Protein: DDIT4
DNA damage-inducible transcript 4 protein (HIF-1 responsive protein RTP801) (Protein regulated in development and DNA damage response 1) (REDD-1)

Gene: DDIT4
Organism: Homo sapiens
Interactions: 32
UniProt ID: Q9NX09

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0001764 - neuron migration
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1192244

HUWE1
E3 ubiquitin-protein ligase HUWE1

2

1

Small-scale

0.611

High

1043257

CUL4A
Cullin-4A

2

0

Small-scale

0.585

High

927580

1433Z
14-3-3 protein zeta/delta

2

1

Small-scale

0.571

High

228881

PRKN
E3 ubiquitin-protein ligase parkin

1

1

Small-scale

0.561

High

836031

GSK3B
Glycogen synthase kinase-3 beta

1

1

Small-scale

0.561

High

1082424

DDB1
DNA damage-binding protein 1

1

1

Small-scale

0.554

High

1330185

TXNIP
Thioredoxin-interacting protein

1

0

Small-scale

0.537

High

1130656

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.536

High

1347649

FBW1A
F-box/WD repeat-containing protein 1A

1

0

Small-scale

0.530

High

714439

HSP74
Heat shock 70 kDa protein 4

1

0

High-throughput

0.518

High

896386

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

1

High-throughput

0.515

High

182217

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

1

High-throughput

0.508

High

772183

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.493

High

1049341

KEAP1
Kelch-like ECH-associated protein 1

1

0

High-throughput

0.493

High

1158406

PMF1
Polyamine-modulated factor 1

1

0

High-throughput

0.493

High

1347650

MTF2
Metal-response element-binding transcription factor 2

1

0

High-throughput

0.493

High

1080910

HSPB2
Heat shock protein beta-2

1

0

High-throughput

0.486

High

683754

1433B
14-3-3 protein beta/alpha

1

1

Small-scale

0.479

High

808294

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

1

Small-scale

0.479

High

885458

VSX2
Visual system homeobox 2

1

1

High-throughput

0.470

High

1123678

DCAF6
DDB1- and CUL4-associated factor 6

1

0

High-throughput

0.458

High

1137580

RIF1
Telomere-associated protein RIF1

1

0

High-throughput

0.438

High

233791

NDK8
Putative nucleoside diphosphate kinase

1

1

High-throughput

0.437

High

476466

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

Small-scale

0.426

High

581063

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

0

Small-scale

0.426

High

437489

4F2
Amino acid transporter heavy chain SLC3A2

1

0

High-throughput

0.268

Low

557502

PECA1
Platelet endothelial cell adhesion molecule

1

0

High-throughput

0.268

Low

884254

KLF3
Krueppel-like factor 3

1

0

High-throughput

0.268

Low

1110380

FX4L6
Forkhead box protein D4-like 6

1

0

High-throughput

0.268

Low

1297977

ZN488
Zinc finger protein 488

1

0

High-throughput

0.268

Low

1133131

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.251

Low

1146194

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024