Protein: XPF
DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein)

Gene: XPF, ERCC4
Organism: Homo sapiens
Interactions: 76
UniProt ID: Q92889

Gene Ontology (top 5):
GO:0000014 - single-stranded DNA endodeoxyribonuclease activity
GO:0000109 - nucleotide-excision repair complex
GO:0000110 - nucleotide-excision repair factor 1 complex
GO:0000723 - telomere maintenance
GO:0000712 - resolution of meiotic recombination intermediates

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

434589

ERCC1
DNA excision repair protein ERCC-1

28

4

Small-scale

0.993

High

1272207

XPF
DNA repair endonuclease XPF

3

2

Small-scale

0.870

High

1272210

MUS81
Crossover junction endonuclease MUS81

2

1

High-throughput

0.811

High

1222500

SLX4
Structure-specific endonuclease subunit SLX4

18

3

Small-scale

0.766

High

612490

XPA
DNA repair protein complementing XP-A cells

4

2

Small-scale

0.696

High

861871

PLK1
Serine/threonine-protein kinase PLK1

5

0

High-throughput

0.693

High

1272213

SLX1
Structure-specific endonuclease subunit SLX1

3

0

Small-scale

0.647

High

1272208

EME1
Crossover junction endonuclease EME1

1

2

Small-scale

0.618

High

264077

TACC1
Transforming acidic coiled-coil-containing protein 1

2

1

High-throughput

0.606

High

230408

ZC3H1
Zinc finger C3H1 domain-containing protein

2

0

High-throughput

0.602

High

1246548

IKBD
NF-kappa-B inhibitor delta

2

0

High-throughput

0.602

High

651858

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

2

Small-scale

0.594

High

1272215

FACD2
Fanconi anemia group D2 protein

2

1

Small-scale

0.584

High

902702

SUMO2
Small ubiquitin-related modifier 2

2

0

Small-scale

0.577

High

795506

RAD52
DNA repair protein RAD52 homolog

1

0

Small-scale

0.561

High

855703

KIF11
Kinesin-like protein KIF11

1

0

Small-scale

0.537

High

841287

CDK7
Cyclin-dependent kinase 7

1

1

High-throughput

0.536

High

1029294

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

1

High-throughput

0.536

High

1231839

PIAS4
E3 SUMO-protein ligase PIAS4

1

2

High-throughput

0.536

High

1272222

CABIN
Calcineurin-binding protein cabin-1

1

1

High-throughput

0.536

High

360657

SPTA1
Spectrin alpha chain, erythrocytic 1

2

2

Small-scale

0.533

High

1045475

SPTN1
Spectrin alpha chain, non-erythrocytic 1

2

2

Small-scale

0.533

High

125912

CDC7
Cell division cycle 7-related protein kinase

1

0

High-throughput

0.513

High

269536

SKAP2
Src kinase-associated phosphoprotein 2

1

0

High-throughput

0.513

High

338797

EGFR
Epidermal growth factor receptor

1

0

Small-scale

0.513

High

853674

IMA5
Importin subunit alpha-5

1

0

High-throughput

0.513

High

943743

PRAME
Melanoma antigen preferentially expressed in tumors

1

0

High-throughput

0.513

High

1039010

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

0

High-throughput

0.513

High

1057991

RRP5
Protein RRP5 homolog

1

0

High-throughput

0.513

High

1069457

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.513

High

1101477

ZN423
Zinc finger protein 423

1

0

High-throughput

0.513

High

1232551

STAG2
Cohesin subunit SA-2

1

0

High-throughput

0.513

High

1272209

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

1

0

High-throughput

0.513

High

1272212

NP1L3
Nucleosome assembly protein 1-like 3

1

0

High-throughput

0.513

High

1272216

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.513

High

1272220

ANGE1
Protein angel homolog 1

1

0

High-throughput

0.513

High

282704

RNF8
E3 ubiquitin-protein ligase RNF8

1

3

Small-scale

0.500

High

499982

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.493

High

301952

TRI37
E3 ubiquitin-protein ligase TRIM37

1

2

High-throughput

0.489

High

174424

FANCG
Fanconi anemia group G protein

1

2

Small-scale

0.481

High

553344

RFA2
Replication protein A 32 kDa subunit

1

1

Small-scale

0.481

High

176624

FANCA
Fanconi anemia group A protein

1

1

Small-scale

0.479

High

228256

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

749738

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.479

High

794291

MSH2
DNA mismatch repair protein Msh2

1

2

Small-scale

0.479

High

1019054

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

1056912

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

High-throughput

0.479

High

266401

TAD2A
Transcriptional adapter 2-alpha

1

0

High-throughput

0.458

High

455724

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

624981

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.458

High

668877

PML
Protein PML

1

0

High-throughput

0.458

High

697762

TF2H1
General transcription factor IIH subunit 1

1

0

Small-scale

0.458

High

782614

HNF4A
Hepatocyte nuclear factor 4-alpha

1

0

High-throughput

0.458

High

902985

DCAF7
DDB1- and CUL4-associated factor 7

1

0

Small-scale

0.458

High

918575

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

941255

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

976493

ERCC6
DNA excision repair protein ERCC-6

1

0

Small-scale

0.458

High

1161816

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

1174152

UBP45
Ubiquitin carboxyl-terminal hydrolase 45

1

0

Small-scale

0.458

High

1200832

SHLD2
Shieldin complex subunit 2

1

0

High-throughput

0.458

High

1236419

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

1272211

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

0

Small-scale

0.458

High

1272214

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1272217

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1272218

RTEL1
Regulator of telomere elongation helicase 1

1

0

Small-scale

0.458

High

1272219

ZMYM2
Zinc finger MYM-type protein 2

1

0

High-throughput

0.458

High

882478

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.437

High

1171082

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1079561

NEDD8
NEDD8

1

0

Small-scale

0.426

High

1131987

CJ055
Uncharacterized protein C10orf55

3

0

High-throughput

0.342

High

409794

GLPB
Glycophorin-B

2

0

High-throughput

0.328

High

1139546

SLX4I
Protein SLX4IP

2

0

Small-scale

0.318

High

1103408

AP5B1
AP-5 complex subunit beta-1

1

0

High-throughput

0.279

Low

1272221

IFT52
Intraflagellar transport protein 52 homolog

1

0

High-throughput

0.279

Low

385288

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024