HitPredict

Interactor 1: DLG4 (P31016)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Interactor 2: GRASP (Q8R4T5)
General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein) (95 kDa postsynaptic density protein discs-large ZO-1 domain-containing protein) (PSD-95 PDZ domain-containing protein) (Tamalin)
Gene: Tamalin

Species: Rattus norvegicus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.690

Property	Details
Experiments	12586822
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Guanylate_kin~PDZ, PDZ~PDZ
Common GO terms	GO:0005886 - plasma membrane GO:0014069 - postsynaptic density GO:0030165 - PDZ domain binding GO:0045211 - postsynaptic membrane GO:0098978 - glutamatergic synapse
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 724 Rn			1 394
+	Hs
		1006123 DLG4_HUMAN (1-724): 0: 688: 99.86		SHAN2_HUMAN (17-338): 7.61e-42: 159: 16.72
+	Hs
		1006128 DLG4_HUMAN (1-724): 0: 688: 99.86		SHAN1_HUMAN (51-334): 1.56e-37: 146: 18.79
+	Mm
		1223602 DLG4_MOUSE (1-724): 0: 688: 99.45		SHAN2_MOUSE (17-338): 5.1e-36: 142: 17.09
+	Rn
		723905 DLG4_RAT (1-724): 0: 689: 100.00		SHAN1_RAT (51-334): 3.84e-35: 139: 18.69
+	Mm
		92680 DLG4_MOUSE (1-724): 0: 688: 99.45		SHAN1_MOUSE (51-334): 3.84e-35: 139: 18.69
+	Mm
		1223740 DLG4_MOUSE (1-724): 0: 688: 99.45		MAGI3_MOUSE (69-255): 4.62e-29: 121: 22.28
+	Rn
		723902 DLG4_RAT (1-724): 0: 689: 100.00		NHRF3_RAT (46-360): 4.62e-21: 96.7: 15.27
+	Mm
		1193754 DLG4_MOUSE (1-724): 0: 688: 99.45		SHAN3_MOUSE (99-334): 6.45e-15: 78.7: 20.24
+	Mm
		1190114 DLG4_MOUSE (1-724): 0: 688: 99.45		SNX27_MOUSE (106-208): 5.64e-14: 75.3: 26.85
+	Mm
		1000429 DLG4_MOUSE (1-724): 0: 688: 99.45		NHRF1_MOUSE (95-253): 2.45e-10: 63.3: 23.17
+	Mm
		1193811 DLG1_MOUSE (5-724): 0: 599: 68.89		SHAN3_MOUSE (99-334): 6.45e-15: 78.7: 20.24
+	Rn
		1224320 CSKP_RAT (6-203): 2.97e-18: 91.6: 15.08		GRASP_RAT (1-394): 3.7e-107: 322: 100.00
+	Rn
		1224610 DLG2_RAT (225-471): 2.42e-19: 95.1: 21.34		SHAN1_RAT (51-334): 3.84e-35: 139: 18.69
+	Mm
		1000046 EM55_MOUSE (5-325): 3.26e-20: 96.3: 14.85		WHRN_MOUSE (54-241): 4.11e-17: 85.5: 17.37
+	Mm
		1193879 DLG2_MOUSE (225-471): 2.44e-19: 95.1: 21.34		SHAN3_MOUSE (99-334): 6.45e-15: 78.7: 20.24
+	Mm
		1193989 MPP2_MOUSE (2-383): 4.31e-18: 90.5: 15.08		SHAN3_MOUSE (99-334): 6.45e-15: 78.7: 20.24
+	Hs
		1212202 MPP7_HUMAN (31-327): 2.43e-16: 84.7: 12.34		SNX27_HUMAN (106-208): 7.11e-13: 71.8: 25.93
+	Hs
		1325307 PALS1_HUMAN (22-212): 4.52e-14: 77.8: 13.07		MAGI1_HUMAN (80-189): 9.6e-10: 62.5: 27.03