Protein: PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PIMT) (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl/D-aspartyl methyltransferase) (Protein-beta-aspartate methyltransferase)

Gene: PIMT, PCMT1
Organism: Homo sapiens
Interactions: 228
UniProt ID: P22061

Gene Ontology (top 5):
GO:0004719 - protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006479 - protein methylation
GO:0030091 - protein repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

603128

RPIA
Ribose-5-phosphate isomerase

6

0

High-throughput

0.707

High

603189

KLH24
Kelch-like protein 24

3

3

High-throughput

0.667

High

603197

KBTB6
Kelch repeat and BTB domain-containing protein 6

3

5

High-throughput

0.667

High

603213

KBTB7
Kelch repeat and BTB domain-containing protein 7

3

4

High-throughput

0.667

High

603253

ABI2
Abl interactor 2

3

3

High-throughput

0.667

High

603254

KLH42
Kelch-like protein 42

3

4

High-throughput

0.667

High

528545

CFTR
Cystic fibrosis transmembrane conductance regulator

4

0

High-throughput

0.661

High

345925

MYC
Myc proto-oncogene protein

3

1

High-throughput

0.640

High

603157

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

3

0

Small-scale

0.640

High

603107

KTHY
Thymidylate kinase

3

0

High-throughput

0.638

High

603130

KC1E
Casein kinase I isoform epsilon

3

0

High-throughput

0.638

High

603180

P5CR3
Pyrroline-5-carboxylate reductase 3

3

0

High-throughput

0.638

High

603205

PDPR
Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial

3

0

High-throughput

0.638

High

603224

RAB3I
Rab-3A-interacting protein

3

0

High-throughput

0.638

High

603246

MA2C1
Alpha-mannosidase 2C1

3

0

High-throughput

0.638

High

603268

DEOC
Deoxyribose-phosphate aldolase

3

0

High-throughput

0.638

High

603135

ATX1
Ataxin-1

2

1

High-throughput

0.621

High

603202

ABI1
Abl interactor 1

2

2

High-throughput

0.611

High

603266

KLH20
Kelch-like protein 20

2

3

High-throughput

0.611

High

299507

KLH18
Kelch-like protein 18

3

3

High-throughput

0.609

High

603209

SHKB1
SH3KBP1-binding protein 1

3

1

High-throughput

0.609

High

603271

KCTD3
BTB/POZ domain-containing protein KCTD3

3

1

High-throughput

0.609

High

359660

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

3

0

High-throughput

0.606

High

603169

IQCB1
IQ calmodulin-binding motif-containing protein 1

2

2

High-throughput

0.606

High

603242

CSN7B
COP9 signalosome complex subunit 7b

2

0

High-throughput

0.602

High

603103

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

0

High-throughput

0.586

High

603219

CSN5
COP9 signalosome complex subunit 5

2

0

High-throughput

0.585

High

226520

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.584

High

475335

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

3

Small-scale

0.584

High

603126

YAP1
Transcriptional coactivator YAP1

2

1

High-throughput

0.584

High

603215

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

2

3

Small-scale

0.584

High

603256

HDAC6
Histone deacetylase 6

2

3

Small-scale

0.584

High

603220

CLP1
Polyribonucleotide 5'-hydroxyl-kinase Clp1

2

0

High-throughput

0.580

High

603138

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

2

2

High-throughput

0.571

High

603171

EEA1
Early endosome antigen 1

2

2

High-throughput

0.571

High

603175

RHGBB
Inactive Rho GTPase-activating protein 11B

2

1

High-throughput

0.571

High

603214

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

2

0

Small-scale

0.559

High

581424

VCAM1
Vascular cell adhesion protein 1

2

0

High-throughput

0.547

High

592099

RAB5A
Ras-related protein Rab-5A

2

0

High-throughput

0.547

High

603206

DOCK8
Dedicator of cytokinesis protein 8

2

0

High-throughput

0.547

High

603124

CCR2
C-C chemokine receptor type 2

1

1

High-throughput

0.541

High

603160

CUL1
Cullin-1

1

5

High-throughput

0.536

High

603161

CUL2
Cullin-2

1

5

High-throughput

0.536

High

603162

CUL3
Cullin-3

1

5

High-throughput

0.536

High

603227

ZBT18
Zinc finger and BTB domain-containing protein 18

2

1

Small-scale

0.521

High

603143

DLG4
Disks large homolog 4

1

0

High-throughput

0.518

High

603154

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

0

High-throughput

0.518

High

603121

VHL
von Hippel-Lindau disease tumor suppressor

1

1

High-throughput

0.515

High

603194

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

1

High-throughput

0.515

High

128439

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.513

High

336361

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

603118

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.513

High

603188

KLC3
Kinesin light chain 3

1

0

High-throughput

0.513

High

603198

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

603229

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.513

High

603114

AGTR1
Type-1 angiotensin II receptor

1

1

High-throughput

0.494

High

603225

TAAR1
Trace amine-associated receptor 1

1

1

High-throughput

0.494

High

603245

CLTR2
Cysteinyl leukotriene receptor 2

1

2

High-throughput

0.494

High

603111

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.493

High

603122

CCNF
Cyclin-F

1

0

High-throughput

0.493

High

157865

KLF11
Krueppel-like factor 11

1

0

High-throughput

0.493

High

603139

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.493

High

603218

APBB2
Amyloid beta precursor protein binding family B member 2

1

0

High-throughput

0.493

High

361443

APOE
Apolipoprotein E

1

1

High-throughput

0.481

High

56506

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

1

2

High-throughput

0.479

High

148395

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.479

High

160380

AURKA
Aurora kinase A

1

1

High-throughput

0.479

High

204611

E41L2
Band 4.1-like protein 2

1

1

High-throughput

0.479

High

209669

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

301613

TRI37
E3 ubiquitin-protein ligase TRIM37

1

2

High-throughput

0.479

High

362814

FINC
Fibronectin

1

1

High-throughput

0.479

High

505548

EPB41
Protein 4.1

1

1

High-throughput

0.479

High

569182

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

573571

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

2

High-throughput

0.479

High

603105

PTPRE
Receptor-type tyrosine-protein phosphatase epsilon

1

2

High-throughput

0.479

High

603119

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

603120

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.479

High

603123

HNF4A
Hepatocyte nuclear factor 4-alpha

1

2

High-throughput

0.479

High

603136

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.479

High

603141

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

603145

RELB
Transcription factor RelB

1

1

High-throughput

0.479

High

603146

PO5F1
POU domain, class 5, transcription factor 1

1

1

High-throughput

0.479

High

603147

KIF23
Kinesin-like protein KIF23

1

5

High-throughput

0.479

High

603151

AKP13
A-kinase anchor protein 13

1

1

High-throughput

0.479

High

603153

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

3

High-throughput

0.479

High

603163

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

3

High-throughput

0.479

High

603167

TNIP1
TNFAIP3-interacting protein 1

1

5

High-throughput

0.479

High

603170

KIF14
Kinesin-like protein KIF14

1

3

High-throughput

0.479

High

603176

LARP7
La-related protein 7

1

1

High-throughput

0.479

High

603179

RHG29
Rho GTPase-activating protein 29

1

1

High-throughput

0.479

High

603184

RN123
E3 ubiquitin-protein ligase RNF123

1

2

High-throughput

0.479

High

603200

SLX4
Structure-specific endonuclease subunit SLX4

1

1

High-throughput

0.479

High

603203

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.479

High

603210

BICD2
Protein bicaudal D homolog 2

1

2

High-throughput

0.479

High

603211

SSH3
Protein phosphatase Slingshot homolog 3

1

1

High-throughput

0.479

High

603217

RBP56
TATA-binding protein-associated factor 2N

1

1

High-throughput

0.479

High

603226

RUFY1
RUN and FYVE domain-containing protein 1

1

1

High-throughput

0.479

High

603236

WWTR1
WW domain-containing transcription regulator protein 1

1

1

High-throughput

0.479

High

603240

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

603241

RNF41
E3 ubiquitin-protein ligase NRDP1

1

3

Small-scale

0.479

High

603244

ARGAL
Rho guanine nucleotide exchange factor 10-like protein

1

1

High-throughput

0.479

High

603260

DS13B
Dual specificity protein phosphatase 13B

1

1

High-throughput

0.479

High

603262

TNIK
TRAF2 and NCK-interacting protein kinase

1

2

High-throughput

0.479

High

603264

HDAC5
Histone deacetylase 5

1

3

High-throughput

0.479

High

603269

TRAF6
TNF receptor-associated factor 6

1

3

High-throughput

0.479

High

603270

M4K5
Mitogen-activated protein kinase kinase kinase kinase 5

1

2

High-throughput

0.479

High

103701

G5E9A7
DM1 locus, WD repeat containing

1

2

High-throughput

0.470

High

231452

KIF1B
Kinesin-like protein KIF1B

1

2

High-throughput

0.470

High

201755

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

0

High-throughput

0.458

High

255503

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

277934

PIAS1
E3 SUMO-protein ligase PIAS1

1

0

High-throughput

0.458

High

294362

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

298150

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

302899

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

322181

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

326435

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

354289

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

381798

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.458

High

386091

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

503431

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

521722

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

530423

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

547438

FOLR1
Folate receptor alpha

1

0

High-throughput

0.458

High

603106

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.458

High

603108

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

603109

TNR5
Tumor necrosis factor receptor superfamily member 5

1

0

High-throughput

0.458

High

603110

PAX6
Paired box protein Pax-6

1

0

High-throughput

0.458

High

603127

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

603129

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.458

High

603132

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

603133

PPT1
Palmitoyl-protein thioesterase 1

1

0

High-throughput

0.458

High

603134

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

603137

RAB25
Ras-related protein Rab-25

1

0

High-throughput

0.458

High

603140

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

603150

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.458

High

603155

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

603156

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.458

High

603158

PAK2
Serine/threonine-protein kinase PAK 2

1

0

High-throughput

0.458

High

603159

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

603165

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.458

High

603166

CUL7
Cullin-7

1

0

High-throughput

0.458

High

603168

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

603173

ITSN1
Intersectin-1

1

0

High-throughput

0.458

High

603178

MIDN
Midnolin

1

0

High-throughput

0.458

High

603182

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.458

High

603185

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

603191

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

603192

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.458

High

603195

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

603196

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

603199

GPBP1
Vasculin

1

0

High-throughput

0.458

High

603207

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.458

High

603208

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.458

High

603223

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

603230

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

603231

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

603234

TRI31
E3 ubiquitin-protein ligase TRIM31

1

0

High-throughput

0.458

High

603237

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

603238

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

603251

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

603257

TRMB
tRNA

1

0

High-throughput

0.458

High

603258

KS6B2
Ribosomal protein S6 kinase beta-2

1

0

High-throughput

0.458

High

603259

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

603261

GGA1
ADP-ribosylation factor-binding protein GGA1

1

0

High-throughput

0.458

High

603265

FBW1A
F-box/WD repeat-containing protein 1A

1

0

High-throughput

0.458

High

361316

APOA1
Apolipoprotein A-I

1

1

High-throughput

0.457

High

587413

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

1

High-throughput

0.445

High

603104

PTPRB
Receptor-type tyrosine-protein phosphatase beta

1

2

High-throughput

0.445

High

603115

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.445

High

603142

GRB2
Growth factor receptor-bound protein 2

1

1

High-throughput

0.445

High

603235

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

2

High-throughput

0.445

High

603239

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

2

High-throughput

0.445

High

517050

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.438

High

308404

KI20A
Kinesin-like protein KIF20A

1

5

High-throughput

0.437

High

379014

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.437

High

603117

HNF1B
Hepatocyte nuclear factor 1-beta

1

1

High-throughput

0.437

High

603125

MATR3
Matrin-3

1

2

High-throughput

0.437

High

603172

TERF2
Telomeric repeat-binding factor 2

1

1

High-throughput

0.437

High

603174

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.437

High

603181

KLH26
Kelch-like protein 26

1

3

High-throughput

0.437

High

603193

DPPA4
Developmental pluripotency-associated protein 4

1

1

High-throughput

0.437

High

603212

SH3R2
E3 ubiquitin-protein ligase SH3RF2

1

1

Small-scale

0.437

High

603216

ESR2
Estrogen receptor beta

1

2

High-throughput

0.437

High

603233

PCGF1
Polycomb group RING finger protein 1

1

3

High-throughput

0.437

High

603243

NANOG
Homeobox protein NANOG

1

3

High-throughput

0.437

High

603249

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

4

High-throughput

0.437

High

603250

SLTM
SAFB-like transcription modulator

1

1

High-throughput

0.437

High

603255

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

1

Small-scale

0.437

High

371359

ANGI
Angiogenin

1

0

High-throughput

0.426

High

496299

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

603144

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.426

High

401416

JUN
Transcription factor Jun

1

3

High-throughput

0.407

High

603131

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.373

High

66885

YDJC
Carbohydrate deacetylase

3

0

High-throughput

0.347

High

603201

A16A1
Aldehyde dehydrogenase family 16 member A1

3

0

High-throughput

0.347

High

603204

TM102
Transmembrane protein 102

3

0

High-throughput

0.347

High

603222

RMC1
Regulator of MON1-CCZ1 complex

3

0

High-throughput

0.347

High

452622

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

239492

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.269

Low

281544

WFS1
Wolframin

1

0

High-throughput

0.268

Low

603113

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

0

High-throughput

0.268

Low

603221

COQA1
Collagen alpha-1(XXVI) chain

1

0

High-throughput

0.268

Low

603232

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

0

Small-scale

0.251

Low

168235

DEGS1
Sphingolipid delta(4)-desaturase DES1

1

0

High-throughput

0.249

Low

243930

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.249

Low

329356

AGR2
Anterior gradient protein 2 homolog

1

0

Small-scale

0.249

Low

384260

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

545936

MYOD1
Myoblast determination protein 1

1

0

High-throughput

0.249

Low

551943

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

554801

TIMP2
Metalloproteinase inhibitor 2

1

0

High-throughput

0.249

Low

603112

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

603116

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

603148

HEN1
Helix-loop-helix protein 1

1

0

High-throughput

0.249

Low

603149

HME1
Homeobox protein engrailed-1

1

0

High-throughput

0.249

Low

603164

NFYC
Nuclear transcription factor Y subunit gamma

1

0

High-throughput

0.249

Low

603177

FBX43
F-box only protein 43

1

0

Small-scale

0.249

Low

603183

RC3H1
Roquin-1

1

0

High-throughput

0.249

Low

603186

TET2
Methylcytosine dioxygenase TET2

1

0

Small-scale

0.249

Low

603187

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.249

Low

603190

BCOR
BCL-6 corepressor

1

0

High-throughput

0.249

Low

603228

CTIP
DNA endonuclease RBBP8

1

0

Small-scale

0.249

Low

603247

T106B
Transmembrane protein 106B

1

0

High-throughput

0.249

Low

603248

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.249

Low

603252

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

603263

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

603267

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

603152

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024