Protein: DCAF1
DDB1- and CUL4-associated factor 1 (HIV-1 Vpr-binding protein) (VprBP) (Serine/threonine-protein kinase VPRBP) (EC 2.7.11.1) (Vpr-interacting protein)

Gene: DCAF1
Organism: Homo sapiens
Interactions: 209
UniProt ID: Q9Y4B6

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001650 - fibrillar center
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1158011

DDB1
DNA damage-binding protein 1

25

15

Small-scale

0.767

High

1115165

CUL4A
Cullin-4A

15

20

Small-scale

0.759

High

1115494

CUL4B
Cullin-4B

9

20

Small-scale

0.752

High

767383

MERL
Merlin

8

8

Small-scale

0.752

High

1370494

CSN5
COP9 signalosome complex subunit 5

7

10

Small-scale

0.745

High

1272604

CSN6
COP9 signalosome complex subunit 6

6

4

Small-scale

0.733

High

1366149

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

5

14

Small-scale

0.720

High

1235586

IFIX
Pyrin and HIN domain-containing protein 1

5

7

High-throughput

0.718

High

1241068

L2GL2
LLGL scribble cell polarity complex component 2

4

16

High-throughput

0.697

High

1491309

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

4

1

Small-scale

0.692

High

1415920

DDA1
DET1- and DDB1-associated protein 1

4

1

Small-scale

0.686

High

1462391

CSN3
COP9 signalosome complex subunit 3

4

5

Small-scale

0.676

High

898905

RL14
Large ribosomal subunit protein eL14

3

6

High-throughput

0.667

High

1206976

CEP78
Centrosomal protein of 78 kDa

3

4

Small-scale

0.664

High

1406142

CSN8
COP9 signalosome complex subunit 8

4

0

Small-scale

0.664

High

559699

UNG
Uracil-DNA glycosylase

3

1

Small-scale

0.660

High

920395

PLK1
Serine/threonine-protein kinase PLK1

3

6

High-throughput

0.656

High

1458851

CSN7A
COP9 signalosome complex subunit 7a

3

4

Small-scale

0.656

High

718067

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

2

9

Small-scale

0.653

High

1491380

DCAF1
DDB1- and CUL4-associated factor 1

3

16

Small-scale

0.651

High

1094449

CSN1
COP9 signalosome complex subunit 1

3

6

Small-scale

0.650

High

984036

RBX1
E3 ubiquitin-protein ligase RBX1

3

1

Small-scale

0.646

High

244801

ZC3H1
Zinc finger C3H1 domain-containing protein

3

0

High-throughput

0.646

High

349303

LATS1
Serine/threonine-protein kinase LATS1

2

5

Small-scale

0.641

High

1413221

CSN4
COP9 signalosome complex subunit 4

3

1

Small-scale

0.640

High

1398272

TEAN2
Transcription elongation factor A N-terminal and central domain-containing protein 2

3

0

High-throughput

0.634

High

171948

ZN263
Zinc finger protein 263

2

4

High-throughput

0.628

High

612836

RL7
Large ribosomal subunit protein uL30

2

5

High-throughput

0.628

High

960958

RL15
Large ribosomal subunit protein eL15

2

4

High-throughput

0.628

High

1057977

RL18
Large ribosomal subunit protein eL18

2

5

High-throughput

0.628

High

1081808

ZN816
Zinc finger protein 816

2

1

High-throughput

0.628

High

182396

WDR46
WD repeat-containing protein 46

2

19

High-throughput

0.611

High

872932

SOX2
Transcription factor SOX-2

2

20

High-throughput

0.611

High

958740

CSN2
COP9 signalosome complex subunit 2

2

5

Small-scale

0.611

High

1039471

RL6
Large ribosomal subunit protein eL6

2

4

High-throughput

0.611

High

1154969

NEDD8
Ubiquitin-like protein NEDD8

2

4

Small-scale

0.611

High

414908

P53
Cellular tumor antigen p53

2

7

Small-scale

0.602

High

1211368

NOL9
Polynucleotide 5'-hydroxyl-kinase NOL9

2

0

High-throughput

0.602

High

1451483

AKIP
Small ribosomal subunit protein mS38

2

0

High-throughput

0.602

High

1490667

T53G5
TP53-target gene 5 protein

2

0

High-throughput

0.602

High

1327340

ZN276
Zinc finger protein 276

2

5

High-throughput

0.601

High

1461814

ABT1
Activator of basal transcription 1

2

2

High-throughput

0.601

High

1272276

MCM10
Protein MCM10 homolog

2

0

Small-scale

0.598

High

1110216

HDAC1
Histone deacetylase 1

2

10

Small-scale

0.595

High

587399

RAG1
V(D)J recombination-activating protein 1

1

17

Small-scale

0.586

High

162985

TERT
Telomerase reverse transcriptase

2

1

Small-scale

0.584

High

373595

MYC
Myc proto-oncogene protein

2

20

High-throughput

0.584

High

1339524

TET1
Methylcytosine dioxygenase TET1

2

4

Small-scale

0.584

High

1340847

COP1
E3 ubiquitin-protein ligase COP1

2

18

High-throughput

0.584

High

1437210

CSN7B
COP9 signalosome complex subunit 7b

2

4

Small-scale

0.584

High

1448261

SIR7
NAD-dependent protein deacetylase sirtuin-7

2

3

Small-scale

0.584

High

282505

KTNA1
Katanin p60 ATPase-containing subunit A1

1

16

Small-scale

0.578

High

1448726

LATS2
Serine/threonine-protein kinase LATS2

1

7

Small-scale

0.578

High

1051343

KPCZ
Protein kinase C zeta type

2

12

High-throughput

0.571

High

1215536

CE162
Centrosomal protein of 162 kDa

2

20

High-throughput

0.571

High

213285

CP110
Centriolar coiled-coil protein of 110 kDa

1

1

Small-scale

0.561

High

288549

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

13

Small-scale

0.561

High

533981

IRF1
Interferon regulatory factor 1

1

1

Small-scale

0.561

High

1061631

FOXM1
Forkhead box protein M1

1

6

Small-scale

0.561

High

1112353

PWP1
Periodic tryptophan protein 1 homolog

1

17

Small-scale

0.561

High

1236146

TET2
Methylcytosine dioxygenase TET2

1

4

Small-scale

0.561

High

1421349

BC11B
B-cell lymphoma/leukemia 11B

1

1

Small-scale

0.561

High

1453561

PD1L1
Programmed cell death 1 ligand 1

1

1

Small-scale

0.561

High

1462691

EXO1
Exonuclease 1

1

1

Small-scale

0.561

High

1402456

CCNL2
Cyclin-L2

1

5

Small-scale

0.552

High

320805

UBXN7
UBX domain-containing protein 7

1

1

High-throughput

0.536

High

397306

ESR1
Estrogen receptor

1

18

Small-scale

0.536

High

563041

MYH6
Myosin-6

1

3

High-throughput

0.536

High

761941

HSP74
Heat shock 70 kDa protein 4

1

10

High-throughput

0.536

High

767518

RADI
Radixin

1

8

High-throughput

0.536

High

785556

RL4
Large ribosomal subunit protein uL4

1

4

High-throughput

0.536

High

788829

SRP14
Signal recognition particle 14 kDa protein

1

1

High-throughput

0.536

High

824441

RL13A
Large ribosomal subunit protein uL13

1

5

High-throughput

0.536

High

842610

RL35
Large ribosomal subunit protein uL29

1

2

High-throughput

0.536

High

859128

RL27A
Large ribosomal subunit protein uL15

1

7

High-throughput

0.536

High

860429

RS9
Small ribosomal subunit protein uS4

1

5

High-throughput

0.536

High

886625

CTCF
Transcriptional repressor CTCF

1

4

High-throughput

0.536

High

976052

RL7A
Large ribosomal subunit protein eL8

1

11

High-throughput

0.536

High

978802

RL23A
Large ribosomal subunit protein uL23

1

3

High-throughput

0.536

High

979377

RS6
Small ribosomal subunit protein eS6

1

3

High-throughput

0.536

High

982894

RS24
Small ribosomal subunit protein eS24

1

2

High-throughput

0.536

High

1016311

RL19
Large ribosomal subunit protein eL19

1

4

High-throughput

0.536

High

1037704

RL18A
Large ribosomal subunit protein eL20

1

3

High-throughput

0.536

High

1100579

TIF1B
Transcription intermediary factor 1-beta

1

15

High-throughput

0.536

High

1112401

MTMR1
Phosphatidylinositol-3-phosphate phosphatase MTMR1

1

3

High-throughput

0.536

High

1158211

MK14
Mitogen-activated protein kinase 14

1

9

High-throughput

0.536

High

1276072

ZN550
Zinc finger protein 550

1

1

High-throughput

0.536

High

1325104

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

1

High-throughput

0.536

High

1371909

CUL5
Cullin-5

1

20

High-throughput

0.536

High

1395194

ZN462
Zinc finger protein 462

1

2

High-throughput

0.536

High

1415267

KIFC3
Kinesin-like protein KIFC3

1

2

High-throughput

0.536

High

1432734

TXNIP
Thioredoxin-interacting protein

1

6

High-throughput

0.536

High

1433814

SENP3
Sentrin-specific protease 3

1

6

High-throughput

0.536

High

1460850

ZN223
Zinc finger protein 223

1

2

High-throughput

0.536

High

954648

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

2

High-throughput

0.515

High

66822

C2C4B
C2 calcium-dependent domain-containing protein 4B

1

0

High-throughput

0.513

High

486645

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.513

High

503684

TFPT
TCF3 fusion partner

1

0

High-throughput

0.513

High

1310558

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1391982

DCNL1
DCN1-like protein 1

1

0

High-throughput

0.513

High

1454591

MAP10
Microtubule-associated protein 10

1

0

High-throughput

0.513

High

1491381

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

0

High-throughput

0.513

High

1491383

CFA20
Cilia- and flagella-associated protein 20

1

0

High-throughput

0.513

High

957252

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

3

Small-scale

0.501

High

982375

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

3

Small-scale

0.501

High

999000

H31
Histone H3.1

1

11

Small-scale

0.501

High

1008413

PRKDC
DNA-dependent protein kinase catalytic subunit

1

10

Small-scale

0.501

High

1017329

H33
Histone H3.3

1

11

Small-scale

0.501

High

1102301

ATM
Serine-protein kinase ATM

1

10

Small-scale

0.501

High

1109538

ATR
Serine/threonine-protein kinase ATR

1

11

Small-scale

0.501

High

1127782

HLTF
Helicase-like transcription factor

1

8

Small-scale

0.501

High

1162092

H31T
Histone H3.1t

1

11

Small-scale

0.501

High

1411581

PYGO2
Pygopus homolog 2

1

1

Small-scale

0.501

High

483276

CLCA
Clathrin light chain A

1

1

High-throughput

0.489

High

1325665

FGRL1
Fibroblast growth factor receptor-like 1

1

4

High-throughput

0.489

High

1415069

ZN747
Zinc finger protein 747

1

2

High-throughput

0.489

High

1490788

E41L3
Band 4.1-like protein 3

1

4

High-throughput

0.489

High

136156

PLK4
Serine/threonine-protein kinase PLK4

1

8

Small-scale

0.481

High

159931

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

3

High-throughput

0.479

High

188397

HDAC3
Histone deacetylase 3

1

9

Small-scale

0.479

High

207982

TET3
Methylcytosine dioxygenase TET3

1

16

Small-scale

0.479

High

277441

TP4A3
Protein tyrosine phosphatase type IVA 3

1

5

High-throughput

0.479

High

277859

H2AY
Core histone macro-H2A.1

1

9

High-throughput

0.479

High

316209

RECQ4
ATP-dependent DNA helicase Q4

1

20

High-throughput

0.479

High

326119

UBR5
E3 ubiquitin-protein ligase UBR5

1

11

Small-scale

0.479

High

342385

BRD1
Bromodomain-containing protein 1

1

6

High-throughput

0.479

High

412867

NTRK1
High affinity nerve growth factor receptor

1

12

High-throughput

0.479

High

508886

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

9

Small-scale

0.479

High

590118

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

596442

H12
Histone H1.2

1

8

Small-scale

0.479

High

601918

HMGA1
High mobility group protein HMG-I/HMG-Y

1

1

Small-scale

0.479

High

652607

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

15

High-throughput

0.479

High

659325

SP100
Nuclear autoantigen Sp-100

1

20

High-throughput

0.479

High

686547

RL13
Large ribosomal subunit protein eL13

1

4

High-throughput

0.479

High

694092

RL10
Large ribosomal subunit protein uL16

1

4

High-throughput

0.479

High

696959

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

718203

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

9

Small-scale

0.479

High

771019

RORA
Nuclear receptor ROR-alpha

1

13

Small-scale

0.479

High

810481

RL3
Large ribosomal subunit protein uL3

1

6

High-throughput

0.479

High

839850

EPS15
Epidermal growth factor receptor substrate 15

1

4

High-throughput

0.479

High

879659

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

7

Small-scale

0.479

High

957568

UBC12
NEDD8-conjugating enzyme Ubc12

1

4

High-throughput

0.479

High

972171

1433E
14-3-3 protein epsilon

1

5

Small-scale

0.479

High

1005278

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.479

High

1033828

PO5F1
POU domain, class 5, transcription factor 1

1

3

High-throughput

0.479

High

1037455

H11
Histone H1.1

1

8

Small-scale

0.479

High

1045947

TF65
Transcription factor p65

1

5

Small-scale

0.479

High

1052858

DUSP2
Dual specificity protein phosphatase 2

1

2

High-throughput

0.479

High

1112815

CUL1
Cullin-1

1

20

Small-scale

0.479

High

1114738

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1156722

NF2L2
Nuclear factor erythroid 2-related factor 2

1

12

Small-scale

0.479

High

1213487

DCA12
DDB1- and CUL4-associated factor 12

1

1

High-throughput

0.479

High

1226562

DCA15
DDB1- and CUL4-associated factor 15

1

1

High-throughput

0.479

High

1229795

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

1256238

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.479

High

1277022

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1309272

KSR1
Kinase suppressor of Ras 1

1

8

High-throughput

0.479

High

1314286

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

9

High-throughput

0.479

High

1326471

MINK1
Misshapen-like kinase 1

1

4

High-throughput

0.479

High

1339064

NUP43
Nucleoporin Nup43

1

18

High-throughput

0.479

High

1364317

TOPB1
DNA topoisomerase 2-binding protein 1

1

12

Small-scale

0.479

High

1368224

HDAC2
Histone deacetylase 2

1

10

Small-scale

0.479

High

1368696

KAT6A
Histone acetyltransferase KAT6A

1

20

High-throughput

0.479

High

1385151

MOAP1
Modulator of apoptosis 1

1

2

Small-scale

0.479

High

1385477

ZN707
Zinc finger protein 707

1

2

High-throughput

0.479

High

1414922

DUS26
Dual specificity protein phosphatase 26

1

1

High-throughput

0.479

High

1414990

CP250
Centrosome-associated protein CEP250

1

16

High-throughput

0.479

High

1417731

HDAC8
Histone deacetylase 8

1

9

Small-scale

0.479

High

1430232

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

8

Small-scale

0.479

High

1434320

PKHA4
Pleckstrin homology domain-containing family A member 4

1

16

High-throughput

0.479

High

1435492

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

1437945

SP110
Sp110 nuclear body protein

1

19

High-throughput

0.479

High

1459435

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1461990

MYO6
Unconventional myosin-VI

1

7

Small-scale

0.479

High

1462772

SCML2
Sex comb on midleg-like protein 2

1

2

Small-scale

0.479

High

1490713

DJC16
DnaJ homolog subfamily C member 16

1

12

High-throughput

0.470

High

1201264

ESCO2
N-acetyltransferase ESCO2

1

0

Small-scale

0.458

High

1380797

RL36L
Ribosomal protein eL42-like

1

0

High-throughput

0.458

High

1389823

DTBP1
Dysbindin

1

0

High-throughput

0.458

High

1399312

MUS81
Structure-specific endonuclease subunit MUS81

1

0

Small-scale

0.458

High

1399876

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

1403551

PNKP
Bifunctional polynucleotide phosphatase/kinase

1

0

Small-scale

0.458

High

1491382

MOFA1
MORF4 family-associated protein 1

1

0

Small-scale

0.458

High

860067

RL28
Large ribosomal subunit protein eL28

1

3

High-throughput

0.445

High

1159282

ZNF74
Zinc finger protein 74

1

1

High-throughput

0.445

High

1239988

CAVN1
Caveolae-associated protein 1

1

2

High-throughput

0.445

High

1314077

YAF2
YY1-associated factor 2

1

4

High-throughput

0.445

High

1314500

SLX4
Structure-specific endonuclease subunit SLX4

1

12

High-throughput

0.445

High

867552

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.437

High

1250219

LRC31
Leucine-rich repeat-containing protein 31

1

2

High-throughput

0.437

High

1386755

AP2M1
AP-2 complex subunit mu

1

1

High-throughput

0.437

High

1433256

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

5

Small-scale

0.437

High

939482

RAG2
V(D)J recombination-activating protein 2

1

0

Small-scale

0.426

High

1036619

ZNF45
Zinc finger protein 45

1

0

High-throughput

0.426

High

72830

B0UZZ8
WD repeat-containing protein 46

1

18

High-throughput

0.407

High

1290422

LRRT4
Leucine-rich repeat transmembrane neuronal protein 4

1

2

High-throughput

0.407

High

1290512

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

9

High-throughput

0.407

High

399649

VTNC
Vitronectin

2

0

High-throughput

0.328

High

1453234

RM35
Large ribosomal subunit protein bL35m

2

0

High-throughput

0.328

High

1311058

SULF2
Extracellular sulfatase Sulf-2

2

0

High-throughput

0.313

High

1439682

XAGE1
X antigen family member 1

2

0

High-throughput

0.313

High

1211559

F120S
Uncharacterized protein FAM120AOS

1

0

High-throughput

0.279

Low

1359744

HPSE2
Inactive heparanase-2

1

0

High-throughput

0.279

Low

1430677

SMG9
Nonsense-mediated mRNA decay factor SMG9

1

0

High-throughput

0.279

Low

1103812

PLD1
Phospholipase D1

1

0

High-throughput

0.249

Low

63791

KRBA1
Protein KRBA1

1

0

High-throughput

0.232

Low

1185909

TMM95
Sperm-egg fusion protein TMEM95

1

0

High-throughput

0.232

Low

1413260

SYT11
Synaptotagmin-11

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025