Protein: IL1R1
Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]

Gene: IL1R1
Organism: Homo sapiens
Interactions: 39
UniProt ID: P14778

Gene Ontology (top 5):
GO:0002020 - protease binding
GO:0004888 - transmembrane signaling receptor activity
GO:0004908 - interleukin-1 receptor activity
GO:0004909 - interleukin-1, type I, activating receptor activity
GO:0005161 - platelet-derived growth factor receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

575765

IL1AP
Interleukin-1 receptor accessory protein

6

13

Small-scale

0.935

High

575743

IL1RA
Interleukin-1 receptor antagonist protein

3

9

Small-scale

0.853

High

378540

IL1B
Interleukin-1 beta

3

12

Small-scale

0.840

High

575750

MFAP3
Microfibril-associated glycoprotein 3

2

0

High-throughput

0.770

High

575756

SIGIR
Single Ig IL-1-related receptor

2

13

Small-scale

0.754

High

575749

IRAK1
Interleukin-1 receptor-associated kinase 1

10

10

Small-scale

0.753

High

575763

MYD88
Myeloid differentiation primary response protein MyD88

11

13

Small-scale

0.752

High

575769

TRAF6
TNF receptor-associated factor 6

8

8

Small-scale

0.746

High

163229

TR10B
Tumor necrosis factor receptor superfamily member 10B

2

6

High-throughput

0.628

High

575747

BMR1A
Bone morphogenetic protein receptor type-1A

2

1

High-throughput

0.628

High

378469

IL1A
Interleukin-1 alpha

1

2

Small-scale

0.618

High

484035

PGFRB
Platelet-derived growth factor receptor beta

1

18

Small-scale

0.618

High

575744

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

12

Small-scale

0.584

High

575764

TOLIP
Toll-interacting protein

2

7

Small-scale

0.584

High

575753

TBB8
Tubulin beta-8 chain

2

7

High-throughput

0.574

High

575767

CILK1
Serine/threonine-protein kinase ICK

2

7

High-throughput

0.574

High

575759

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

2

High-throughput

0.536

High

575761

VPS39
Vam6/Vps39-like protein

1

5

High-throughput

0.536

High

210171

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

12

Small-scale

0.515

High

575746

MYH10
Myosin-10

1

2

High-throughput

0.515

High

575748

MATR3
Matrin-3

1

3

High-throughput

0.515

High

575757

TCAM2
TIR domain-containing adapter molecule 2

1

1

Small-scale

0.515

High

575766

IRAK4
Interleukin-1 receptor-associated kinase 4

1

2

Small-scale

0.515

High

256442

TOM1
Target of Myb1 membrane trafficking protein

1

17

Small-scale

0.479

High

462969

YES
Tyrosine-protein kinase Yes

1

20

Small-scale

0.479

High

463309

LYN
Tyrosine-protein kinase Lyn

1

18

Small-scale

0.479

High

557058

SRC
Proto-oncogene tyrosine-protein kinase Src

1

18

Small-scale

0.479

High

575741

CSF2R
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

1

16

Small-scale

0.479

High

575742

EGR1
Early growth response protein 1

1

3

High-throughput

0.479

High

575745

AKT1
RAC-alpha serine/threonine-protein kinase

1

11

Small-scale

0.479

High

575751

RAC1
Ras-related C3 botulinum toxin substrate 1

1

12

Small-scale

0.479

High

575754

FREM1
FRAS1-related extracellular matrix protein 1

1

5

Small-scale

0.479

High

575755

MARH8
E3 ubiquitin-protein ligase MARCHF8

1

3

Small-scale

0.479

High

575760

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

1

Small-scale

0.479

High

575752

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

0

Small-scale

0.458

High

575758

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

1

0

High-throughput

0.458

High

575762

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

10

Small-scale

0.445

High

575768

TMED7
Transmembrane emp24 domain-containing protein 7

1

4

Small-scale

0.437

High

317787

LTN1
E3 ubiquitin-protein ligase listerin

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025