Protein: SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC 1.3.5.1) (Iron-sulfur subunit of complex II) (Ip)

Gene: SDHB
Organism: Homo sapiens
Interactions: 133
UniProt ID: P21912

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

602071

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

7

6

Small-scale

0.958

High

62625

SDHF1
Succinate dehydrogenase assembly factor 1, mitochondrial

3

1

Small-scale

0.683

High

146903

DHSD
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

1

0

High-throughput

0.656

High

602119

HSC20
Iron-sulfur cluster co-chaperone protein HscB

3

0

Small-scale

0.651

High

602116

ACD11
Acyl-CoA dehydrogenase family member 11

2

1

High-throughput

0.628

High

602122

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

2

2

High-throughput

0.621

High

602141

C560
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

1

1

High-throughput

0.618

High

602107

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

3

0

Small-scale

0.613

High

602097

CUL3
Cullin-3

2

2

High-throughput

0.611

High

602155

SDHF3
Succinate dehydrogenase assembly factor 3, mitochondrial

3

1

High-throughput

0.609

High

602079

SYHM
Histidine--tRNA ligase, mitochondrial

2

0

High-throughput

0.602

High

602081

DPOG1
DNA polymerase subunit gamma-1

2

0

High-throughput

0.602

High

602093

TOP3A
DNA topoisomerase 3-alpha

2

0

High-throughput

0.602

High

602108

ACSF3
Malonate--CoA ligase ACSF3, mitochondrial

2

0

High-throughput

0.602

High

282028

CLPX
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial

2

0

Small-scale

0.585

High

602148

ISCU
Iron-sulfur cluster assembly enzyme ISCU

2

0

Small-scale

0.576

High

602072

GRP75
Stress-70 protein, mitochondrial

2

5

Small-scale

0.570

High

262705

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.559

High

602137

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

147881

ACPM
Acyl carrier protein, mitochondrial

1

1

High-throughput

0.536

High

602095

CUL1
Cullin-1

1

2

High-throughput

0.536

High

602096

CUL2
Cullin-2

1

2

High-throughput

0.536

High

602090

TP53B
TP53-binding protein 1

1

0

High-throughput

0.529

High

571083

EGLN
Endoglin

1

0

High-throughput

0.513

High

602101

SYLM
Leucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

602102

P2RY6
P2Y purinoceptor 6

1

0

High-throughput

0.513

High

602104

MYLK
Myosin light chain kinase, smooth muscle

1

0

High-throughput

0.513

High

602118

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

602123

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.513

High

602126

PDPR
Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial

1

0

High-throughput

0.513

High

602131

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

602135

RTP4
Receptor-transporting protein 4

1

0

High-throughput

0.513

High

602145

TX101
Testis-expressed protein 101

1

0

High-throughput

0.513

High

602149

MMAD
Cobalamin trafficking protein CblD

1

0

High-throughput

0.513

High

602153

RSAD1
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial

1

0

High-throughput

0.513

High

602156

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

0

High-throughput

0.513

High

602161

NPS3A
Protein NipSnap homolog 3A

1

0

High-throughput

0.513

High

153082

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

1

High-throughput

0.489

High

208092

SPY2
Protein sprouty homolog 2

1

0

High-throughput

0.486

High

602083

GEM
GTP-binding protein GEM

1

0

High-throughput

0.486

High

602130

PI3R5
Phosphoinositide 3-kinase regulatory subunit 5

1

0

High-throughput

0.486

High

196264

PJA2
E3 ubiquitin-protein ligase Praja-2

1

1

Small-scale

0.479

High

226517

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

258404

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

1

High-throughput

0.479

High

345922

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

379013

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

499525

CH60
60 kDa heat shock protein, mitochondrial

1

6

High-throughput

0.479

High

602073

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

602085

ABCE1
ATP-binding cassette sub-family E member 1

1

1

High-throughput

0.479

High

602106

FRDA
Frataxin, mitochondrial

1

1

Small-scale

0.479

High

602120

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

602152

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

1

High-throughput

0.479

High

315237

ABCA1
Phospholipid-transporting ATPase ABCA1

1

0

Small-scale

0.460

High

602121

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.460

High

602164

MSRA
Mitochondrial peptide methionine sulfoxide reductase

1

0

Small-scale

0.460

High

56505

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

1

0

High-throughput

0.458

High

130436

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.458

High

148394

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

182551

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

205040

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

262371

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

294361

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

327355

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

353379

PIGR
Polymeric immunoglobulin receptor

1

0

Small-scale

0.458

High

440338

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

530422

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

569181

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

602070

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.458

High

602076

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

602077

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

602078

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

602080

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.458

High

602082

ATX3
Ataxin-3

1

0

Small-scale

0.458

High

602084

HDAC4
Histone deacetylase 4

1

0

High-throughput

0.458

High

602087

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

602088

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

602092

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

602094

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

602098

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

602099

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.458

High

602103

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

602111

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

602113

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

602114

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

602127

MCU
Calcium uniporter protein, mitochondrial

1

0

High-throughput

0.458

High

602128

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

602132

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.458

High

602134

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.458

High

602136

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

0

High-throughput

0.458

High

602139

EFGM
Elongation factor G, mitochondrial

1

0

High-throughput

0.458

High

602140

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.458

High

602143

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

602144

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

602150

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

602151

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

602159

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

602160

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

602162

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

602165

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.458

High

602166

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.458

High

602168

DJC15
DnaJ homolog subfamily C member 15

1

0

High-throughput

0.458

High

602105

CART

1

1

Small-scale

0.457

High

305962

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

1

High-throughput

0.445

High

397270

ADT2
ADP/ATP translocase 2

1

1

Small-scale

0.445

High

401415

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

416351

S10A9
Protein S100-A9

1

0

Small-scale

0.438

High

602142

GFI1
Zinc finger protein Gfi-1

1

0

Small-scale

0.438

High

602154

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

496298

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

581422

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.426

High

602075

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.426

High

602112

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

602147

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

1

High-throughput

0.407

High

602109

PPCEL
Prolyl endopeptidase-like

2

0

High-throughput

0.328

High

602074

CCNF
Cyclin-F

2

0

High-throughput

0.305

High

313970

PPN
Papilin

1

0

High-throughput

0.279

Low

602117

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

602129

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.279

Low

602133

RAB7B
Ras-related protein Rab-7b

1

0

High-throughput

0.279

Low

602146

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.279

Low

602100

T132D
Transmembrane protein 132D

1

0

Small-scale

0.251

Low

602086

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

602089

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

0

High-throughput

0.249

Low

602091

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.249

Low

602110

MIDN
Midnolin

1

0

High-throughput

0.249

Low

602115

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

602124

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

602125

MTMRE
Myotubularin-related protein 14

1

0

High-throughput

0.249

Low

602138

UBX10
UBX domain-containing protein 10

1

0

High-throughput

0.249

Low

602157

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

602158

OCAD1
OCIA domain-containing protein 1

1

0

Small-scale

0.249

Low

602163

DS13B
Dual specificity protein phosphatase 13B

1

0

High-throughput

0.249

Low

602167

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024