Protein: MK03
Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (MNK1) (Microtubule-associated protein 2 kinase) (p44-ERK1)

Gene: MK03, Mapk3
Organism: Mus musculus
Interactions: 29
UniProt ID: Q63844

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0001784 - phosphotyrosine residue binding
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004707 - MAP kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1222304

KSR1
Kinase suppressor of Ras 1

3

14

Small-scale

0.827

High

1223464

PEA15
Astrocytic phosphoprotein PEA-15

1

4

Small-scale

0.724

High

1190141

AGAP2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

1

5

High-throughput

0.691

High

1193760

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

9

High-throughput

0.691

High

1224627

SQSTM
Sequestosome-1

1

6

Small-scale

0.691

High

1221490

KLF4
Krueppel-like factor 4

1

8

Small-scale

0.653

High

616120

KS6A3
Ribosomal protein S6 kinase alpha-3

1

20

Small-scale

0.647

High

462122

HS90A
Heat shock protein HSP 90-alpha

1

19

Small-scale

0.618

High

772097

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

10

Small-scale

0.618

High

1224632

DLGP1
Disks large-associated protein 1

2

1

High-throughput

0.611

High

408252

MBP
Myelin basic protein

2

6

Small-scale

0.602

High

591056

KPCE
Protein kinase C epsilon type

1

8

Small-scale

0.575

High

857025

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

2

Small-scale

0.575

High

1224628

NANOG
Homeobox protein NANOG

1

2

Small-scale

0.573

High

1223549

DLG4
Disks large homolog 4

2

9

High-throughput

0.571

High

1224631

SEGN
Secretagogin

1

9

Small-scale

0.553

High

838294

STAT3
Signal transducer and activator of transcription 3

2

5

Small-scale

0.552

High

771480

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

3

High-throughput

0.536

High

147991

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

20

Small-scale

0.503

High

1224630

MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2

1

20

Small-scale

0.503

High

599655

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

17

Small-scale

0.501

High

837021

ELK1
ETS domain-containing protein Elk-1

1

19

Small-scale

0.501

High

104548

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

8

High-throughput

0.479

High

148049

MAP2
Methionine aminopeptidase 2

1

2

Small-scale

0.479

High

205049

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

5

High-throughput

0.479

High

669423

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

3

Small-scale

0.479

High

1029203

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

3

High-throughput

0.479

High

1221670

SC6A4
Sodium-dependent serotonin transporter

1

0

High-throughput

0.458

High

1224629

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

1

High-throughput

0.437

High


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Last updated: 11Aug2025