Protein: OPA1
Dynamin-like GTPase OPA1, mitochondrial (EC 3.6.5.5) (Large GTP-binding protein) (LargeG) (Optic atrophy protein 1 homolog) [Cleaved into: Dynamin-like GTPase OPA1, long form (L-OPA1); Dynamin-like GTPase OPA1, short form (S-OPA1)]

Gene: OPA1
Organism: Mus musculus
Interactions: 23
UniProt ID: P58281

Gene Ontology (top 5):
GO:0001843 - neural tube closure
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

945987

OPA1
Dynamin-like GTPase OPA1, mitochondrial

2

16

High-throughput

0.754

High

104483

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

3

High-throughput

0.489

High

945996

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

5

High-throughput

0.489

High

108550

G3X9H5
Huntingtin

1

4

High-throughput

0.479

High

945992

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

3

Small-scale

0.479

High

945994

NEB2
Neurabin-2

1

3

High-throughput

0.479

High

945998

MIC60
MICOS complex subunit Mic60

1

7

High-throughput

0.479

High

945999

SIR3
NAD-dependent protein deacetylase sirtuin-3

1

5

Small-scale

0.479

High

946002

MIC19
MICOS complex subunit Mic19

1

2

High-throughput

0.479

High

946004

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

1

High-throughput

0.479

High

945989

RGS14
Regulator of G-protein signaling 14

1

0

High-throughput

0.458

High

946001

ACO13
Acyl-coenzyme A thioesterase 13

1

0

High-throughput

0.458

High

945988

KCNQ1
Potassium voltage-gated channel subfamily KQT member 1

1

5

High-throughput

0.445

High

945991

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

9

Small-scale

0.445

High

945993

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

3

High-throughput

0.437

High

945997

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

3

High-throughput

0.437

High

946003

Q9D2V3
Progranulin

1

1

High-throughput

0.437

High

450387

CSF1
Macrophage colony-stimulating factor 1

1

2

Small-scale

0.407

High

905793

CAV3
Caveolin-3

1

1

High-throughput

0.407

High

945990

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

6

High-throughput

0.407

High

945995

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.249

Low

946000

HSPB2
Heat shock protein beta-2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025