Protein: RAG1
V(D)J recombination-activating protein 1 (RAG-1) (RING finger protein 74) [Includes: Endonuclease RAG1 (EC 3.1.-.-); E3 ubiquitin-protein ligase RAG1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RAG1)]

Gene: RAG1
Organism: Homo sapiens
Interactions: 43
UniProt ID: P15918

Gene Ontology (top 5):
GO:0002250 - adaptive immune response
GO:0002331 - pre-B cell allelic exclusion
GO:0003677 - DNA binding
GO:0004519 - endonuclease activity
GO:0004842 - ubiquitin-protein transferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

587377

RAG2
V(D)J recombination-activating protein 2

6

1

Small-scale

0.941

High

587380

UB2D2
Ubiquitin-conjugating enzyme E2 D2

4

20

Small-scale

0.888

High

587368

RAG1
V(D)J recombination-activating protein 1

2

19

Small-scale

0.778

High

587374

UB2D1
Ubiquitin-conjugating enzyme E2 D1

2

20

Small-scale

0.778

High

587378

UBE2H
Ubiquitin-conjugating enzyme E2 H

2

20

Small-scale

0.778

High

587389

H31T
Histone H3.1t

1

10

Small-scale

0.761

High

587376

IMA5
Importin subunit alpha-5

3

13

Small-scale

0.682

High

144161

UBE2C
Ubiquitin-conjugating enzyme E2 C

1

20

Small-scale

0.647

High

507496

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

Small-scale

0.647

High

587373

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

20

Small-scale

0.647

High

587382

H31
Histone H3.1

1

10

Small-scale

0.647

High

587390

H2A2C
Histone H2A type 2-C

1

7

Small-scale

0.647

High

587391

H2B2E
Histone H2B type 2-E

1

9

Small-scale

0.647

High

587399

DCAF1
DDB1- and CUL4-associated factor 1

1

17

Small-scale

0.586

High

587385

CUL4A
Cullin-4A

2

20

Small-scale

0.584

High

587375

IMA1
Importin subunit alpha-1

2

13

Small-scale

0.584

High

587388

DDB1
DNA damage-binding protein 1

1

5

Small-scale

0.536

High

587394

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.515

High

413131

P53
Cellular tumor antigen p53

1

14

Small-scale

0.501

High

421439

A4
Amyloid-beta precursor protein

1

11

High-throughput

0.501

High

481073

HMGB1
High mobility group protein B1

1

16

Small-scale

0.501

High

587371

HMGB2
High mobility group protein B2

1

18

Small-scale

0.501

High

587379

H4
Histone H4

1

7

Small-scale

0.501

High

156918

CTRO
Citron Rho-interacting kinase

1

11

High-throughput

0.479

High

461112

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.479

High

468032

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.479

High

587369

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.479

High

587372

CRK
Adapter molecule crk

1

20

High-throughput

0.479

High

587381

RBX1
E3 ubiquitin-protein ligase RBX1

1

3

Small-scale

0.479

High

587383

RUNX1
Runt-related transcription factor 1

1

2

Small-scale

0.479

High

587384

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

6

High-throughput

0.479

High

587386

MDC1
Mediator of DNA damage checkpoint protein 1

1

14

Small-scale

0.479

High

587387

TEBP
Prostaglandin E synthase 3

1

2

High-throughput

0.479

High

587396

Q9BPW0
Serine/threonine-protein phosphatase

1

13

High-throughput

0.479

High

587397

CYBP
Calcyclin-binding protein

1

4

High-throughput

0.479

High

587398

NUDC
Nuclear migration protein nudC

1

6

High-throughput

0.479

High

371077

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.445

High

76509

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

4

High-throughput

0.437

High

587370

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

2

High-throughput

0.437

High

587392

Q6PK50
HSP90AB1 protein

1

20

High-throughput

0.437

High

587393

NUDC3
NudC domain-containing protein 3

1

6

High-throughput

0.437

High

587395

Q96BE0
Heat shock cognate 71 kDa protein

1

20

High-throughput

0.437

High


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Last updated: 11Aug2025