Protein: APR
Phorbol-12-myristate-13-acetate-induced protein 1 (PMA-induced protein 1) (Immediate-early-response protein APR) (Protein Noxa)

Gene: APR, PMAIP1
Organism: Homo sapiens
Interactions: 180
UniProt ID: Q13794

Gene Ontology (top 5):
GO:0001836 - release of cytochrome c from mitochondria
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

992164

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

22

7

Small-scale

0.988

High

992074

B2CL1
Bcl-2-like protein 1

4

7

Small-scale

0.885

High

489415

BCL2
Apoptosis regulator Bcl-2

3

7

Small-scale

0.861

High

1045344

B2CL2
Bcl-2-like protein 2

1

7

Small-scale

0.692

High

895071

RAB2A
Ras-related protein Rab-2A

3

3

High-throughput

0.653

High

991998

BAX
Apoptosis regulator BAX

1

7

Small-scale

0.618

High

1045324

IRF3
Interferon regulatory factor 3

2

1

Small-scale

0.584

High

1045374

CHIP
E3 ubiquitin-protein ligase CHIP

1

0

High-throughput

0.537

High

1045332

B2LA1
Bcl-2-related protein A1

1

7

Small-scale

0.527

High

983973

ZBT16
Zinc finger and BTB domain-containing protein 16

1

0

High-throughput

0.518

High

1045364

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.513

High

849327

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

2

High-throughput

0.501

High

919725

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

2

High-throughput

0.501

High

1045371

RBX2
RING-box protein 2

1

1

Small-scale

0.501

High

835738

GSK3B
Glycogen synthase kinase-3 beta

1

0

High-throughput

0.486

High

204663

E41L2
Band 4.1-like protein 2

1

2

High-throughput

0.479

High

299893

ERLN2
Erlin-2

1

1

High-throughput

0.479

High

350156

RASK
GTPase KRas

1

7

High-throughput

0.479

High

391393

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

3

High-throughput

0.479

High

423225

PDIA1
Protein disulfide-isomerase

1

1

High-throughput

0.479

High

506387

RALA
Ras-related protein Ral-A

1

6

High-throughput

0.479

High

542313

PLAK
Junction plakoglobin

1

1

High-throughput

0.479

High

547043

EZRI
Ezrin

1

2

High-throughput

0.479

High

574672

ARF4
ADP-ribosylation factor 4

1

1

High-throughput

0.479

High

590908

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

592242

RAB5A
Ras-related protein Rab-5A

1

3

High-throughput

0.479

High

592659

RAB6A
Ras-related protein Rab-6A

1

4

High-throughput

0.479

High

670705

PRDX6
Peroxiredoxin-6

1

1

High-throughput

0.479

High

844916

RAB7A
Ras-related protein Rab-7a

1

4

High-throughput

0.479

High

845473

RAB9A
Ras-related protein Rab-9A

1

4

High-throughput

0.479

High

893988

CDC42
Cell division control protein 42 homolog

1

1

High-throughput

0.479

High

895483

RAB10
Ras-related protein Rab-10

1

2

High-throughput

0.479

High

896439

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

2

High-throughput

0.479

High

896614

RAB14
Ras-related protein Rab-14

1

3

High-throughput

0.479

High

900455

RHOA
Transforming protein RhoA

1

1

High-throughput

0.479

High

908509

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

914060

RB11A
Ras-related protein Rab-11A

1

1

High-throughput

0.479

High

919624

RAP1A
Ras-related protein Rap-1A

1

5

High-throughput

0.479

High

920962

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

1

High-throughput

0.479

High

921256

RBX1
E3 ubiquitin-protein ligase RBX1

1

1

High-throughput

0.479

High

921558

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

1

High-throughput

0.479

High

923824

FKB1A
Peptidyl-prolyl cis-trans isomerase FKBP1A

1

1

High-throughput

0.479

High

926582

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

3

High-throughput

0.479

High

961544

FKBP3
Peptidyl-prolyl cis-trans isomerase FKBP3

1

1

High-throughput

0.479

High

966064

LAT1
Large neutral amino acids transporter small subunit 1

1

2

High-throughput

0.479

High

1017625

STX4
Syntaxin-4

1

2

High-throughput

0.479

High

1045325

PDIA6
Protein disulfide-isomerase A6

1

2

High-throughput

0.479

High

1045327

RAB35
Ras-related protein Rab-35

1

3

High-throughput

0.479

High

1045330

VAMP3
Vesicle-associated membrane protein 3

1

2

High-throughput

0.479

High

1045343

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

1

1

High-throughput

0.479

High

1045345

IRF7
Interferon regulatory factor 7

1

1

Small-scale

0.479

High

1045348

UBE2F
NEDD8-conjugating enzyme UBE2F

1

2

Small-scale

0.479

High

1045357

AN32E
Acidic leucine-rich nuclear phosphoprotein 32 family member E

1

1

High-throughput

0.479

High

1045359

RAB1B
Ras-related protein Rab-1B

1

1

High-throughput

0.479

High

1045366

ARL8B
ADP-ribosylation factor-like protein 8B

1

2

High-throughput

0.479

High

1045373

STML2
Stomatin-like protein 2, mitochondrial

1

1

High-throughput

0.479

High

1045376

E41L3
Band 4.1-like protein 3

1

2

High-throughput

0.479

High

1045377

RAP2C
Ras-related protein Rap-2c

1

5

High-throughput

0.479

High

118031

SNP23
Synaptosomal-associated protein 23

1

0

High-throughput

0.458

High

119635

STXB3
Syntaxin-binding protein 3

1

0

High-throughput

0.458

High

123591

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.458

High

130240

HMGN4
High mobility group nucleosome-binding domain-containing protein 4

1

0

High-throughput

0.458

High

206746

B2L11
Bcl-2-like protein 11

1

0

Small-scale

0.458

High

214926

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.458

High

240388

SNX2
Sorting nexin-2

1

0

High-throughput

0.458

High

242715

IF2P
Eukaryotic translation initiation factor 5B

1

0

High-throughput

0.458

High

254898

CPNE3
Copine-3

1

0

High-throughput

0.458

High

260076

VATG1
V-type proton ATPase subunit G 1

1

0

High-throughput

0.458

High

278809

DNJC8
DnaJ homolog subfamily C member 8

1

0

High-throughput

0.458

High

335811

COX2
Cytochrome c oxidase subunit 2

1

0

High-throughput

0.458

High

396933

HMGN1
Non-histone chromosomal protein HMG-14

1

0

High-throughput

0.458

High

427551

ANXA2
Annexin A2

1

0

High-throughput

0.458

High

451897

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

0

High-throughput

0.458

High

456565

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

0

Small-scale

0.458

High

514833

MPRI
Cation-independent mannose-6-phosphate receptor

1

0

High-throughput

0.458

High

519782

KCRU
Creatine kinase U-type, mitochondrial

1

0

High-throughput

0.458

High

525498

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

533456

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

554394

COX7C
Cytochrome c oxidase subunit 7C, mitochondrial

1

0

High-throughput

0.458

High

556863

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

Small-scale

0.458

High

652847

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

671657

PEBP1
Phosphatidylethanolamine-binding protein 1

1

0

High-throughput

0.458

High

718837

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

725433

COPB2
Coatomer subunit beta'

1

0

High-throughput

0.458

High

726193

BASI
Basigin

1

0

High-throughput

0.458

High

741971

TALDO
Transaldolase

1

0

High-throughput

0.458

High

777447

MDHC
Malate dehydrogenase, cytoplasmic

1

0

High-throughput

0.458

High

838637

GDIB
Rab GDP dissociation inhibitor beta

1

0

High-throughput

0.458

High

847464

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

848846

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

0

High-throughput

0.458

High

853276

IMA1
Importin subunit alpha-1

1

0

High-throughput

0.458

High

870644

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

873031

KAD2
Adenylate kinase 2, mitochondrial

1

0

High-throughput

0.458

High

874506

XPO2
Exportin-2

1

0

High-throughput

0.458

High

885780

MTPN
Myotrophin

1

0

High-throughput

0.458

High

897515

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

907021

PRS8
26S proteasome regulatory subunit 8

1

0

High-throughput

0.458

High

1026676

PRDX4
Peroxiredoxin-4

1

0

High-throughput

0.458

High

1036561

SQSTM
Sequestosome-1

1

0

Small-scale

0.458

High

1045326

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.458

High

1045331

NEDD8
NEDD8

1

0

High-throughput

0.458

High

1045333

TB10B
TBC1 domain family member 10B

1

0

High-throughput

0.458

High

1045334

COA6
Cytochrome c oxidase assembly factor 6 homolog

1

0

High-throughput

0.458

High

1045336

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

Small-scale

0.458

High

1045342

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.458

High

1045346

CUL5
Cullin-5

1

0

Small-scale

0.458

High

1045347

STMN2
Stathmin-2

1

0

High-throughput

0.458

High

1045350

CC124
Coiled-coil domain-containing protein 124

1

0

High-throughput

0.458

High

1045351

ERO1A
ERO1-like protein alpha

1

0

High-throughput

0.458

High

1045353

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.458

High

1045354

DNJC7
DnaJ homolog subfamily C member 7

1

0

High-throughput

0.458

High

1045355

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

1045361

GCP60
Golgi resident protein GCP60

1

0

High-throughput

0.458

High

1045362

DNJC5
DnaJ homolog subfamily C member 5

1

0

High-throughput

0.458

High

1045363

SFXN1
Sideroflexin-1

1

0

High-throughput

0.458

High

1045367

NDUBB
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

1

0

High-throughput

0.458

High

1045368

HYPK
Huntingtin-interacting protein K

1

0

High-throughput

0.458

High

1045370

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.458

High

1045375

HIG1A
HIG1 domain family member 1A, mitochondrial

1

0

High-throughput

0.458

High

1045378

TBL2
Transducin beta-like protein 2

1

0

High-throughput

0.458

High

178526

STX7
Syntaxin-7

1

2

High-throughput

0.437

High

263236

SC22B
Vesicle-trafficking protein SEC22b

1

1

High-throughput

0.437

High

325965

GNA14
Guanine nucleotide-binding protein subunit alpha-14

1

2

High-throughput

0.437

High

393195

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

High-throughput

0.437

High

393441

AT1B1
Sodium/potassium-transporting ATPase subunit beta-1

1

1

High-throughput

0.437

High

444729

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

3

High-throughput

0.437

High

561571

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

2

High-throughput

0.437

High

588599

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

3

High-throughput

0.437

High

619232

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

3

High-throughput

0.437

High

676543

CTR1
High affinity cationic amino acid transporter 1

1

1

High-throughput

0.437

High

792705

EAA1
Excitatory amino acid transporter 1

1

1

High-throughput

0.437

High

809904

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

1

High-throughput

0.437

High

833210

TMEDA
Transmembrane emp24 domain-containing protein 10

1

2

High-throughput

0.437

High

844513

RAB5C
Ras-related protein Rab-5C

1

4

High-throughput

0.437

High

850564

VAMP7
Vesicle-associated membrane protein 7

1

1

High-throughput

0.437

High

872021

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

1

High-throughput

0.437

High

905423

RRAS2
Ras-related protein R-Ras2

1

7

High-throughput

0.437

High

1045328

TMED2
Transmembrane emp24 domain-containing protein 2

1

2

High-throughput

0.437

High

1045329

AAAT
Neutral amino acid transporter B(0)

1

1

High-throughput

0.437

High

1045337

STX12
Syntaxin-12

1

2

High-throughput

0.437

High

1045338

AT11C
Phospholipid-transporting ATPase IG

1

1

High-throughput

0.437

High

1045339

TXND5
Thioredoxin domain-containing protein 5

1

2

High-throughput

0.437

High

1045341

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

1

High-throughput

0.437

High

1045352

BT3L4
Transcription factor BTF3 homolog 4

1

1

High-throughput

0.437

High

1045358

TMED9
Transmembrane emp24 domain-containing protein 9

1

2

High-throughput

0.437

High

1045360

TMX1
Thioredoxin-related transmembrane protein 1

1

3

High-throughput

0.437

High

1045379

SRPRB
Signal recognition particle receptor subunit beta

1

1

High-throughput

0.437

High

59753

KLRG2
Killer cell lectin-like receptor subfamily G member 2

1

0

High-throughput

0.249

Low

131145

ZN593
Zinc finger protein 593

1

0

High-throughput

0.249

Low

156503

SCAM3
Secretory carrier-associated membrane protein 3

1

0

High-throughput

0.249

Low

202755

TPD54
Tumor protein D54

1

0

High-throughput

0.249

Low

274090

XRP2
Protein XRP2

1

0

High-throughput

0.249

Low

276442

FACE1
CAAX prenyl protease 1 homolog

1

0

High-throughput

0.249

Low

307810

ZRAB2
Zinc finger Ran-binding domain-containing protein 2

1

0

High-throughput

0.249

Low

364266

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.249

Low

382414

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

0

High-throughput

0.249

Low

390876

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

437350

4F2
Amino acid transporter heavy chain SLC3A2

1

0

High-throughput

0.249

Low

536087

CD99
CD99 antigen

1

0

High-throughput

0.249

Low

536358

GLU2B
Glucosidase 2 subunit beta

1

0

High-throughput

0.249

Low

537207

CX7A2
Cytochrome c oxidase subunit 7A2, mitochondrial

1

0

High-throughput

0.249

Low

594904

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

0

High-throughput

0.249

Low

670874

DOPD
D-dopachrome decarboxylase

1

0

High-throughput

0.249

Low

762977

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.249

Low

822556

PIPNB
Phosphatidylinositol transfer protein beta isoform

1

0

High-throughput

0.249

Low

825411

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.249

Low

866942

MOT1
Monocarboxylate transporter 1

1

0

High-throughput

0.249

Low

873916

S12A2
Solute carrier family 12 member 2

1

0

High-throughput

0.249

Low

946518

DCD
Dermcidin

1

0

High-throughput

0.249

Low

990440

CKAP4
Cytoskeleton-associated protein 4

1

0

High-throughput

0.249

Low

1045322

COX17
Cytochrome c oxidase copper chaperone

1

0

High-throughput

0.249

Low

1045323

DSG2
Desmoglein-2

1

0

High-throughput

0.249

Low

1045335

ATRAP
Type-1 angiotensin II receptor-associated protein

1

0

High-throughput

0.249

Low

1045340

KLDC4
Kelch domain-containing protein 4

1

0

High-throughput

0.249

Low

1045349

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.249

Low

1045356

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.249

Low

1045365

CC50A
Cell cycle control protein 50A

1

0

High-throughput

0.249

Low

1045369

HACD3
Very-long-chain

1

0

High-throughput

0.249

Low

1045372

GBG12

1

0

High-throughput

0.249

Low

364051

CXCL7
Platelet basic protein

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024