
Tastin

1

0

High-throughput

0.513

High

515862

CYH1
Cytohesin-1

1

0

High-throughput

0.513

High

515866

KIZ
Centrosomal protein kizuna

1

0

High-throughput

0.513

High

515876

ICE2
Little elongation complex subunit 2

1

0

High-throughput

0.513

High

515887

CRACD
Capping protein-inhibiting regulator of actin dynamics

1

0

High-throughput

0.513

High

515888

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.513

High

515897

SKA3
Spindle and kinetochore-associated protein 3

1

0

High-throughput

0.513

High

515905

SMG8
Nonsense-mediated mRNA decay factor SMG8

1

0

High-throughput

0.513

High

515906

CBPC5
Cytosolic carboxypeptidase-like protein 5

1

0

High-throughput

0.513

High

515907

BBS1
Bardet-Biedl syndrome 1 protein

1

0

High-throughput

0.513

High

515910

CABL1
CDK5 and ABL1 enzyme substrate 1

1

0

High-throughput

0.513

High

515913

TRUB1
Pseudouridylate synthase TRUB1

1

0

High-throughput

0.513

High

515918

SYAP1
Synapse-associated protein 1

1

0

High-throughput

0.513

High

515920

CEP95
Centrosomal protein of 95 kDa

1

0

High-throughput

0.513

High

515923

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

0

High-throughput

0.513

High

515929

METH
Methionine synthase

1

0

High-throughput

0.513

High

515930

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

1

0

High-throughput

0.513

High

515931

PKP2
Plakophilin-2

1

0

High-throughput

0.513

High

515935

DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

1

0

High-throughput

0.513

High

515940

FA83D
Protein FAM83D

1

0

High-throughput

0.513

High

515944

YYAP1
YY1-associated protein 1

1

0

High-throughput

0.513

High

515945

CSR2B
Cysteine-rich protein 2-binding protein

1

0

High-throughput

0.513

High

515954

ACSA
Acetyl-coenzyme A synthetase, cytoplasmic

1

0

High-throughput

0.513

High

515955

SMYD2
N-lysine methyltransferase SMYD2

1

0

High-throughput

0.513

High

515959

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

0

High-throughput

0.513

High

515961

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

0

High-throughput

0.513

High

515963

CAMP3
Calmodulin-regulated spectrin-associated protein 3

1

0

High-throughput

0.513

High

515969

FBX10
F-box only protein 10

1

0

High-throughput

0.513

High

515973

UTP11
Probable U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.513

High

515975

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.513

High

475287

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.501

High

515811

T2FA
General transcription factor IIF subunit 1

1

1

High-throughput

0.489

High

515842

FOXM1
Forkhead box protein M1

1

1

High-throughput

0.489

High

515855

I5P1
Inositol polyphosphate-5-phosphatase A

1

1

High-throughput

0.489

High

515856

DIP2A
Disco-interacting protein 2 homolog A

1

2

High-throughput

0.489

High

515865

CART

1

1

High-throughput

0.489

High

515878

Z518A
Zinc finger protein 518A

1

1

High-throughput

0.489

High

515879

ADNP2
Activity-dependent neuroprotector homeobox protein 2

1

3

High-throughput

0.489

High

515882

NFRKB
Nuclear factor related to kappa-B-binding protein

1

1

High-throughput

0.489

High

515896

MGAP
MAX gene-associated protein

1

1

High-throughput

0.489

High

515898

ASXL1
Polycomb group protein ASXL1

1

1

High-throughput

0.489

High

515922

CC120
Coiled-coil domain-containing protein 120

1

1

High-throughput

0.489

High

515946

WDR76
WD repeat-containing protein 76

1

4

High-throughput

0.489

High

515952

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

1

High-throughput

0.489

High

515968

TASOR
Protein TASOR

1

1

High-throughput

0.489

High

213471

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

1

High-throughput

0.479

High

515793

TCTP
Translationally-controlled tumor protein

1

1

High-throughput

0.479

High

515814

TISD
mRNA decay activator protein ZFP36L2

1

3

High-throughput

0.479

High

515821

ATX1
Ataxin-1

1

3

High-throughput

0.479

High

515823

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

2

High-throughput

0.479

High

515824

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

4

High-throughput

0.479

High

515826

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.479

High

515829

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

515830

1433E
14-3-3 protein epsilon

1

3

Small-scale

0.479

High

515836

KIF23
Kinesin-like protein KIF23

1

3

High-throughput

0.479

High

515838

UBXN1
UBX domain-containing protein 1

1

3

High-throughput

0.479

High

515840

GFPT1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

1

1

High-throughput

0.479

High

515852

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

9

High-throughput

0.479

High

515857

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.479

High

515858

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.479

High

515859

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.479

High

515867

TECT1
Tectonic-1

1

1

High-throughput

0.479

High

515886

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

515917

KAT6A
Histone acetyltransferase KAT6A

1

1

High-throughput

0.479

High

515928

CRBN
Protein cereblon

1

1

Small-scale

0.479

High

515941

PKHA4
Pleckstrin homology domain-containing family A member 4

1

12

High-throughput

0.479

High

515942

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

2

High-throughput

0.479

High

515948

NMRL1
NmrA-like family domain-containing protein 1

1

1

High-throughput

0.479

High

515967

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

281519

WFS1
Wolframin

1

1

High-throughput

0.470

High

233176

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

324197

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

515825

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

High-throughput

0.458

High

515833

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

515909

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.458

High

515925

SNX27
Sorting nexin-27

1

0

High-throughput

0.458

High

515951

MYO10
Unconventional myosin-X

1

0

Small-scale

0.458

High

515953

ANLN
Anillin

1

0

High-throughput

0.458

High

515966

HDAC6
Histone deacetylase 6

1

0

High-throughput

0.458

High

515797

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

515803

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

515810

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

515816

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

515870

EMC4
ER membrane protein complex subunit 4

1

3

High-throughput

0.437

High

515875

OTUD1
OTU domain-containing protein 1

1

1

High-throughput

0.437

High

515937

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.437

High

515978

CSAG2
Chondrosarcoma-associated gene 2/3 protein

1

1

High-throughput

0.407

High

515818

PRI2
DNA primase large subunit

3

0

High-throughput

0.347

High

63723

CC85C
Coiled-coil domain-containing protein 85C

1

0

High-throughput

0.279

Low

132004

VMA5A
von Willebrand factor A domain-containing protein 5A

1

0

High-throughput

0.279

Low

362752

FINC
Fibronectin

1

0

High-throughput

0.279

Low

403549

DQB2
HLA class II histocompatibility antigen, DQ beta 2 chain

1

0

High-throughput

0.279

Low

515794

T2FB
General transcription factor IIF subunit 2

1

0

High-throughput

0.279

Low

515832

EM55
55 kDa erythrocyte membrane protein

1

0

High-throughput

0.279

Low

515843

GOGA2
Golgin subfamily A member 2

1

0

High-throughput

0.279

Low

515848

SF3A3
Splicing factor 3A subunit 3

1

0

High-throughput

0.279

Low

515861

SF3A2
Splicing factor 3A subunit 2

1

0

High-throughput

0.279

Low

515863

SF3A1
Splicing factor 3A subunit 1

1

0

High-throughput

0.279

Low

515869

EPC2
Enhancer of polycomb homolog 2

1

0

High-throughput

0.279

Low

515871

SNPC4
snRNA-activating protein complex subunit 4

1

0

High-throughput

0.279

Low

515872

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.279

Low

515873

LIN9
Protein lin-9 homolog

1

0

High-throughput

0.279

Low

515877

C19L1
CWF19-like protein 1

1

0

High-throughput

0.279

Low

515880

LIN54
Protein lin-54 homolog

1

0

High-throughput

0.279

Low

515881

M18BP
Mis18-binding protein 1

1

0

High-throughput

0.279

Low

515884

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

0

High-throughput

0.279

Low

515892

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

0

High-throughput

0.279

Low

515895

P66A
Transcriptional repressor p66-alpha

1

0

High-throughput

0.279

Low

515899

ZZZ3
ZZ-type zinc finger-containing protein 3

1

0

High-throughput

0.279

Low

515901

PUSL1
tRNA pseudouridine synthase-like 1

1

0

High-throughput

0.279

Low

515902

HROB
Homologous recombination OB-fold protein

1

0

High-throughput

0.279

Low

515911

TF3C2
General transcription factor 3C polypeptide 2

1

0

High-throughput

0.279

Low

515912

F216A
Protein FAM216A

1

0

High-throughput

0.279

Low

515915

ZN592
Zinc finger protein 592

1

0

High-throughput

0.279

Low

515939

PUS7L
Pseudouridylate synthase PUS7L

1

0

High-throughput

0.279

Low

515958

BCD1
Box C/D snoRNA protein 1

1

0

High-throughput

0.279

Low

515970

YETS2
YEATS domain-containing protein 2

1

0

High-throughput

0.279

Low

515977

SALL2
Sal-like protein 2

1

0

High-throughput

0.279

Low

515979

TF3C5
General transcription factor 3C polypeptide 5

1

0

High-throughput

0.279

Low

363558

TTHY
Transthyretin

1

0

High-throughput

0.268

Low

515806

GRN
Progranulin

1

0

High-throughput

0.268

Low

515974

RNF11
RING finger protein 11

1

0

High-throughput

0.268

Low

515889

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024