Protein: SHC1
SHC-transforming protein 1 (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)

Gene: SHC1
Organism: Mus musculus
Interactions: 48
UniProt ID: P98083

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001784 - phosphotyrosine residue binding
GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005158 - insulin receptor binding
GO:0005159 - insulin-like growth factor receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1022218

GRB2
Growth factor receptor-bound protein 2

21

20

Small-scale

0.986

High

1022228

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

6

20

Small-scale

0.944

High

1022210

EGFR
Epidermal growth factor receptor

4

20

Small-scale

0.873

High

777186

PTN12
Tyrosine-protein phosphatase non-receptor type 12

3

20

Small-scale

0.867

High

1022224

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

2

20

Small-scale

0.789

High

686953

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

Small-scale

0.724

High

1022208

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.692

High

869539

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.691

High

1022214

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

1

7

High-throughput

0.691

High

1022221

TGFR2
TGF-beta receptor type-2

1

11

Small-scale

0.690

High

1022220

SOS1
Son of sevenless homolog 1

4

20

Small-scale

0.676

High

313431

GRAP2
GRB2-related adaptor protein 2

1

20

Small-scale

0.647

High

1022213

NTRK1
High affinity nerve growth factor receptor

1

20

Small-scale

0.647

High

1022230

GAB1
GRB2-associated-binding protein 1

3

20

Small-scale

0.636

High

205428

SOCS1
Suppressor of cytokine signaling 1

1

20

Small-scale

0.618

High

431339

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.618

High

767008

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

20

Small-scale

0.618

High

883404

PTPRE
Receptor-type tyrosine-protein phosphatase epsilon

1

20

Small-scale

0.618

High

1000395

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.618

High

1021890

ALK
ALK tyrosine kinase receptor

1

20

Small-scale

0.618

High

1022209

UFO
Tyrosine-protein kinase receptor UFO

1

20

Small-scale

0.618

High

1022222

TGFR1
TGF-beta receptor type-1

2

11

Small-scale

0.611

High

1022229

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

20

Small-scale

0.589

High

651513

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.536

High

1022216

Q3ZB59
Growth factor receptor bound protein 2-associated protein 2

2

20

Small-scale

0.533

High

867746

MK14
Mitogen-activated protein kinase 14

1

8

Small-scale

0.501

High

1022219

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.492

High

997222

TBA4A
Tubulin alpha-4A chain

1

20

High-throughput

0.489

High

593807

IL2RB
Interleukin-2 receptor subunit beta

1

20

Small-scale

0.479

High

772549

IRS1
Insulin receptor substrate 1

1

20

Small-scale

0.479

High

789720

THB
Thyroid hormone receptor beta

1

19

High-throughput

0.479

High

821232

CSF3R
Granulocyte colony-stimulating factor receptor

1

20

Small-scale

0.479

High

1021892

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

20

Small-scale

0.479

High

1022211

RUNX2
Runt-related transcription factor 2

1

4

Small-scale

0.479

High

1022212

STING
Stimulator of interferon genes protein

1

6

High-throughput

0.479

High

1022215

TAXB1
Tax1-binding protein 1 homolog

1

20

High-throughput

0.457

High

1022231

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

9

High-throughput

0.457

High

770696

CD22
B-cell receptor CD22

1

20

Small-scale

0.445

High

1022233

GAB2
GRB2-associated-binding protein 2

1

20

High-throughput

0.445

High

1022000

ATS1
A disintegrin and metalloproteinase with thrombospondin motifs 1

1

20

Small-scale

0.437

High

1022223

TEDC2
Tubulin epsilon and delta complex protein 2

1

1

High-throughput

0.437

High

1022227

TRI31
E3 ubiquitin-protein ligase TRIM31

1

19

Small-scale

0.437

High

516070

DCAM1
S-adenosylmethionine decarboxylase proenzyme 1

1

3

High-throughput

0.417

High

1022217

BRSK1
Serine/threonine-protein kinase BRSK1

1

13

High-throughput

0.417

High

1022232

SHCBP
SHC SH2 domain-binding protein 1

1

1

High-throughput

0.417

High

1022225

CBAR1
CBY1-interacting BAR domain-containing protein 1

1

0

High-throughput

0.249

Low

1022226

TTC23
Tetratricopeptide repeat protein 23

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025