Protein: SIGIR
Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8)

Gene: SIGIR, SIGIRR
Organism: Homo sapiens
Interactions: 16
UniProt ID: Q6IA17

Gene Ontology (top 5):
GO:0001960 - negative regulation of cytokine-mediated signaling pathway
GO:0005886 - plasma membrane
GO:0006953 - acute-phase response
GO:0007166 - cell surface receptor signaling pathway
GO:0009986 - cell surface

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

126315

TLR4
Toll-like receptor 4

2

18

Small-scale

0.776

High

575756

IL1R1
Interleukin-1 receptor type 1

2

13

Small-scale

0.754

High

1233228

SIGIR
Single Ig IL-1-related receptor

1

15

Small-scale

0.665

High

905596

IRAK1
Interleukin-1 receptor-associated kinase 1

2

20

Small-scale

0.601

High

1233230

TRAF6
TNF receptor-associated factor 6

2

20

Small-scale

0.601

High

1233229

MYD88
Myeloid differentiation primary response protein MyD88

2

15

Small-scale

0.584

High

125500

LEG9
Galectin-9

1

1

High-throughput

0.536

High

127352

LEG8
Galectin-8

1

1

High-throughput

0.536

High

479147

ENOG
Gamma-enolase

1

0

High-throughput

0.518

High

422324

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

64692

PALM3
Paralemmin-3

1

0

Small-scale

0.484

High

375618

RASK
GTPase KRas

1

8

High-throughput

0.479

High

891622

GSK3B
Glycogen synthase kinase-3 beta

1

4

Small-scale

0.479

High

417499

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.438

High

406283

MYCN
N-myc proto-oncogene protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025