HitPredict

Interactor 1: CSF1 (P07141)
Macrophage colony-stimulating factor 1 (CSF-1) (MCSF) (Proteoglycan macrophage colony-stimulating factor) (PG-M-CSF) [Cleaved into: Processed macrophage colony-stimulating factor 1; Macrophage colony-stimulating factor 1 43 kDa subunit]
Gene: CSF1

Interactor 2: CSF1R (P09581)
Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115)
Gene: CSF1R

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.67 1.00 0.820

The method score is based on:

Property Details
Experiments 19017797, 22153499
Identification Methods isothermal titration calorimetry, x ray scattering, molecular sieving, x-ray crystallography
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains CSF-1~ig
Common GO terms GO:0001780 - neutrophil homeostasis
GO:0002931 - response to ischemia
GO:0005886 - plasma membrane
GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway
GO:0008284 - positive regulation of cell population proliferation
and 12 others

more...
Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 552
Mm

1 977
+ Hs
+ Dr
+ Dr
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024