HitPredict

Interactor 1: DIRA1 (O95057)
GTP-binding protein Di-Ras1 (Distinct subgroup of the Ras family member 1) (Ras-related inhibitor of cell growth) (Rig) (Small GTP-binding tumor suppressor 1)
Gene: DIRAS1

Interactor 2: RAC2 (P15153)
Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2)
Gene: RAC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ras~Ras
Common GO terms	GO:0003924 - GTPase activity GO:0005525 - GTP binding GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 198 Hs			1 192
+	Hs
		925294 RAB35_HUMAN (3-196): 3.21e-86: 254: 29.35		RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19
+	Hs
		545392 RAB35_HUMAN (3-196): 3.21e-86: 254: 29.35		RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00
+	Hs
		892386 RAB35_HUMAN (3-196): 3.21e-86: 254: 29.35		RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01
+	Hs
		894716 RAB8A_HUMAN (4-198): 3.1e-80: 239: 26.34		RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19
+	Hs
		894031 RAB35_HUMAN (3-196): 3.21e-86: 254: 29.35		CDC42_HUMAN (1-192): 4.69e-77: 230: 68.75
+	Dm
		1177642 Q9VH66_DROME (2-178): 7.18e-82: 244: 76.11		Q7JWS8_DROME (2-192): 1.2e-80: 239: 67.54
+	Hs
		564466 RAB8A_HUMAN (4-198): 3.1e-80: 239: 26.34		RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03
+	Hs
		545295 RAB8A_HUMAN (4-198): 3.1e-80: 239: 26.34		RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00
+	Hs
		564470 RAB1A_HUMAN (2-196): 7e-80: 238: 28.71		RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03
+	Hs
		545307 RAB1A_HUMAN (2-196): 7e-80: 238: 28.71		RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00
+	Hs
		900494 RAB35_HUMAN (3-196): 3.21e-86: 254: 29.35		RHOA_HUMAN (5-192): 9.29e-76: 227: 54.26
+	Hs
		892297 RAB8A_HUMAN (4-198): 3.1e-80: 239: 26.34		RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01
+	Hs
		892305 RAB1A_HUMAN (2-196): 7e-80: 238: 28.71		RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01
+	Hs
		894720 RAB8A_HUMAN (4-198): 3.1e-80: 239: 26.34		RHOG_HUMAN (1-192): 1.64e-77: 231: 70.83
+	Hs
		893847 RAB8A_HUMAN (4-198): 3.1e-80: 239: 26.34		CDC42_HUMAN (1-192): 4.69e-77: 230: 68.75
+	Hs
		893872 RAB1A_HUMAN (2-196): 7e-80: 238: 28.71		CDC42_HUMAN (1-192): 4.69e-77: 230: 68.75
+	Hs
		894710 RAB8A_HUMAN (4-198): 3.1e-80: 239: 26.34		RHOA_HUMAN (5-192): 9.29e-76: 227: 54.26
+	Hs
		900355 RAB1A_HUMAN (2-196): 7e-80: 238: 28.71		RHOA_HUMAN (5-192): 9.29e-76: 227: 54.26
+	Hs
		436230 RAB8A_HUMAN (4-198): 3.1e-80: 239: 26.34		RHOC_HUMAN (5-192): 1.83e-73: 221: 54.79
+	Hs
		436244 RAB1A_HUMAN (2-196): 7e-80: 238: 28.71		RHOC_HUMAN (5-192): 1.83e-73: 221: 54.79