Protein: CO4A
Complement C4-A (Acidic complement C4) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2) [Cleaved into: Complement C4 beta chain; Complement C4-A alpha chain; C4a anaphylatoxin; C4b-A; C4d-A; Complement C4 gamma chain]

Gene: CO4A, C4A
Organism: Homo sapiens
Interactions: 83
UniProt ID: P0C0L4

Gene Ontology (top 5):
GO:0001849 - complement component C1q complex binding
GO:0004866 - endopeptidase inhibitor activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005788 - endoplasmic reticulum lumen

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

119683

MASP2
Mannan-binding lectin serine protease 2

4

8

Small-scale

0.882

High

246334

SCN2B
Sodium channel subunit beta-2

3

4

High-throughput

0.861

High

416129

CO2
Complement C2

2

20

Small-scale

0.778

High

469842

PVR
Poliovirus receptor

2

0

High-throughput

0.770

High

469870

VSIG1
V-set and immunoglobulin domain-containing protein 1

2

1

High-throughput

0.726

High

455002

C1S
Complement C1s subcomponent

1

7

Small-scale

0.724

High

126347

MATN2
Matrilin-2

1

3

High-throughput

0.691

High

469864

CD226
CD226 antigen

1

2

High-throughput

0.691

High

121088

LEG8
Galectin-8

3

7

High-throughput

0.667

High

469841

CCL5
C-C motif chemokine 5

2

2

High-throughput

0.628

High

469849

MASP1
Mannan-binding lectin serine protease 1

1

7

Small-scale

0.618

High

469878

FHR4
Complement factor H-related protein 4

1

20

Small-scale

0.618

High

469886

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

2

4

High-throughput

0.611

High

469874

GDPD1
Lysophospholipase D GDPD1

3

2

High-throughput

0.609

High

469840

LAMP1
Lysosome-associated membrane glycoprotein 1

2

0

High-throughput

0.602

High

469847

S15A1
Solute carrier family 15 member 1

2

0

High-throughput

0.602

High

469856

AT2B2
Plasma membrane calcium-transporting ATPase 2

2

0

High-throughput

0.602

High

469866

OCLN
Occludin

2

0

High-throughput

0.602

High

469894

PILRA
Paired immunoglobulin-like type 2 receptor alpha

1

0

Small-scale

0.586

High

469884

SNX27
Sorting nexin-27

2

1

High-throughput

0.574

High

183015

P2RX6
P2X purinoceptor 6

1

4

High-throughput

0.536

High

239732

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

3

High-throughput

0.536

High

328099

SG1D1
Secretoglobin family 1D member 1

1

4

High-throughput

0.536

High

393988

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.536

High

469843

AATC
Aspartate aminotransferase, cytoplasmic

1

3

High-throughput

0.536

High

469851

STX17
Syntaxin-17

1

4

High-throughput

0.536

High

469869

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

1

High-throughput

0.536

High

469872

NRSN1
Neurensin-1

1

3

High-throughput

0.536

High

469881

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

4

High-throughput

0.536

High

469885

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

1

High-throughput

0.536

High

345763

MYC
Myc proto-oncogene protein

2

3

High-throughput

0.521

High

469845

APC
Adenomatous polyposis coli protein

1

0

High-throughput

0.518

High

363700

ALBU
Albumin

1

0

High-throughput

0.513

High

435937

MSMB
Beta-microseminoprotein

1

0

High-throughput

0.513

High

469846

INGR2
Interferon gamma receptor 2

1

0

High-throughput

0.513

High

469855

IL5RA
Interleukin-5 receptor subunit alpha

1

0

High-throughput

0.513

High

431454

HS90A
Heat shock protein HSP 90-alpha

1

2

Small-scale

0.501

High

469844

HXB6
Homeobox protein Hox-B6

1

3

High-throughput

0.489

High

469853

HXA4
Homeobox protein Hox-A4

1

3

High-throughput

0.489

High

469854

HXC5
Homeobox protein Hox-C5

1

3

High-throughput

0.489

High

469873

RYBP
RING1 and YY1-binding protein

1

5

High-throughput

0.489

High

469880

PIGT
GPI transamidase component PIG-T

1

3

High-throughput

0.489

High

469882

SARAF
Store-operated calcium entry-associated regulatory factor

1

3

High-throughput

0.489

High

469892

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

1

High-throughput

0.489

High

469896

SSUH2
Protein SSUH2 homolog

1

4

High-throughput

0.489

High

344818

CYTC
Cystatin-C

1

0

Small-scale

0.480

High

204960

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

362733

FINC
Fibronectin

1

4

Small-scale

0.479

High

373572

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.479

High

469875

NHLC2
NHL repeat-containing protein 2

1

2

High-throughput

0.479

High

469890

TRI31
E3 ubiquitin-protein ligase TRIM31

1

2

High-throughput

0.479

High

122461

MEN1
Menin

1

0

High-throughput

0.458

High

429805

CATL1
Procathepsin L

1

0

Small-scale

0.458

High

469857

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

Small-scale

0.445

High

469861

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.445

High

469895

ITM2B
Integral membrane protein 2B

1

5

High-throughput

0.445

High

385964

P53
Cellular tumor antigen p53

1

1

High-throughput

0.437

High

469848

SOX2
Transcription factor SOX-2

1

4

High-throughput

0.437

High

469852

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.437

High

469858

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.437

High

469859

FOXO1
Forkhead box protein O1

1

7

High-throughput

0.437

High

469860

FOXC1
Forkhead box protein C1

1

7

High-throughput

0.437

High

469862

KIF22
Kinesin-like protein KIF22

1

1

High-throughput

0.437

High

469871

ASXL1
Polycomb group protein ASXL1

1

3

High-throughput

0.437

High

469876

FBX22
F-box only protein 22

1

1

High-throughput

0.437

High

469877

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.437

High

469879

TF3B
Transcription factor IIIB 90 kDa subunit

1

1

Small-scale

0.437

High

469887

FACD2
Fanconi anemia group D2 protein

1

6

High-throughput

0.437

High

469889

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

3

Small-scale

0.437

High

469891

ASXL3
Putative Polycomb group protein ASXL3

1

4

High-throughput

0.437

High

469893

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.437

High

469888

TX101
Testis-expressed protein 101

1

0

High-throughput

0.426

High

200478

CP110
Centriolar coiled-coil protein of 110 kDa

1

1

High-throughput

0.407

High

469867

CP135
Centrosomal protein of 135 kDa

1

1

High-throughput

0.407

High

58570

TMM89
Transmembrane protein 89

3

0

High-throughput

0.342

High

469868

F171B
Protein FAM171B

2

0

High-throughput

0.328

High

469863

FL2D
Pre-mRNA-splicing regulator WTAP

1

0

High-throughput

0.279

Low

128002

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

0

High-throughput

0.249

Low

298087

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.249

Low

469850

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.249

Low

469865

TAF9
Transcription initiation factor TFIID subunit 9

1

0

High-throughput

0.249

Low

469883

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

469897

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024