Protein: HBB
Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Cleaved into: LVV-hemorphin-7; Spinorphin]

Gene: HBB
Organism: Homo sapiens
Interactions: 165
UniProt ID: P68871

Gene Ontology (top 5):
GO:0004601 - peroxidase activity
GO:0005344 - oxygen carrier activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

935762

HBA
Hemoglobin subunit alpha

15

18

Small-scale

0.984

High

355098

HBAZ
Hemoglobin subunit zeta

5

16

Small-scale

0.912

High

447717

HBAT
Hemoglobin subunit theta-1

2

17

High-throughput

0.783

High

935792

HBM
Hemoglobin subunit mu

2

18

High-throughput

0.783

High

341199

HPT
Haptoglobin

2

1

Small-scale

0.754

High

198430

KLK10
Kallikrein-10

1

2

High-throughput

0.691

High

355199

HBE
Hemoglobin subunit epsilon

1

18

High-throughput

0.691

High

439329

CATG
Cathepsin G

1

1

High-throughput

0.691

High

596341

ASPG
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase

3

1

High-throughput

0.667

High

935808

GDPD1
Lysophospholipase D GDPD1

3

2

High-throughput

0.667

High

935837

PGPI
Pyroglutamyl-peptidase 1

3

1

High-throughput

0.667

High

240476

CYTIP
Cytohesin-interacting protein

3

0

High-throughput

0.638

High

935811

JOS2
Josephin-2

3

0

High-throughput

0.638

High

935845

CSN3
COP9 signalosome complex subunit 3

3

0

High-throughput

0.638

High

935846

MGT4B
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B

3

0

High-throughput

0.634

High

935841

DACH1
Dachshund homolog 1

3

0

High-throughput

0.629

High

195975

PLXB1
Plexin-B1

2

2

High-throughput

0.628

High

420821

H2B1J
Histone H2B type 1-J

2

1

High-throughput

0.628

High

503874

HSP7C
Heat shock cognate 71 kDa protein

2

1

High-throughput

0.628

High

675609

GSTT1
Glutathione S-transferase theta-1

2

1

High-throughput

0.628

High

935783

MK06
Mitogen-activated protein kinase 6

2

3

High-throughput

0.628

High

935826

REN3A
Regulator of nonsense transcripts 3A

2

2

High-throughput

0.628

High

935829

MSL2
E3 ubiquitin-protein ligase MSL2

2

1

High-throughput

0.628

High

935788

NDUF5
Arginine-hydroxylase NDUFAF5, mitochondrial

3

1

High-throughput

0.609

High

602921

BMP5
Bone morphogenetic protein 5

2

0

High-throughput

0.602

High

906985

PRS8
26S proteasome regulatory subunit 8

2

0

High-throughput

0.602

High

935766

SEMG2
Semenogelin-2

2

0

High-throughput

0.602

High

646788

1433T
14-3-3 protein theta

2

4

High-throughput

0.601

High

935844

GRID1
Glutamate receptor ionotropic, delta-1

2

0

High-throughput

0.585

High

935770

FOXO1
Forkhead box protein O1

2

3

High-throughput

0.584

High

935813

GTR14
Solute carrier family 2, facilitated glucose transporter member 14

2

1

High-throughput

0.574

High

935820

PNKP
Bifunctional polynucleotide phosphatase/kinase

2

1

High-throughput

0.574

High

935777

ARHG6
Rho guanine nucleotide exchange factor 6

2

2

High-throughput

0.571

High

935771

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

2

1

High-throughput

0.549

High

82399

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

4

High-throughput

0.536

High

126374

MATN2
Matrilin-2

1

2

High-throughput

0.536

High

132821

SDCB1
Syntenin-1

1

2

High-throughput

0.536

High

146907

DHSD
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

1

1

High-throughput

0.536

High

281985

ANXA9
Annexin A9

1

1

High-throughput

0.536

High

328122

SG1D1
Secretoglobin family 1D member 1

1

2

High-throughput

0.536

High

331781

NSD2
Histone-lysine N-methyltransferase NSD2

1

1

High-throughput

0.536

High

447739

THIK
3-ketoacyl-CoA thiolase, peroxisomal

1

2

High-throughput

0.536

High

681404

DNJA1
DnaJ homolog subfamily A member 1

1

1

High-throughput

0.536

High

686163

GLPK
Glycerol kinase

1

1

High-throughput

0.536

High

922799

RL32
Large ribosomal subunit protein eL32

1

2

High-throughput

0.536

High

935772

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

1

High-throughput

0.536

High

935785

FNDC1
Fibronectin type III domain-containing protein 1

1

2

High-throughput

0.536

High

935787

FBLN7
Fibulin-7

1

1

High-throughput

0.536

High

935796

PXK
PX domain-containing protein kinase-like protein

1

3

High-throughput

0.536

High

935812

HMGC2
3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic

1

1

High-throughput

0.536

High

935818

KIFA3
Kinesin-associated protein 3

1

1

High-throughput

0.536

High

935821

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

3

High-throughput

0.536

High

935825

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

3

High-throughput

0.536

High

935839

DKK2
Dickkopf-related protein 2

1

1

High-throughput

0.536

High

935843

HDAC9
Histone deacetylase 9

1

4

High-throughput

0.536

High

541965

OXDA
D-amino-acid oxidase

1

0

High-throughput

0.513

High

572340

LEG3
Galectin-3

1

0

High-throughput

0.513

High

648010

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

1

0

High-throughput

0.513

High

816299

GLIP1
Glioma pathogenesis-related protein 1

1

0

High-throughput

0.513

High

882715

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

900367

RHOA
Transforming protein RhoA

1

0

High-throughput

0.513

High

935764

BNC1
Zinc finger protein basonuclin-1

1

0

High-throughput

0.513

High

935765

GCYA1
Guanylate cyclase soluble subunit alpha-1

1

0

High-throughput

0.513

High

935810

ZNRF1
E3 ubiquitin-protein ligase ZNRF1

1

0

High-throughput

0.513

High

935815

ITLN2
Intelectin-2

1

0

High-throughput

0.513

High

935830

PDE7B
3',5'-cyclic-AMP phosphodiesterase 7B

1

0

High-throughput

0.513

High

935851

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

2

Small-scale

0.501

High

935779

ETFD
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

1

0

High-throughput

0.493

High

173463

RER1
Protein RER1

1

1

High-throughput

0.489

High

183023

P2RX6
P2X purinoceptor 6

1

1

High-throughput

0.489

High

422377

NFM
Neurofilament medium polypeptide

1

4

High-throughput

0.489

High

798417

LPAR6
Lysophosphatidic acid receptor 6

1

1

High-throughput

0.489

High

801073

KI67
Proliferation marker protein Ki-67

1

3

High-throughput

0.489

High

935782

TAF12
Transcription initiation factor TFIID subunit 12

1

1

High-throughput

0.489

High

935784

HSDL1
Inactive hydroxysteroid dehydrogenase-like protein 1

1

2

High-throughput

0.489

High

935790

C1QL3
Complement C1q-like protein 3

1

1

High-throughput

0.489

High

935793

TTC19
Tetratricopeptide repeat protein 19, mitochondrial

1

2

High-throughput

0.489

High

935794

ARMD1
Armadillo-like helical domain containing protein 1

1

1

High-throughput

0.489

High

935799

CACL1
CDK2-associated and cullin domain-containing protein 1

1

1

High-throughput

0.489

High

935805

DTWD1
tRNA-uridine aminocarboxypropyltransferase 1

1

1

High-throughput

0.489

High

935814

ZDH19
Palmitoyltransferase ZDHHC19

1

2

High-throughput

0.489

High

935819

CI085
Uncharacterized protein C9orf85

1

1

High-throughput

0.489

High

935831

MED4
Mediator of RNA polymerase II transcription subunit 4

1

1

High-throughput

0.489

High

935832

RIC8A
Synembryn-A

1

1

High-throughput

0.489

High

935847

T3JAM
TRAF3-interacting JNK-activating modulator

1

4

High-throughput

0.489

High

935848

CDYL
Chromodomain Y-like protein

1

1

High-throughput

0.489

High

935849

PLLP
Plasmolipin

1

1

High-throughput

0.489

High

160507

AURKA
Aurora kinase A

1

2

High-throughput

0.479

High

282616

RNF8
E3 ubiquitin-protein ligase RNF8

1

1

High-throughput

0.479

High

322465

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

344186

A1AT
Alpha-1-antitrypsin

1

1

High-throughput

0.479

High

344287

AACT
Alpha-1-antichymotrypsin

1

2

High-throughput

0.479

High

361335

APOA1
Apolipoprotein A-I

1

1

High-throughput

0.479

High

364006

VTDB
Vitamin D-binding protein

1

1

High-throughput

0.479

High

364544

TRFE
Serotransferrin

1

2

High-throughput

0.479

High

364784

HEMO
Hemopexin

1

1

High-throughput

0.479

High

369370

ESR1
Estrogen receptor

1

5

High-throughput

0.479

High

377241

GCR
Glucocorticoid receptor

1

5

Small-scale

0.479

High

528959

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.479

High

601884

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

8

High-throughput

0.479

High

677815

LCN1
Lipocalin-1

1

1

High-throughput

0.479

High

681783

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

Small-scale

0.479

High

832358

MCM2
DNA replication licensing factor MCM2

1

3

High-throughput

0.479

High

890596

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

Small-scale

0.479

High

908347

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

935776

TNIP1
TNFAIP3-interacting protein 1

1

9

High-throughput

0.479

High

935780

PROL4
Proline-rich protein 4

1

1

High-throughput

0.479

High

935786

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

1

High-throughput

0.479

High

935797

ZN598
E3 ubiquitin-protein ligase ZNF598

1

2

High-throughput

0.479

High

935798

ARHGP
Rho guanine nucleotide exchange factor 25

1

2

High-throughput

0.479

High

935801

SLX4
Structure-specific endonuclease subunit SLX4

1

6

High-throughput

0.479

High

935817

REQU
Zinc finger protein ubi-d4

1

3

High-throughput

0.479

High

935822

CP250
Centrosome-associated protein CEP250

1

3

High-throughput

0.479

High

935823

FACD2
Fanconi anemia group D2 protein

1

4

High-throughput

0.479

High

935824

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.479

High

935840

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

935850

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.479

High

935769

DMWD
Dystrophia myotonica WD repeat-containing protein

1

1

High-throughput

0.470

High

329630

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.458

High

336772

CERU
Ceruloplasmin

1

0

High-throughput

0.458

High

363435

A1AG1
Alpha-1-acid glycoprotein 1

1

0

High-throughput

0.458

High

365305

STAT
Statherin

1

0

High-throughput

0.458

High

386502

P53
Cellular tumor antigen p53

1

0

Small-scale

0.458

High

625347

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

896029

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

935804

STAG2
Cohesin subunit SA-2

1

0

High-throughput

0.458

High

935828

SENP2
Sentrin-specific protease 2

1

0

Small-scale

0.458

High

935833

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

935834

PDLI7
PDZ and LIM domain protein 7

1

0

High-throughput

0.458

High

353921

IGHM
Immunoglobulin heavy constant mu

1

5

High-throughput

0.445

High

496823

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.445

High

882232

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

3

High-throughput

0.445

High

935773

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

2

High-throughput

0.445

High

260488

PITX3
Pituitary homeobox 3

1

2

Small-scale

0.437

High

823865

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.437

High

935778

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.437

High

935800

SMC5
Structural maintenance of chromosomes protein 5

1

3

High-throughput

0.437

High

935803

RHG24
Rho GTPase-activating protein 24

1

5

High-throughput

0.437

High

935816

ESR2
Estrogen receptor beta

1

5

High-throughput

0.437

High

935838

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

1

High-throughput

0.437

High

314977

SGPL1
Sphingosine-1-phosphate lyase 1

1

1

High-throughput

0.407

High

935768

GOGA2
Golgin subfamily A member 2

1

8

High-throughput

0.407

High

935774

GLPK3
Glycerol kinase 3

1

1

High-throughput

0.407

High

935795

TMM92
Transmembrane protein 92

3

0

High-throughput

0.347

High

58433

F234B
Protein FAM234B

2

0

High-throughput

0.328

High

169274

MDM4
Protein Mdm4

2

0

High-throughput

0.328

High

935827

LPAR2
Lysophosphatidic acid receptor 2

2

0

High-throughput

0.328

High

935807

PLPL1
Omega-hydroxyceramide transacylase

2

0

High-throughput

0.318

High

913389

SELT
Thioredoxin reductase-like selenoprotein T

1

0

High-throughput

0.282

High

237655

SEP15
Selenoprotein F

1

0

High-throughput

0.279

Low

239928

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.279

Low

620241

PAX3
Paired box protein Pax-3

1

0

High-throughput

0.279

Low

935767

HEN2
Helix-loop-helix protein 2

1

0

High-throughput

0.279

Low

935775

SL9A5
Sodium/hydrogen exchanger 5

1

0

High-throughput

0.279

Low

935789

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

0

High-throughput

0.279

Low

935791

MSL1
Male-specific lethal 1 homolog

1

0

High-throughput

0.279

Low

935802

APCD1
Protein APCDD1

1

0

High-throughput

0.279

Low

935806

FRMD1
FERM domain-containing protein 1

1

0

High-throughput

0.279

Low

935809

C2C4A
C2 calcium-dependent domain-containing protein 4A

1

0

High-throughput

0.279

Low

935836

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.279

Low

935842

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

0

High-throughput

0.279

Low

935781

SSX2
Protein SSX2

1

0

High-throughput

0.269

Low

631396

BRD2
Bromodomain-containing protein 2

1

0

High-throughput

0.249

Low

935763

EREP3
Protein ENTREP3

1

0

High-throughput

0.249

Low

935835

BMP2K
BMP-2-inducible protein kinase

1

0

Small-scale

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024