Protein: HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1 (Cardiovascular helix-loop-helix factor 2) (CHF-2) (Class B basic helix-loop-helix protein 31) (bHLHb31) (HES-related repressor protein 1) (Hairy and enhancer of split-related protein 1) (HESR-1) (Hairy-related transcription factor 1) (HRT-1) (hHRT1)

Gene: HEY1
Organism: Homo sapiens
Interactions: 132
UniProt ID: Q9Y5J3

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 - cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1354209

HEY2
Hairy/enhancer-of-split related with YRPW motif protein 2

6

18

Small-scale

0.946

High

1054251

HES1
Transcription factor HES-1

4

18

Small-scale

0.893

High

1037557

OLIG2
Oligodendrocyte transcription factor 2

1

12

High-throughput

0.698

High

1378068

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

16

Small-scale

0.647

High

649177

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

7

Small-scale

0.621

High

546062

MYOD1
Myoblast determination protein 1

1

13

Small-scale

0.618

High

270750

MYCB2
E3 ubiquitin-protein ligase MYCBP2

2

1

Small-scale

0.611

High

472740

FBSP1
F-box/SPRY domain-containing protein 1

2

5

Small-scale

0.611

High

505015

HSP7C
Heat shock cognate 71 kDa protein

2

5

Small-scale

0.611

High

892139

ACTB
Actin, cytoplasmic 1

2

2

Small-scale

0.611

High

931955

CSK2B
Casein kinase II subunit beta

2

3

Small-scale

0.611

High

980671

TLE1
Transducin-like enhancer protein 1

2

20

Small-scale

0.611

High

1175278

TBA1A
Tubulin alpha-1A chain

2

6

Small-scale

0.611

High

270845

FOXH1
Forkhead box protein H1

2

2

High-throughput

0.606

High

1065219

DAZP2
DAZ-associated protein 2

2

1

High-throughput

0.606

High

1305658

PITX2
Pituitary homeobox 2

2

1

High-throughput

0.606

High

387809

P53
Cellular tumor antigen p53

2

2

Small-scale

0.602

High

1317064

YTHD1
YTH domain-containing family protein 1

2

0

High-throughput

0.580

High

1069677

STK38
Serine/threonine-protein kinase 38

1

1

Small-scale

0.578

High

1377228

ST38L
Serine/threonine-protein kinase 38-like

1

1

Small-scale

0.578

High

1069837

NONO
Non-POU domain-containing octamer-binding protein

1

2

Small-scale

0.561

High

1109284

KRA62
Keratin-associated protein 6-2

2

5

High-throughput

0.553

High

1243242

TET5D
Terminal nucleotidyltransferase 5D

2

2

High-throughput

0.553

High

1287273

PKHB2
Pleckstrin homology domain-containing family B member 2

2

2

High-throughput

0.553

High

883208

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

2

High-throughput

0.541

High

923302

RL11
Large ribosomal subunit protein uL5

1

0

Small-scale

0.537

High

241392

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

3

High-throughput

0.536

High

871846

HSP72
Heat shock-related 70 kDa protein 2

1

5

High-throughput

0.536

High

915542

ACTA
Actin, aortic smooth muscle

1

2

High-throughput

0.536

High

1122540

ACTBL
Beta-actin-like protein 2

1

2

High-throughput

0.536

High

639133

S100P
Protein S100-P

1

0

High-throughput

0.513

High

841368

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.513

High

1346917

PAPD1
Poly(A) RNA polymerase, mitochondrial

1

0

High-throughput

0.513

High

171466

SMAD9
Mothers against decapentaplegic homolog 9

1

4

High-throughput

0.508

High

521412

SKIL
Ski-like protein

1

1

High-throughput

0.508

High

950344

SMAD3
Mothers against decapentaplegic homolog 3

1

4

High-throughput

0.508

High

963041

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

Small-scale

0.501

High

1283482

SPSB4
SPRY domain-containing SOCS box protein 4

1

4

High-throughput

0.489

High

1304367

SORT
Sortilin

1

1

High-throughput

0.489

High

1318264

KPCD2
Serine/threonine-protein kinase D2

1

0

High-throughput

0.486

High

1345300

ZHANG
CREB/ATF bZIP transcription factor

1

0

Small-scale

0.480

High

381336

TBB4A
Tubulin beta-4A chain

1

5

Small-scale

0.479

High

428523

TBB5
Tubulin beta chain

1

5

Small-scale

0.479

High

438655

HS90B
Heat shock protein HSP 90-beta

1

3

Small-scale

0.479

High

443903

VIME
Vimentin

1

1

Small-scale

0.479

High

453735

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

2

Small-scale

0.479

High

502726

BIP
Endoplasmic reticulum chaperone BiP

1

6

Small-scale

0.479

High

571646

DDX5
Probable ATP-dependent RNA helicase DDX5

1

1

Small-scale

0.479

High

610126

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

2

Small-scale

0.479

High

626301

APC
Adenomatous polyposis coli protein

1

2

Small-scale

0.479

High

683041

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

1

Small-scale

0.479

High

771111

TCPZ
T-complex protein 1 subunit zeta

1

1

Small-scale

0.479

High

807605

RS10
Small ribosomal subunit protein eS10

1

1

Small-scale

0.479

High

833054

YLPM1
YLP motif-containing protein 1

1

3

Small-scale

0.479

High

843110

TCPQ
T-complex protein 1 subunit theta

1

1

Small-scale

0.479

High

904206

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

2

Small-scale

0.479

High

907794

RS15A
Small ribosomal subunit protein uS8

1

1

Small-scale

0.479

High

912407

SMD1
Small nuclear ribonucleoprotein Sm D1

1

1

Small-scale

0.479

High

912767

SMD3
Small nuclear ribonucleoprotein Sm D3

1

1

Small-scale

0.479

High

929135

SKP1
S-phase kinase-associated protein 1

1

2

Small-scale

0.479

High

933400

TBA1B
Tubulin alpha-1B chain

1

6

Small-scale

0.479

High

933684

TBA4A
Tubulin alpha-4A chain

1

6

Small-scale

0.479

High

934040

TBB4B
Tubulin beta-4B chain

1

5

Small-scale

0.479

High

934585

CSK21
Casein kinase II subunit alpha

1

11

Small-scale

0.479

High

967534

EWS
RNA-binding protein EWS

1

2

Small-scale

0.479

High

1037457

TBB3
Tubulin beta-3 chain

1

5

Small-scale

0.479

High

1046629

TBB2A
Tubulin beta-2A chain

1

5

Small-scale

0.479

High

1048299

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

2

Small-scale

0.479

High

1051532

DCTN1
Dynactin subunit 1

1

1

Small-scale

0.479

High

1061104

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

1

Small-scale

0.479

High

1113868

GRDN
Girdin

1

2

Small-scale

0.479

High

1183379

DDX46
Probable ATP-dependent RNA helicase DDX46

1

1

Small-scale

0.479

High

1198718

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

1

Small-scale

0.479

High

1244150

SYNE1
Nesprin-1

1

3

Small-scale

0.479

High

1261917

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

1

2

Small-scale

0.479

High

1263743

SYNE2
Nesprin-2

1

2

Small-scale

0.479

High

1270657

DPF3
Zinc finger protein DPF3

1

1

Small-scale

0.479

High

1318966

TB182
182 kDa tankyrase-1-binding protein

1

4

Small-scale

0.479

High

1354376

SE1L1
Protein sel-1 homolog 1

1

1

Small-scale

0.479

High

1039526

LAPM5
Lysosomal-associated transmembrane protein 5

1

1

High-throughput

0.464

High

57894

CCD78
Coiled-coil domain-containing protein 78

1

0

Small-scale

0.458

High

310112

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

1

0

Small-scale

0.458

High

444274

RS17
Small ribosomal subunit protein eS17

1

0

Small-scale

0.458

High

539206

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

Small-scale

0.458

High

547298

EZRI
Ezrin

1

0

Small-scale

0.458

High

598394

FLNA
Filamin-A

1

0

Small-scale

0.458

High

603821

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

Small-scale

0.458

High

616603

RS3
Small ribosomal subunit protein uS3

1

0

Small-scale

0.458

High

647999

MARK3
MAP/microtubule affinity-regulating kinase 3

1

0

Small-scale

0.458

High

671376

RL12
Large ribosomal subunit protein uL11

1

0

Small-scale

0.458

High

702195

RL9
Large ribosomal subunit protein uL6

1

0

Small-scale

0.458

High

759909

RS19
Small ribosomal subunit protein eS19

1

0

Small-scale

0.458

High

764431

FEN1
Flap endonuclease 1

1

0

Small-scale

0.458

High

807277

RS5
Small ribosomal subunit protein uS7

1

0

Small-scale

0.458

High

875479

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

893215

RS20
Small ribosomal subunit protein uS10

1

0

Small-scale

0.458

High

899422

RL15
Large ribosomal subunit protein eL15

1

0

Small-scale

0.458

High

905789

RS7
Small ribosomal subunit protein eS7

1

0

Small-scale

0.458

High

908242

RS16
Small ribosomal subunit protein uS9

1

0

Small-scale

0.458

High

910628

RS14
Small ribosomal subunit protein uS11

1

0

Small-scale

0.458

High

910975

RS18
Small ribosomal subunit protein uS13

1

0

Small-scale

0.458

High

911071

RS29
Small ribosomal subunit protein uS14

1

0

Small-scale

0.458

High

919593

RL23
Large ribosomal subunit protein uL14

1

0

Small-scale

0.458

High

920596

RS25
Small ribosomal subunit protein eS25

1

0

Small-scale

0.458

High

923608

RL8
Large ribosomal subunit protein uL2

1

0

Small-scale

0.458

High

931504

YBOX1
Y-box-binding protein 1

1

0

Small-scale

0.458

High

1020244

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

0

Small-scale

0.458

High

1062440

PAF15
PCNA-associated factor

1

0

Small-scale

0.458

High

1068715

PLEC
Plectin

1

0

Small-scale

0.458

High

1158047

M18BP
Mis18-binding protein 1

1

0

Small-scale

0.458

High

1261519

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

Small-scale

0.458

High

1287307

CC124
Coiled-coil domain-containing protein 124

1

0

Small-scale

0.458

High

1306131

CDC6
Cell division control protein 6 homolog

1

0

Small-scale

0.458

High

1336267

Q9HCK3
KIAA1569 protein

1

0

Small-scale

0.458

High

1344027

BIRC6
Baculoviral IAP repeat-containing protein 6

1

0

Small-scale

0.458

High

321262

PTBP3
Polypyrimidine tract-binding protein 3

1

2

High-throughput

0.445

High

483813

HS71B
Heat shock 70 kDa protein 1B

1

5

High-throughput

0.445

High

1081660

NTRK3
NT-3 growth factor receptor

1

2

Small-scale

0.439

High

1307598

AKAP9
A-kinase anchor protein 9

1

2

Small-scale

0.437

High

1326115

DERL2
Derlin-2

1

1

Small-scale

0.437

High

520773

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

0

High-throughput

0.279

Low

1241509

SPRY3
SPRY domain-containing protein 3

1

0

High-throughput

0.279

Low

1357037

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.279

Low

314904

FMNL1
Formin-like protein 1

1

0

Small-scale

0.249

Low

821478

TCPE
T-complex protein 1 subunit epsilon

1

0

Small-scale

0.249

Low

918976

RAB1A
Ras-related protein Rab-1A

1

0

Small-scale

0.249

Low

1053359

FRG1
Protein FRG1

1

0

Small-scale

0.249

Low

1150574

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

0

Small-scale

0.249

Low

1160093

RL22L
Ribosomal protein eL22-like

1

0

Small-scale

0.249

Low

1264832

TITIN
Titin

1

0

Small-scale

0.249

Low

1377386

TMA7
Translation machinery-associated protein 7

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024